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Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response.
Adv Virus Res. 2016; 96:219-243.AV

Abstract

Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are the most severe coronavirus (CoV)-associated diseases in humans. The causative agents, SARS-CoV and MERS-CoV, are of zoonotic origin but may be transmitted to humans, causing severe and often fatal respiratory disease in their new host. The two coronaviruses are thought to encode an unusually large number of factors that allow them to thrive and replicate in the presence of efficient host defense mechanisms, especially the antiviral interferon system. Here, we review the recent progress in our understanding of the strategies that highly pathogenic coronaviruses employ to escape, dampen, or block the antiviral interferon response in human cells.

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Authors+Show Affiliations

Kindler E
University of Bern, Bern, Switzerland; Institute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
Thiel V
University of Bern, Bern, Switzerland; Institute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
Weber F
Institute of Virology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, Giessen, Germany. Electronic address: friedemann.weber@vetmed.uni-giessen.de.

MeSH

Coronavirus InfectionsGene Expression RegulationHumansImmune EvasionImmunity, InnateInterferon-alphaInterferon-betaInterferon-gammaJanus Kinase 1Middle East Respiratory Syndrome CoronavirusRNA, Double-StrandedRNA, ViralSevere acute respiratory syndrome-related coronavirusSTAT Transcription FactorsSevere Acute Respiratory SyndromeSignal TransductionViral Proteins

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27712625

Citation

Kindler, E, et al. "Interaction of SARS and MERS Coronaviruses With the Antiviral Interferon Response." Advances in Virus Research, vol. 96, 2016, pp. 219-243.
Kindler E, Thiel V, Weber F. Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response. Adv Virus Res. 2016;96:219-243.
Kindler, E., Thiel, V., & Weber, F. (2016). Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response. Advances in Virus Research, 96, 219-243. https://doi.org/10.1016/bs.aivir.2016.08.006
Kindler E, Thiel V, Weber F. Interaction of SARS and MERS Coronaviruses With the Antiviral Interferon Response. Adv Virus Res. 2016;96:219-243. PubMed PMID: 27712625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response. AU - Kindler,E, AU - Thiel,V, AU - Weber,F, Y1 - 2016/09/09/ PY - 2016/10/8/entrez PY - 2016/10/8/pubmed PY - 2017/1/12/medline KW - Interferon KW - MDA5 KW - MERS-CoV KW - PKR KW - RIG-I-like receptors KW - SARS-CoV KW - Viral countermeasures SP - 219 EP - 243 JF - Advances in virus research JO - Adv Virus Res VL - 96 N2 - Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are the most severe coronavirus (CoV)-associated diseases in humans. The causative agents, SARS-CoV and MERS-CoV, are of zoonotic origin but may be transmitted to humans, causing severe and often fatal respiratory disease in their new host. The two coronaviruses are thought to encode an unusually large number of factors that allow them to thrive and replicate in the presence of efficient host defense mechanisms, especially the antiviral interferon system. Here, we review the recent progress in our understanding of the strategies that highly pathogenic coronaviruses employ to escape, dampen, or block the antiviral interferon response in human cells. SN - 1557-8399 UR - https://www.unboundmedicine.com/medline/citation/27712625/Interaction_of_SARS_and_MERS_Coronaviruses_with_the_Antiviral_Interferon_Response_ DB - PRIME DP - Unbound Medicine ER -