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Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis.
Immunol Allergy Clin North Am. 2016 11; 36(4):669-680.IA

Abstract

Aspirin-Exacerbated Respiratory Disease (AERD) and Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) are both characterized by the presence of chronic sinonasal inflammation and nasal polyps. Unlike in CRSwNP, AERD patients develop respiratory reactions following ingestion of COX-1 inhibitors. AERD patients also, on average, have worse upper respiratory disease with increased sinonasal symptoms, mucosal inflammation and requirements for revision sinus surgery when compared to CRSwNP patients. While no single genetic factor has been identified in either CRSwNP or AERD to date, differences in the metabolism of arachidonic acid as well as innate immune cell activation may uniquely contribute to AERD pathogenesis.

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Authors+Show Affiliations

Stevens WW
Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, 240 E. Huron St, Chicago, IL 60611, USA.
Schleimer RP
Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, 240 E. Huron St, Chicago, IL 60611, USA; Department of Otolaryngology, Northwestern University Feinberg School of Medicine, 675 N St. Clair St Suite 15-200, Chicago, IL 60611, USA. Electronic address: rpschleimer@northwestern.edu.

MeSH

Anti-Inflammatory Agents, Non-SteroidalAspirinChronic DiseaseHumansRespiratory Tract DiseasesRhinitisSinusitis

Pub Type(s)

Journal Article
Review
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

27712762

Citation

Stevens, Whitney W., and Robert P. Schleimer. "Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis." Immunology and Allergy Clinics of North America, vol. 36, no. 4, 2016, pp. 669-680.
Stevens WW, Schleimer RP. Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis. Immunol Allergy Clin North Am. 2016;36(4):669-680.
Stevens, W. W., & Schleimer, R. P. (2016). Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis. Immunology and Allergy Clinics of North America, 36(4), 669-680. https://doi.org/10.1016/j.iac.2016.06.004
Stevens WW, Schleimer RP. Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis. Immunol Allergy Clin North Am. 2016;36(4):669-680. PubMed PMID: 27712762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis. AU - Stevens,Whitney W, AU - Schleimer,Robert P, Y1 - 2016/09/13/ PY - 2016/10/8/entrez PY - 2016/10/8/pubmed PY - 2017/12/23/medline KW - AERD KW - Aspirin-exacerbated respiratory disease KW - CRSwNP KW - Chronic rhinosinusitis KW - Chronic rhinosinusitis with nasal polyps KW - Samter disease KW - Samter triad SP - 669 EP - 680 JF - Immunology and allergy clinics of North America JO - Immunol Allergy Clin North Am VL - 36 IS - 4 N2 - Aspirin-Exacerbated Respiratory Disease (AERD) and Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) are both characterized by the presence of chronic sinonasal inflammation and nasal polyps. Unlike in CRSwNP, AERD patients develop respiratory reactions following ingestion of COX-1 inhibitors. AERD patients also, on average, have worse upper respiratory disease with increased sinonasal symptoms, mucosal inflammation and requirements for revision sinus surgery when compared to CRSwNP patients. While no single genetic factor has been identified in either CRSwNP or AERD to date, differences in the metabolism of arachidonic acid as well as innate immune cell activation may uniquely contribute to AERD pathogenesis. SN - 1557-8607 UR - https://www.unboundmedicine.com/medline/citation/27712762/Aspirin_Exacerbated_Respiratory_Disease_as_an_Endotype_of_Chronic_Rhinosinusitis_ DB - PRIME DP - Unbound Medicine ER -