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Changes in plasma ghrelin and leptin levels in patients with peptic ulcer and gastritis following eradication of Helicobacter pylori infection.
BMC Gastroenterol. 2016 Oct 04; 16(1):119.BG

Abstract

BACKGROUND

Helicobacter pylori (H. pylori) infection and eradication therapy have been known to influence gastric ghrelin and leptin secretion, which may lead to weight gain. However, the exact relationship between plasma ghrelin/leptin levels and H. pylori infection has remained controversial. The aim of this study was to investigate plasma ghrelin and leptin levels in H. pylori-positive and -negative patients, to compare the two levels of the hormones before and after H. pylori eradication, and to examine the correlation between body mass index (BMI) and active ghrelin or leptin levels, as well as that between atrophic pattern and active ghrelin or leptin levels.

METHODS

Seventy-two H. pylori-positive patients who underwent upper gastrointestinal endoscopy, 46 diagnosed as having peptic ulcer and 26 as atrophic gastritis, were enrolled. Control samples were obtained from 15 healthy H. pylori-negative volunteers. The extent of atrophic change of the gastric mucosa was assessed endoscopically. Body weight was measured and blood was collected before and 12 weeks after H. pylori eradication therapy. Blood samples were taken between 8 and 10 AM after an overnight fast.

RESULTS

Plasma ghrelin levels were significantly lower in H. pylori-positive patients than in H. pylori-negative patients. In particular, plasma active ghrelin levels were significantly lower in patients with gastritis compared with patients with peptic ulcer. Plasma ghrelin levels decreased after H. pylori eradication in both peptic ulcer and gastritis patients, while plasma leptin levels increased only in peptic ulcer patients. Plasma leptin levels and BMI were positively correlated, and active ghrelin levels and atrophic pattern were weakly negatively correlated in peptic ulcer patients.

CONCLUSION

H. pylori infection and eradication therapy may affect circulating ghrelin/leptin levels. This finding suggests a relationship between gastric mucosal injury induced by H. pylori infection and changes in plasma ghrelin and leptin levels.

Authors+Show Affiliations

Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.Department of Molecular and Laboratory Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan. kazushi@clin.medic.mie-u.ac.jp. Department of Gastroenterology and Hepatology, Mie University School of Medicine, Tsu, Japan. kazushi@clin.medic.mie-u.ac.jp.Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.Department of Molecular and Laboratory Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan. Department of Gastroenterology and Hepatology, Mie University School of Medicine, Tsu, Japan.Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.Department of Cardiology and Nephrology, Mie University School of Medicine, Tsu, Japan.Department of Gastroenterology and Hepatology, Mie University School of Medicine, Tsu, Japan.Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27716077

Citation

Kasai, Chika, et al. "Changes in Plasma Ghrelin and Leptin Levels in Patients With Peptic Ulcer and Gastritis Following Eradication of Helicobacter Pylori Infection." BMC Gastroenterology, vol. 16, no. 1, 2016, p. 119.
Kasai C, Sugimoto K, Moritani I, et al. Changes in plasma ghrelin and leptin levels in patients with peptic ulcer and gastritis following eradication of Helicobacter pylori infection. BMC Gastroenterol. 2016;16(1):119.
Kasai, C., Sugimoto, K., Moritani, I., Tanaka, J., Oya, Y., Inoue, H., Tameda, M., Shiraki, K., Ito, M., Takei, Y., & Takase, K. (2016). Changes in plasma ghrelin and leptin levels in patients with peptic ulcer and gastritis following eradication of Helicobacter pylori infection. BMC Gastroenterology, 16(1), 119.
Kasai C, et al. Changes in Plasma Ghrelin and Leptin Levels in Patients With Peptic Ulcer and Gastritis Following Eradication of Helicobacter Pylori Infection. BMC Gastroenterol. 2016 Oct 4;16(1):119. PubMed PMID: 27716077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in plasma ghrelin and leptin levels in patients with peptic ulcer and gastritis following eradication of Helicobacter pylori infection. AU - Kasai,Chika, AU - Sugimoto,Kazushi, AU - Moritani,Isao, AU - Tanaka,Junichiro, AU - Oya,Yumi, AU - Inoue,Hidekazu, AU - Tameda,Masahiko, AU - Shiraki,Katsuya, AU - Ito,Masaaki, AU - Takei,Yoshiyuki, AU - Takase,Kojiro, Y1 - 2016/10/04/ PY - 2016/03/05/received PY - 2016/09/17/accepted PY - 2016/10/8/entrez PY - 2016/10/8/pubmed PY - 2017/2/10/medline KW - Eradication KW - Helicobacter pylori KW - Plasma Ghrelin and Leptin SP - 119 EP - 119 JF - BMC gastroenterology JO - BMC Gastroenterol VL - 16 IS - 1 N2 - BACKGROUND: Helicobacter pylori (H. pylori) infection and eradication therapy have been known to influence gastric ghrelin and leptin secretion, which may lead to weight gain. However, the exact relationship between plasma ghrelin/leptin levels and H. pylori infection has remained controversial. The aim of this study was to investigate plasma ghrelin and leptin levels in H. pylori-positive and -negative patients, to compare the two levels of the hormones before and after H. pylori eradication, and to examine the correlation between body mass index (BMI) and active ghrelin or leptin levels, as well as that between atrophic pattern and active ghrelin or leptin levels. METHODS: Seventy-two H. pylori-positive patients who underwent upper gastrointestinal endoscopy, 46 diagnosed as having peptic ulcer and 26 as atrophic gastritis, were enrolled. Control samples were obtained from 15 healthy H. pylori-negative volunteers. The extent of atrophic change of the gastric mucosa was assessed endoscopically. Body weight was measured and blood was collected before and 12 weeks after H. pylori eradication therapy. Blood samples were taken between 8 and 10 AM after an overnight fast. RESULTS: Plasma ghrelin levels were significantly lower in H. pylori-positive patients than in H. pylori-negative patients. In particular, plasma active ghrelin levels were significantly lower in patients with gastritis compared with patients with peptic ulcer. Plasma ghrelin levels decreased after H. pylori eradication in both peptic ulcer and gastritis patients, while plasma leptin levels increased only in peptic ulcer patients. Plasma leptin levels and BMI were positively correlated, and active ghrelin levels and atrophic pattern were weakly negatively correlated in peptic ulcer patients. CONCLUSION: H. pylori infection and eradication therapy may affect circulating ghrelin/leptin levels. This finding suggests a relationship between gastric mucosal injury induced by H. pylori infection and changes in plasma ghrelin and leptin levels. SN - 1471-230X UR - https://www.unboundmedicine.com/medline/citation/27716077/Changes_in_plasma_ghrelin_and_leptin_levels_in_patients_with_peptic_ulcer_and_gastritis_following_eradication_of_Helicobacter_pylori_infection_ L2 - https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-016-0532-2 DB - PRIME DP - Unbound Medicine ER -