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Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial.
Nutr J. 2016 10 06; 15(1):85.NJ

Abstract

BACKGROUND

It has been reported that higher levels of oxidative stress and inflammation play a key role in the progression of hepatocellular carcinoma (HCC) after surgery. Coenzyme Q10 is an endogenous lipid-soluble antioxidant. To date, no intervention study has investigated coenzyme Q10 supplementation in HCC patients after surgery. The purpose of this study was to investigate oxidative stress, antioxidant enzymes activity, and inflammation levels in HCC patients after surgery following administration of coenzyme Q10 (300 mg/day).

METHODS

This study was designed as a single-blinded, randomized, parallel, placebo-controlled study. Patients who were diagnosed with primary HCC (n = 41) and were randomly assign to a placebo (n = 20) or coenzyme Q10 (300 mg/day, n = 21) group after surgery. The intervention lasted for 12 weeks. Plasma coenzyme Q10, vitamin E, oxidative stress antioxidant enzymes activity and inflammatory markers levels were measured.

RESULTS

The oxidative stress (p = 0.04) and inflammatory markers (hs-CRP and IL-6, p < 0.01) levels were significantly decreased, and the antioxidant enzymes activity was significantly increased (p < 0.01) after 12 weeks of coenzyme Q10 supplementation. In addition, the coenzyme Q10 level was significantly negatively correlated with the oxidative stress (p = 0.01), and positively correlated with antioxidant enzymes activity (SOD, p = 0.01; CAT, p < 0.05; GPx, p = 0.04) and vitamin E level (p = 0.01) after supplementation.

CONCLUSION

In conclusion, we demonstrated that a dose of 300 mg/d of coenzyme Q10 supplementation significantly increased the antioxidant capacity and reduced the oxidative stress and inflammation levels in HCC patients after surgery.

TRIAL REGISTRATION

Clinical Trials.gov Identifier: NCT01964001.

Authors+Show Affiliations

Graduate Program in Nutrition, Chung Shan Medical University, Taichung, 40201, Taiwan. Division of General Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, 40705, Taiwan.Department of Nutrition, Chung Shan Medical University, Taichung, 40201, Taiwan.Graduate Program in Nutrition, Chung Shan Medical University, Taichung, 40201, Taiwan. Division of General Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, 40705, Taiwan.Division of General Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, 40705, Taiwan.Department of Nutrition, Chung Shan Medical University, Taichung, 40201, Taiwan. apt810@csmu.edu.tw. Department of Nutrition, Chung Shan Medical University Hospital, Taichung, 40201, Taiwan. apt810@csmu.edu.tw.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27716246

Citation

Liu, Hsiao-Tien, et al. "Effects of Coenzyme Q10 Supplementation On Antioxidant Capacity and Inflammation in Hepatocellular Carcinoma Patients After Surgery: a Randomized, Placebo-controlled Trial." Nutrition Journal, vol. 15, no. 1, 2016, p. 85.
Liu HT, Huang YC, Cheng SB, et al. Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial. Nutr J. 2016;15(1):85.
Liu, H. T., Huang, Y. C., Cheng, S. B., Huang, Y. T., & Lin, P. T. (2016). Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial. Nutrition Journal, 15(1), 85.
Liu HT, et al. Effects of Coenzyme Q10 Supplementation On Antioxidant Capacity and Inflammation in Hepatocellular Carcinoma Patients After Surgery: a Randomized, Placebo-controlled Trial. Nutr J. 2016 10 6;15(1):85. PubMed PMID: 27716246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial. AU - Liu,Hsiao-Tien, AU - Huang,Yi-Chia, AU - Cheng,Shao-Bin, AU - Huang,Yin-Tzu, AU - Lin,Ping-Ting, Y1 - 2016/10/06/ PY - 2016/08/15/received PY - 2016/10/03/accepted PY - 2016/10/8/entrez PY - 2016/10/8/pubmed PY - 2017/10/31/medline KW - Antioxidation KW - Coenzyme Q10 supplementation KW - Hepatocellular carcinoma KW - Inflammation KW - Oxidative stress KW - Surgery SP - 85 EP - 85 JF - Nutrition journal JO - Nutr J VL - 15 IS - 1 N2 - BACKGROUND: It has been reported that higher levels of oxidative stress and inflammation play a key role in the progression of hepatocellular carcinoma (HCC) after surgery. Coenzyme Q10 is an endogenous lipid-soluble antioxidant. To date, no intervention study has investigated coenzyme Q10 supplementation in HCC patients after surgery. The purpose of this study was to investigate oxidative stress, antioxidant enzymes activity, and inflammation levels in HCC patients after surgery following administration of coenzyme Q10 (300 mg/day). METHODS: This study was designed as a single-blinded, randomized, parallel, placebo-controlled study. Patients who were diagnosed with primary HCC (n = 41) and were randomly assign to a placebo (n = 20) or coenzyme Q10 (300 mg/day, n = 21) group after surgery. The intervention lasted for 12 weeks. Plasma coenzyme Q10, vitamin E, oxidative stress antioxidant enzymes activity and inflammatory markers levels were measured. RESULTS: The oxidative stress (p = 0.04) and inflammatory markers (hs-CRP and IL-6, p < 0.01) levels were significantly decreased, and the antioxidant enzymes activity was significantly increased (p < 0.01) after 12 weeks of coenzyme Q10 supplementation. In addition, the coenzyme Q10 level was significantly negatively correlated with the oxidative stress (p = 0.01), and positively correlated with antioxidant enzymes activity (SOD, p = 0.01; CAT, p < 0.05; GPx, p = 0.04) and vitamin E level (p = 0.01) after supplementation. CONCLUSION: In conclusion, we demonstrated that a dose of 300 mg/d of coenzyme Q10 supplementation significantly increased the antioxidant capacity and reduced the oxidative stress and inflammation levels in HCC patients after surgery. TRIAL REGISTRATION: Clinical Trials.gov Identifier: NCT01964001. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/27716246/Effects_of_coenzyme_Q10_supplementation_on_antioxidant_capacity_and_inflammation_in_hepatocellular_carcinoma_patients_after_surgery:_a_randomized_placebo_controlled_trial_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/s12937-016-0205-6 DB - PRIME DP - Unbound Medicine ER -