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Associations of Serum Levels of Sex Hormones in Follicular and Luteal Phases of the Menstrual Cycle with Breast Tissue Characteristics in Young Women.
PLoS One. 2016; 11(10):e0163865.Plos

Abstract

BACKGROUND

In previous work in young women aged 15-30 years we measured breast water and fat using MR and obtained blood for hormone assays on the same day in the follicular phase of the menstrual cycle. Only serum growth hormone levels and sex hormone binding globulin (SHBG) were significantly associated with percent breast water after adjustment for covariates. The sex hormones estradiol, progesterone and testosterone were not associated with percent water in the breast in the follicular phase of the menstrual cycle. In the present study we have examined the association of percent breast water with serum levels of sex hormones in both follicular and luteal phase of the menstrual cycle.

METHODS

In 315 healthy white Caucasian young women aged 15-30 with regular menstrual cycles who had not used oral contraceptives or other hormones in the previous 6 months, we used MR to determine percent breast water, and obtained blood samples for hormone assays within 10 days of the onset of the most recent menstrual cycle (follicular phase) of the cycle on the same day as the MR scan, and a second blood sample on days 19-24 of the cycle. Serum progesterone levels of > = 5 mmol/L in days 19-24 were used to define the 225 subjects with ovulatory menstrual cycles, whose data are the subject of the analyses shown here.

RESULTS

SHBG was positively associated with percent water in both follicular and luteal phases of the menstrual cycle. Total and free estradiol and total and free testosterone were not associated with percent water in the follicular phase, but in young women with ovulatory cycles, were all negatively associated with percent water in the luteal phase.

CONCLUSIONS

Our results from young women aged 15-30 years add to the evidence that the extent of fibroglandular tissue in the breast that is reflected in both mammographic density and breast water is associated positively with higher serum levels of SHBG, but not with higher levels of sex hormones.

Authors+Show Affiliations

Campbell Family Institute for Breast Cancer Research, Toronto, ON, Canada.Campbell Family Institute for Breast Cancer Research, Toronto, ON, Canada.Family Practice Health Centre, Women's College Hospital, Toronto, ON, Canada.Campbell Family Institute for Breast Cancer Research, Toronto, ON, Canada.Sunnybrook Health Sciences Centre, Toronto, ON, Canada.Sunnybrook Health Sciences Centre, Toronto, ON, Canada.Campbell Family Institute for Breast Cancer Research, Toronto, ON, Canada.Princess Margaret Cancer Centre, and Imaging Research, Toronto, ON, Canada.Campbell Family Institute for Breast Cancer Research, Toronto, ON, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27716810

Citation

Linton, Linda, et al. "Associations of Serum Levels of Sex Hormones in Follicular and Luteal Phases of the Menstrual Cycle With Breast Tissue Characteristics in Young Women." PloS One, vol. 11, no. 10, 2016, pp. e0163865.
Linton L, Taylor M, Dunn S, et al. Associations of Serum Levels of Sex Hormones in Follicular and Luteal Phases of the Menstrual Cycle with Breast Tissue Characteristics in Young Women. PLoS ONE. 2016;11(10):e0163865.
Linton, L., Taylor, M., Dunn, S., Martin, L., Chavez, S., Stanitz, G., Huszti, E., Minkin, S., & Boyd, N. (2016). Associations of Serum Levels of Sex Hormones in Follicular and Luteal Phases of the Menstrual Cycle with Breast Tissue Characteristics in Young Women. PloS One, 11(10), e0163865. https://doi.org/10.1371/journal.pone.0163865
Linton L, et al. Associations of Serum Levels of Sex Hormones in Follicular and Luteal Phases of the Menstrual Cycle With Breast Tissue Characteristics in Young Women. PLoS ONE. 2016;11(10):e0163865. PubMed PMID: 27716810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of Serum Levels of Sex Hormones in Follicular and Luteal Phases of the Menstrual Cycle with Breast Tissue Characteristics in Young Women. AU - Linton,Linda, AU - Taylor,Monica, AU - Dunn,Sheila, AU - Martin,Lisa, AU - Chavez,Sonia, AU - Stanitz,Greg, AU - Huszti,Ella, AU - Minkin,Salomon, AU - Boyd,Norman, Y1 - 2016/10/07/ PY - 2016/03/31/received PY - 2016/09/15/accepted PY - 2016/10/8/entrez PY - 2016/10/8/pubmed PY - 2017/6/21/medline SP - e0163865 EP - e0163865 JF - PloS one JO - PLoS ONE VL - 11 IS - 10 N2 - BACKGROUND: In previous work in young women aged 15-30 years we measured breast water and fat using MR and obtained blood for hormone assays on the same day in the follicular phase of the menstrual cycle. Only serum growth hormone levels and sex hormone binding globulin (SHBG) were significantly associated with percent breast water after adjustment for covariates. The sex hormones estradiol, progesterone and testosterone were not associated with percent water in the breast in the follicular phase of the menstrual cycle. In the present study we have examined the association of percent breast water with serum levels of sex hormones in both follicular and luteal phase of the menstrual cycle. METHODS: In 315 healthy white Caucasian young women aged 15-30 with regular menstrual cycles who had not used oral contraceptives or other hormones in the previous 6 months, we used MR to determine percent breast water, and obtained blood samples for hormone assays within 10 days of the onset of the most recent menstrual cycle (follicular phase) of the cycle on the same day as the MR scan, and a second blood sample on days 19-24 of the cycle. Serum progesterone levels of > = 5 mmol/L in days 19-24 were used to define the 225 subjects with ovulatory menstrual cycles, whose data are the subject of the analyses shown here. RESULTS: SHBG was positively associated with percent water in both follicular and luteal phases of the menstrual cycle. Total and free estradiol and total and free testosterone were not associated with percent water in the follicular phase, but in young women with ovulatory cycles, were all negatively associated with percent water in the luteal phase. CONCLUSIONS: Our results from young women aged 15-30 years add to the evidence that the extent of fibroglandular tissue in the breast that is reflected in both mammographic density and breast water is associated positively with higher serum levels of SHBG, but not with higher levels of sex hormones. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27716810/Associations_of_Serum_Levels_of_Sex_Hormones_in_Follicular_and_Luteal_Phases_of_the_Menstrual_Cycle_with_Breast_Tissue_Characteristics_in_Young_Women_ L2 - http://dx.plos.org/10.1371/journal.pone.0163865 DB - PRIME DP - Unbound Medicine ER -