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Religious and spiritual importance moderate relation between default mode network connectivity and familial risk for depression.
Neurosci Lett 2016; 634:94-97NL

Abstract

Individuals at high risk for depression have increased default mode network (DMN) connectivity, as well as reduced inverse connectivity between the DMN and the central executive network (CEN) [8]. Other studies have indicated that the belief in the importance of religion/spirituality (R/S) is protective against depression in high risk individuals [5]. Given these findings, we hypothesized that R/S importance would moderate DMN connectivity, potentially reducing DMN connectivity or increasing DMN-CEN inverse connectivity in individuals at high risk for depression. Using resting-state functional connectivity MRI (rs-fcMRI) in a sample of 104 individuals (aged 11-60) at high and low risk for familial depression, we previously reported increased DMN connectivity and reduced DMN-CEN inverse connectivity in high risk individuals. Here, we found that this effect was moderated by self-report measures of R/S importance. Greater R/S importance in the high risk group was associated with decreased DMN connectivity. These results may represent a protective neural adaptation in the DMN of individuals at high risk for depression, and may have implications for other meditation-based therapies for depression.

Authors+Show Affiliations

Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA. Electronic address: consvob@nyspi.columbia.edu.Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27717831

Citation

Svob, Connie, et al. "Religious and Spiritual Importance Moderate Relation Between Default Mode Network Connectivity and Familial Risk for Depression." Neuroscience Letters, vol. 634, 2016, pp. 94-97.
Svob C, Wang Z, Weissman MM, et al. Religious and spiritual importance moderate relation between default mode network connectivity and familial risk for depression. Neurosci Lett. 2016;634:94-97.
Svob, C., Wang, Z., Weissman, M. M., Wickramaratne, P., & Posner, J. (2016). Religious and spiritual importance moderate relation between default mode network connectivity and familial risk for depression. Neuroscience Letters, 634, pp. 94-97. doi:10.1016/j.neulet.2016.10.009.
Svob C, et al. Religious and Spiritual Importance Moderate Relation Between Default Mode Network Connectivity and Familial Risk for Depression. Neurosci Lett. 2016 Nov 10;634:94-97. PubMed PMID: 27717831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Religious and spiritual importance moderate relation between default mode network connectivity and familial risk for depression. AU - Svob,Connie, AU - Wang,Zhishun, AU - Weissman,Myrna M, AU - Wickramaratne,Priya, AU - Posner,Jonathan, Y1 - 2016/10/04/ PY - 2016/04/22/received PY - 2016/09/29/revised PY - 2016/10/02/accepted PY - 2016/11/7/entrez PY - 2016/10/26/pubmed PY - 2017/8/22/medline KW - Default mode network KW - Depression KW - Meditation KW - Mindfulness KW - Religion KW - Spirituality SP - 94 EP - 97 JF - Neuroscience letters JO - Neurosci. Lett. VL - 634 N2 - Individuals at high risk for depression have increased default mode network (DMN) connectivity, as well as reduced inverse connectivity between the DMN and the central executive network (CEN) [8]. Other studies have indicated that the belief in the importance of religion/spirituality (R/S) is protective against depression in high risk individuals [5]. Given these findings, we hypothesized that R/S importance would moderate DMN connectivity, potentially reducing DMN connectivity or increasing DMN-CEN inverse connectivity in individuals at high risk for depression. Using resting-state functional connectivity MRI (rs-fcMRI) in a sample of 104 individuals (aged 11-60) at high and low risk for familial depression, we previously reported increased DMN connectivity and reduced DMN-CEN inverse connectivity in high risk individuals. Here, we found that this effect was moderated by self-report measures of R/S importance. Greater R/S importance in the high risk group was associated with decreased DMN connectivity. These results may represent a protective neural adaptation in the DMN of individuals at high risk for depression, and may have implications for other meditation-based therapies for depression. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/27717831/Religious_and_spiritual_importance_moderate_relation_between_default_mode_network_connectivity_and_familial_risk_for_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(16)30751-0 DB - PRIME DP - Unbound Medicine ER -