Tags

Type your tag names separated by a space and hit enter

Mindfulness-Based Stress Reduction in Post-treatment Breast Cancer Patients: Immediate and Sustained Effects Across Multiple Symptom Clusters.
J Pain Symptom Manage 2017; 53(1):85-95JP

Abstract

CONTEXT

Breast cancer survivors (BCS) face adverse physical and psychological symptoms, often co-occurring. Biologic and psychological factors may link symptoms within clusters, distinguishable by prevalence and/or severity. Few studies have examined the effects of behavioral interventions or treatment of symptom clusters.

OBJECTIVES

The aim of this study was to identify symptom clusters among post-treatment BCS and determine symptom cluster improvement following the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) program.

METHODS

Three hundred twenty-two Stage 0-III post-treatment BCS were randomly assigned to either a six-week MBSR(BC) program or usual care. Psychological (depression, anxiety, stress, and fear of recurrence), physical (fatigue, pain, sleep, and drowsiness), and cognitive symptoms and quality of life were assessed at baseline, six, and 12 weeks, along with demographic and clinical history data at baseline. A three-step analytic process included the error-accounting models of factor analysis and structural equation modeling.

RESULTS

Four symptom clusters emerged at baseline: pain, psychological, fatigue, and cognitive. From baseline to six weeks, the model demonstrated evidence of MBSR(BC) effectiveness in both the psychological (anxiety, depression, perceived stress and QOL, emotional well-being) (P = 0.007) and fatigue (fatigue, sleep, and drowsiness) (P < 0.001) clusters. Results between six and 12 weeks showed sustained effects, but further improvement was not observed.

CONCLUSION

Our results provide clinical effectiveness evidence that MBSR(BC) works to improve symptom clusters, particularly for psychological and fatigue symptom clusters, with the greatest improvement occurring during the six-week program with sustained effects for several weeks after MBSR(BC) training.

TRIAL REGISTRATION

Name and URL of Registry: ClinicalTrials.gov. Registration number: NCT01177124.

Authors+Show Affiliations

Moffitt Cancer Center and Research Institute, Tampa, Florida, USA. Electronic address: rreich@sar.usf.edu.College of Nursing, University of South Florida, Tampa, Florida, USA.College of Nursing, University of South Florida, Tampa, Florida, USA.College of Nursing, University of South Florida, Tampa, Florida, USA.College of Nursing, University of South Florida, Tampa, Florida, USA.College of Nursing, University of South Florida, Tampa, Florida, USA.Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.College of Nursing, University of Florida, Gainesville, Florida, USA.College of Nursing, University of South Florida, Tampa, Florida, USA.Nelda C. Stark College of Nursing, Texas Woman's University, Houston, Texas, USA.University of South Florida Breast Health Clinical and Research Integrated Strategic Program, Tampa, Florida, USA.Department of Surgery, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA.Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

27720794

Citation

Reich, Richard R., et al. "Mindfulness-Based Stress Reduction in Post-treatment Breast Cancer Patients: Immediate and Sustained Effects Across Multiple Symptom Clusters." Journal of Pain and Symptom Management, vol. 53, no. 1, 2017, pp. 85-95.
Reich RR, Lengacher CA, Alinat CB, et al. Mindfulness-Based Stress Reduction in Post-treatment Breast Cancer Patients: Immediate and Sustained Effects Across Multiple Symptom Clusters. J Pain Symptom Manage. 2017;53(1):85-95.
Reich, R. R., Lengacher, C. A., Alinat, C. B., Kip, K. E., Paterson, C., Ramesar, S., ... Park, J. (2017). Mindfulness-Based Stress Reduction in Post-treatment Breast Cancer Patients: Immediate and Sustained Effects Across Multiple Symptom Clusters. Journal of Pain and Symptom Management, 53(1), pp. 85-95. doi:10.1016/j.jpainsymman.2016.08.005.
Reich RR, et al. Mindfulness-Based Stress Reduction in Post-treatment Breast Cancer Patients: Immediate and Sustained Effects Across Multiple Symptom Clusters. J Pain Symptom Manage. 2017;53(1):85-95. PubMed PMID: 27720794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mindfulness-Based Stress Reduction in Post-treatment Breast Cancer Patients: Immediate and Sustained Effects Across Multiple Symptom Clusters. AU - Reich,Richard R, AU - Lengacher,Cecile A, AU - Alinat,Carissa B, AU - Kip,Kevin E, AU - Paterson,Carly, AU - Ramesar,Sophia, AU - Han,Heather S, AU - Ismail-Khan,Roohi, AU - Johnson-Mallard,Versie, AU - Moscoso,Manolete, AU - Budhrani-Shani,Pinky, AU - Shivers,Steve, AU - Cox,Charles E, AU - Goodman,Matthew, AU - Park,Jong, Y1 - 2016/10/05/ PY - 2016/04/20/received PY - 2016/07/05/revised PY - 2016/08/03/accepted PY - 2016/10/11/pubmed PY - 2018/1/13/medline PY - 2016/10/11/entrez KW - Breast cancer KW - Mindfulness-Based Stress Reduction (MBSR) KW - physical symptoms KW - post-treatment KW - psychological symptoms KW - symptom cluster SP - 85 EP - 95 JF - Journal of pain and symptom management JO - J Pain Symptom Manage VL - 53 IS - 1 N2 - CONTEXT: Breast cancer survivors (BCS) face adverse physical and psychological symptoms, often co-occurring. Biologic and psychological factors may link symptoms within clusters, distinguishable by prevalence and/or severity. Few studies have examined the effects of behavioral interventions or treatment of symptom clusters. OBJECTIVES: The aim of this study was to identify symptom clusters among post-treatment BCS and determine symptom cluster improvement following the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) program. METHODS: Three hundred twenty-two Stage 0-III post-treatment BCS were randomly assigned to either a six-week MBSR(BC) program or usual care. Psychological (depression, anxiety, stress, and fear of recurrence), physical (fatigue, pain, sleep, and drowsiness), and cognitive symptoms and quality of life were assessed at baseline, six, and 12 weeks, along with demographic and clinical history data at baseline. A three-step analytic process included the error-accounting models of factor analysis and structural equation modeling. RESULTS: Four symptom clusters emerged at baseline: pain, psychological, fatigue, and cognitive. From baseline to six weeks, the model demonstrated evidence of MBSR(BC) effectiveness in both the psychological (anxiety, depression, perceived stress and QOL, emotional well-being) (P = 0.007) and fatigue (fatigue, sleep, and drowsiness) (P < 0.001) clusters. Results between six and 12 weeks showed sustained effects, but further improvement was not observed. CONCLUSION: Our results provide clinical effectiveness evidence that MBSR(BC) works to improve symptom clusters, particularly for psychological and fatigue symptom clusters, with the greatest improvement occurring during the six-week program with sustained effects for several weeks after MBSR(BC) training. TRIAL REGISTRATION: Name and URL of Registry: ClinicalTrials.gov. Registration number: NCT01177124. SN - 1873-6513 UR - https://www.unboundmedicine.com/medline/citation/27720794/Mindfulness_Based_Stress_Reduction_in_Post_treatment_Breast_Cancer_Patients:_Immediate_and_Sustained_Effects_Across_Multiple_Symptom_Clusters_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0885-3924(16)30333-5 DB - PRIME DP - Unbound Medicine ER -