Tags

Type your tag names separated by a space and hit enter

Helicobacter pylori infection and colorectal carcinoma risk: A meta-analysis.
J Cancer Res Ther. 2016 Oct; 12(Supplement):15-18.JC

Abstract

OBJECTIVE

Helicobacter pylori infection and colorectal cancer risk are not clear. We perform this meta-analysis to further evaluate the association between H. pylori infection and colorectal cancer susceptibility.

METHODS

The databases of CNKI, Wanfang, PubMed, Medline, EMBASE, and HighWire Press were electronic searched by two reviewers independently. The case-control study or cohort study about H. pylori infection and colorectal cancer risk were included in this meta-analysis. The association between H. pylori infection and colorectal cancer risk was evaluated by odds ratio (OR) and corresponding 95% confidence interval (95% CI).

RESULTS

Fourteen case-control studies related to H. pylori infection and colorectal cancer risk were eventually include in this meta-analysis. The pooled results showed that H. pylori infection slight increase the risk of developing colorectal carcinoma (OR = 1.33, 95% CI: 1.01-1.77, P = 0.05). Moreover, Begg's funnel plot demonstrated no significant publication bias.

CONCLUSION

Colorectal carcinoma is associated with H. pylori infection. However, for significant heterogeneity across the studies, this results should be further confirmed by large sample size cohort study.

Authors+Show Affiliations

Department of Chinese and Western Medicine, Tianjin Fourth Center Hospital (Tianjin Medical University Fourth Center Clinical College), Tianjin 300140, P.R. China.Department of Hematology-Oncology, Tianjin Fourth Center Hospital (Tianjin Medical University Fourth Center Clinical College), Tianjin 300140, P.R. China.Department of Gastroenterology, Tianjin Fourth Center Hospital (Tianjin Medical University Fourth Center Clinical College), Tianjin 300140, P.R. China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

27721244

Citation

Zhao, Yang, et al. "Helicobacter Pylori Infection and Colorectal Carcinoma Risk: a Meta-analysis." Journal of Cancer Research and Therapeutics, vol. 12, no. Supplement, 2016, pp. 15-18.
Zhao Y, Wang X, Wang Y. Helicobacter pylori infection and colorectal carcinoma risk: A meta-analysis. J Cancer Res Ther. 2016;12(Supplement):15-18.
Zhao, Y., Wang, X., & Wang, Y. (2016). Helicobacter pylori infection and colorectal carcinoma risk: A meta-analysis. Journal of Cancer Research and Therapeutics, 12(Supplement), 15-18. https://doi.org/10.4103/0973-1482.191621
Zhao Y, Wang X, Wang Y. Helicobacter Pylori Infection and Colorectal Carcinoma Risk: a Meta-analysis. J Cancer Res Ther. 2016;12(Supplement):15-18. PubMed PMID: 27721244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection and colorectal carcinoma risk: A meta-analysis. AU - Zhao,Yang, AU - Wang,Xuli, AU - Wang,Yanrong, PY - 2016/10/11/entrez PY - 2016/10/11/pubmed PY - 2017/3/17/medline SP - 15 EP - 18 JF - Journal of cancer research and therapeutics JO - J Cancer Res Ther VL - 12 IS - Supplement N2 - OBJECTIVE: Helicobacter pylori infection and colorectal cancer risk are not clear. We perform this meta-analysis to further evaluate the association between H. pylori infection and colorectal cancer susceptibility. METHODS: The databases of CNKI, Wanfang, PubMed, Medline, EMBASE, and HighWire Press were electronic searched by two reviewers independently. The case-control study or cohort study about H. pylori infection and colorectal cancer risk were included in this meta-analysis. The association between H. pylori infection and colorectal cancer risk was evaluated by odds ratio (OR) and corresponding 95% confidence interval (95% CI). RESULTS: Fourteen case-control studies related to H. pylori infection and colorectal cancer risk were eventually include in this meta-analysis. The pooled results showed that H. pylori infection slight increase the risk of developing colorectal carcinoma (OR = 1.33, 95% CI: 1.01-1.77, P = 0.05). Moreover, Begg's funnel plot demonstrated no significant publication bias. CONCLUSION: Colorectal carcinoma is associated with H. pylori infection. However, for significant heterogeneity across the studies, this results should be further confirmed by large sample size cohort study. SN - 1998-4138 UR - https://www.unboundmedicine.com/medline/citation/27721244/Helicobacter_pylori_infection_and_colorectal_carcinoma_risk:_A_meta_analysis_ L2 - http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2016;volume=12;issue=5;spage=15;epage=18;aulast=Zhao;type=2 DB - PRIME DP - Unbound Medicine ER -