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Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination.
Pharmaceutics. 2010 Jan 04; 2(1):1-17.P

Abstract

Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time.

Authors+Show Affiliations

Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK.Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK.Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK.School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK.Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK. a.u.r.mohammed@aston.ac.uk.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27721339

Citation

AlHusban, Farhan, et al. "Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination." Pharmaceutics, vol. 2, no. 1, 2010, pp. 1-17.
AlHusban F, ElShaer AM, Kansara JH, et al. Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination. Pharmaceutics. 2010;2(1):1-17.
AlHusban, F., ElShaer, A. M., Kansara, J. H., Smith, A. M., Grover, L. M., Perrie, Y., & Mohammed, A. R. (2010). Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination. Pharmaceutics, 2(1), 1-17.
AlHusban F, et al. Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination. Pharmaceutics. 2010 Jan 4;2(1):1-17. PubMed PMID: 27721339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination. AU - AlHusban,Farhan, AU - ElShaer,Amr M, AU - Kansara,Jiteen H, AU - Smith,Alan M, AU - Grover,Liam M, AU - Perrie,Yvonne, AU - Mohammed,Afzal R, Y1 - 2010/01/04/ PY - 2009/11/26/received PY - 2009/12/15/revised PY - 2009/12/30/accepted PY - 2016/10/11/entrez PY - 2010/1/4/pubmed PY - 2010/1/4/medline KW - annealing KW - lyophilisation KW - orally disintegrating tablets KW - proline KW - serine KW - sublimation rate SP - 1 EP - 17 JF - Pharmaceutics JO - Pharmaceutics VL - 2 IS - 1 N2 - Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time. SN - 1999-4923 UR - https://www.unboundmedicine.com/medline/citation/27721339/Investigation_of_Formulation_and_Process_of_Lyophilised_Orally_Disintegrating_Tablet__ODT__Using_Novel_Amino_Acid_Combination_ L2 - http://www.mdpi.com/resolver?pii=pharmaceutics2010001 DB - PRIME DP - Unbound Medicine ER -
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