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Vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis.
J Bone Miner Metab. 2017 Sep; 35(5):529-535.JB

Abstract

The aim of this study was to evaluate the possible role of vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis (RA). In this study, 42 patients with RA and 40 healthy controls were enrolled. Serum levels of vitamin K homologs were measured using a high-performance liquid chromatography-fluorescence method. Different biochemical and clinical markers for disease activity were measured and correlated with serum levels of vitamin K homologs. There were no significant differences between RA patients and healthy subjects in demographic data. Patients with RA showed significantly higher levels of biochemical markers compared with healthy subjects (p < 0.001). These markers included rheumatoid factor (RF), anticyclic citrullinated polypeptide (anti-CCP), undercarboxylated osteocalcin (ucOC), matrix metalloproteinase (MMP-3), C-reactive protein (CRP), and disease activity score assessing 28 joints with erythrocyte sedimentation rate (DAS28-ESR). In addition, serum levels of vitamin K homologs were reduced in RA patients, and the levels of menaquinone-4 (MK-4) and menaquinone-7 (MK-7) were moderately to strongly inversely correlated with the clinical articular features in RA patients, whereas phylloquinone (PK) levels were weakly correlated. Serum levels of MK-4, MK-7 and PK were strongly inversely correlated with ucOC, MMP-3 and DAS28-ESR in RA patients. In contrast, serum levels of MK-4, MK-7 and PK were weakly correlated with CRP, RF and anti-CCP. These results suggest that serum levels of vitamin K homologs may be considered as potential biomarkers for disease activity. In addition, the results confirm the role of vitamin K deficiency in the etiology of RA.

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Authors+Show Affiliations

Khojah HM
Department of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Al Madinah AlMunawarah, Saudi Arabia. hkhojah@taibahu.edu.sa.
Ahmed S
Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah AlMunawarah, Saudi Arabia.
Abdel-Rahman MS
Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al Madinah AlMunawarah, Saudi Arabia. Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Alkhalil KM
Department of Rheumatology, King Fahd Hospital, Al Madinah AlMunawarah, Saudi Arabia.
Hamza AB
Department of Rheumatology, King Fahd Hospital, Al Madinah AlMunawarah, Saudi Arabia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27722902

Citation

Khojah, Hani M., et al. "Vitamin K Homologs as Potential Biomarkers for Disease Activity in Patients With Rheumatoid Arthritis." Journal of Bone and Mineral Metabolism, vol. 35, no. 5, 2017, pp. 529-535.
Khojah HM, Ahmed S, Abdel-Rahman MS, et al. Vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis. J Bone Miner Metab. 2017;35(5):529-535.
Khojah, H. M., Ahmed, S., Abdel-Rahman, M. S., Alkhalil, K. M., & Hamza, A. B. (2017). Vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis. Journal of Bone and Mineral Metabolism, 35(5), 529-535. https://doi.org/10.1007/s00774-016-0785-4
Khojah HM, et al. Vitamin K Homologs as Potential Biomarkers for Disease Activity in Patients With Rheumatoid Arthritis. J Bone Miner Metab. 2017;35(5):529-535. PubMed PMID: 27722902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis. AU - Khojah,Hani M, AU - Ahmed,Sameh, AU - Abdel-Rahman,Mahran S, AU - Alkhalil,Khaled M, AU - Hamza,Al-Badr, Y1 - 2016/10/08/ PY - 2016/05/11/received PY - 2016/09/05/accepted PY - 2016/10/11/pubmed PY - 2016/10/11/medline PY - 2016/10/11/entrez KW - Biomarkers KW - DAS28-ESR KW - Matrix metalloproteinase KW - Rheumatoid arthritis KW - Vitamin K homologs SP - 529 EP - 535 JF - Journal of bone and mineral metabolism JO - J Bone Miner Metab VL - 35 IS - 5 N2 - The aim of this study was to evaluate the possible role of vitamin K homologs as potential biomarkers for disease activity in patients with rheumatoid arthritis (RA). In this study, 42 patients with RA and 40 healthy controls were enrolled. Serum levels of vitamin K homologs were measured using a high-performance liquid chromatography-fluorescence method. Different biochemical and clinical markers for disease activity were measured and correlated with serum levels of vitamin K homologs. There were no significant differences between RA patients and healthy subjects in demographic data. Patients with RA showed significantly higher levels of biochemical markers compared with healthy subjects (p < 0.001). These markers included rheumatoid factor (RF), anticyclic citrullinated polypeptide (anti-CCP), undercarboxylated osteocalcin (ucOC), matrix metalloproteinase (MMP-3), C-reactive protein (CRP), and disease activity score assessing 28 joints with erythrocyte sedimentation rate (DAS28-ESR). In addition, serum levels of vitamin K homologs were reduced in RA patients, and the levels of menaquinone-4 (MK-4) and menaquinone-7 (MK-7) were moderately to strongly inversely correlated with the clinical articular features in RA patients, whereas phylloquinone (PK) levels were weakly correlated. Serum levels of MK-4, MK-7 and PK were strongly inversely correlated with ucOC, MMP-3 and DAS28-ESR in RA patients. In contrast, serum levels of MK-4, MK-7 and PK were weakly correlated with CRP, RF and anti-CCP. These results suggest that serum levels of vitamin K homologs may be considered as potential biomarkers for disease activity. In addition, the results confirm the role of vitamin K deficiency in the etiology of RA. SN - 1435-5604 UR - https://www.unboundmedicine.com/medline/citation/27722902/Vitamin_K_homologs_as_potential_biomarkers_for_disease_activity_in_patients_with_rheumatoid_arthritis_ DB - PRIME DP - Unbound Medicine ER -