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Medical swab touch spray-mass spectrometry for newborn screening of nicotine and cotinine in meconium.
J Mass Spectrom. 2016 Dec; 51(12):1237-1242.JM

Abstract

Newborn screening is one of public health concerns designed to screen infants shortly after birth. Prenatal exposure to tobacco smoke such as nicotine has been reported to affect babies. Levels of nicotine and cotinine in meconium were widely used to evaluate the tobacco exposure of foetuses during pregnancy in a polluted environment. In this study, medical swabs were applied by using touch spray-mass spectrometry (TS-MS) to collect meconium from newborn infants for detection of nicotine and cotinine. Parameters such as choice of spray solvents, solvent volume and collision energy for screening of nicotine and cotinine were optimized. The limits of detection, reproducibility and matrix effect for analysis of meconium were also investigated. In this study, the levels of nicotine and cotinine in 54 puerpera volunteers were screened by TS-MS and were validated by using traditional liquid chromatography-mass spectrometry. These results showed that medical swab TS-MS would be useful for newborn screening of nicotine and cotinine in meconium with high reproducibility, speed, sensitivity and specificity. The use of disposable medical swabs involves no sample preparation and no chromatographic separation, significantly reducing the cost and time required for screening a large number of clinical sample. Copyright © 2016 John Wiley & Sons, Ltd.

Authors+Show Affiliations

Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, 330006, China.Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, 330006, China.Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, 330006, China.Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, 330006, China.Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, 330006, China.Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, 330006, China.Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, 330006, China.Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, 330006, China.Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, 330006, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27723220

Citation

Yang, Bi-Cheng, et al. "Medical Swab Touch Spray-mass Spectrometry for Newborn Screening of Nicotine and Cotinine in Meconium." Journal of Mass Spectrometry : JMS, vol. 51, no. 12, 2016, pp. 1237-1242.
Yang BC, Wang F, Yang X, et al. Medical swab touch spray-mass spectrometry for newborn screening of nicotine and cotinine in meconium. J Mass Spectrom. 2016;51(12):1237-1242.
Yang, B. C., Wang, F., Yang, X., Zou, W., Wang, J. C., Zou, Y., Liu, F. Y., Liu, H., & Huang, O. P. (2016). Medical swab touch spray-mass spectrometry for newborn screening of nicotine and cotinine in meconium. Journal of Mass Spectrometry : JMS, 51(12), 1237-1242. https://doi.org/10.1002/jms.3892
Yang BC, et al. Medical Swab Touch Spray-mass Spectrometry for Newborn Screening of Nicotine and Cotinine in Meconium. J Mass Spectrom. 2016;51(12):1237-1242. PubMed PMID: 27723220.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medical swab touch spray-mass spectrometry for newborn screening of nicotine and cotinine in meconium. AU - Yang,Bi-Cheng, AU - Wang,Feng, AU - Yang,Xiao, AU - Zou,Wei, AU - Wang,Jia-Chun, AU - Zou,Yang, AU - Liu,Fa-Ying, AU - Liu,Huai, AU - Huang,Ou-Ping, PY - 2016/05/03/received PY - 2016/09/28/revised PY - 2016/10/04/accepted PY - 2016/10/11/pubmed PY - 2018/2/17/medline PY - 2016/10/11/entrez KW - mass spectrometry KW - meconium KW - medical swabs KW - newborn screening KW - touch spray SP - 1237 EP - 1242 JF - Journal of mass spectrometry : JMS JO - J Mass Spectrom VL - 51 IS - 12 N2 - Newborn screening is one of public health concerns designed to screen infants shortly after birth. Prenatal exposure to tobacco smoke such as nicotine has been reported to affect babies. Levels of nicotine and cotinine in meconium were widely used to evaluate the tobacco exposure of foetuses during pregnancy in a polluted environment. In this study, medical swabs were applied by using touch spray-mass spectrometry (TS-MS) to collect meconium from newborn infants for detection of nicotine and cotinine. Parameters such as choice of spray solvents, solvent volume and collision energy for screening of nicotine and cotinine were optimized. The limits of detection, reproducibility and matrix effect for analysis of meconium were also investigated. In this study, the levels of nicotine and cotinine in 54 puerpera volunteers were screened by TS-MS and were validated by using traditional liquid chromatography-mass spectrometry. These results showed that medical swab TS-MS would be useful for newborn screening of nicotine and cotinine in meconium with high reproducibility, speed, sensitivity and specificity. The use of disposable medical swabs involves no sample preparation and no chromatographic separation, significantly reducing the cost and time required for screening a large number of clinical sample. Copyright © 2016 John Wiley & Sons, Ltd. SN - 1096-9888 UR - https://www.unboundmedicine.com/medline/citation/27723220/Medical_swab_touch_spray_mass_spectrometry_for_newborn_screening_of_nicotine_and_cotinine_in_meconium_ DB - PRIME DP - Unbound Medicine ER -