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Efficacy of Probiotic Supplementation Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials.
PLoS One. 2016; 11(10):e0163743.Plos

Abstract

BACKGROUND

Traditional Helicobacter pylori (H. pylori) eradication therapies have shown efficacies below 80% in several studies, and their use has been accompanied by antibiotic-related side effects. Some recent studies have reported that supplementing standard therapies with probiotics can improve the efficacy and tolerability of Helicobacter pylori eradication therapy.

OBJECTIVE

To assess the effects of probiotic supplementation on the eradication rates and therapy-related adverse event rates of anti-Helicobacter pylori regimens.

METHODS

We searched PubMed, Medline, the Cochrane Central Registry of Controlled Trials and the Chinese Biomedical Database for eligible randomized controlled trials published through July, 2015. Review Manager 5.3 was used for all statistical analyses.

RESULTS

Thirteen randomized controlled trials involving a total of 2306 patients were included in our analysis. Intent-to-treat (ITT) analysis performed using a fixed-effects model (test for heterogeneity I2 = 45%) showed that the pooled relative risk (RR) of eradication was significantly higher in the probiotic supplementation group than in the control group [RR 1.15, 95% confidence interval (CI): 1.10-1.20, P<0.00001]. The incidence of total antibiotic-related side effects was lower in the probiotic supplementation group than in the control group, and the pooled RR (studies n = 9) was 0.71 (95% CI: 0.54-0.94, P = 0.02), as determined using a random-effects model (heterogeneity test I2 = 59%). Certain adverse events, such as nausea and vomiting (RR = 0.58, 95% CI 0.35-0.95, P = 0.03), diarrhea (RR = 0.51, 95% CI: 0.31-0.84, P = 0.008) and constipation (RR = 0.47, 95% CI: 0.28-0.80, P = 0.005), were reported at lower rates in the probiotic supplementation group than in the control group. Subgroup analysis showed that eradication rates were significantly improved in both adults (RR = 1.14, 95% CI: 1.09-1.19, P<0.00001) and children (RR = 1.24, 95% CI: 1.05-1.47, P = 0.01) in the probiotic supplementation group and that no regional differences between Europe (RR = 1.17, 95% CI: 1.09-1.24, P<0.00001) and Asia were present (RR = 1.14, 95% CI: 1.06-1.22, P = 0.0002). However, the total adverse event rate was not decreased in the adult group (RR = 0.80, 95% CI: 0.61-1.04, P = 0.1) or the Asian group (RR = 0.68, 95% CI: 0.39-1.18, P = 0.17). Subgroup analyses examining therapy regimens and treatment durations showed that probiotic supplementation increased eradication rates in the triple-therapy (RR = 1.18, 95% CI: 1.12-1.25, P<0.00001), seven-day treatment (RR = 1.21, 95% CI: 1.12-1.31, P<0.00001) and fourteen-day treatment (RR = 1.13, 95% CI: 1.06-1.20, P = 0.0002) groups. The incidence of antibiotic-related side effects was significantly reduced in all groups, with the exception of the quadruple-therapy subgroup (RR = 1.13, 95% CI: 0.60-2.13, P = 0.07) and the fourteen-day therapy subgroup (RR = 0.96, 95% CI 0.61-1.51, P = 0.86). Supplementation with Lactobacillus alone (RR = 1.24, 95% CI: 1.12-1.38, P<0.0001) or multi-strain probiotics (RR = 1.12, 95% CI 1.07-1.18, P<0.00001) was effective at improving H. pylori eradication rates. However, supplementation with Lactobacillus alone did not significantly decrease the overall incidence of side effects (RR = 0.61, 95% CI: 0.11-3.51, P = 0.58). Our study also showed that probiotic supplementation before, during or after H. pylori eradication therapy improved eradication rates, regardless of supplementation duration. Furthermore, probiotic supplementation during H. pylori treatment reduced the incidence of side effects.

CONCLUSION

Probiotic supplementation during anti-Helicobacter pylori treatment may be effective for improving H. pylori eradication rates, minimizing the incidence of therapy-related adverse events and alleviating most disease-related clinical symptoms. However, our results should be interpreted with caution because of the presence of heterogeneity across the trials included in this analysis.

Authors+Show Affiliations

Department of Gastroenterology, the First Affiliated Hospital of Southwest Medical University, Sichuan, People's Republic of China.Department of Gastroenterology, the First Affiliated Hospital of Southwest Medical University, Sichuan, People's Republic of China.School of Foreign Languages, Southwest Medical University, Sichuan, People's Republic of China.Department of Gastroenterology, the First Affiliated Hospital of Southwest Medical University, Sichuan, People's Republic of China.Department of Gastroenterology, the First Affiliated Hospital of Southwest Medical University, Sichuan, People's Republic of China.Department of Gastroenterology, the First Affiliated Hospital of Southwest Medical University, Sichuan, People's Republic of China.Department of Gastroenterology, the First Affiliated Hospital of Southwest Medical University, Sichuan, People's Republic of China.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

27723762

Citation

Lü, Muhan, et al. "Efficacy of Probiotic Supplementation Therapy for Helicobacter Pylori Eradication: a Meta-Analysis of Randomized Controlled Trials." PloS One, vol. 11, no. 10, 2016, pp. e0163743.
Lü M, Yu S, Deng J, et al. Efficacy of Probiotic Supplementation Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials. PLoS ONE. 2016;11(10):e0163743.
Lü, M., Yu, S., Deng, J., Yan, Q., Yang, C., Xia, G., & Zhou, X. (2016). Efficacy of Probiotic Supplementation Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials. PloS One, 11(10), e0163743. https://doi.org/10.1371/journal.pone.0163743
Lü M, et al. Efficacy of Probiotic Supplementation Therapy for Helicobacter Pylori Eradication: a Meta-Analysis of Randomized Controlled Trials. PLoS ONE. 2016;11(10):e0163743. PubMed PMID: 27723762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of Probiotic Supplementation Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials. AU - Lü,Muhan, AU - Yu,Shan, AU - Deng,Jiaqi, AU - Yan,Qiong, AU - Yang,Chun, AU - Xia,Guodong, AU - Zhou,Xian, Y1 - 2016/10/10/ PY - 2016/02/24/received PY - 2016/09/13/accepted PY - 2016/10/11/entrez PY - 2016/10/11/pubmed PY - 2017/4/30/medline SP - e0163743 EP - e0163743 JF - PloS one JO - PLoS ONE VL - 11 IS - 10 N2 - BACKGROUND: Traditional Helicobacter pylori (H. pylori) eradication therapies have shown efficacies below 80% in several studies, and their use has been accompanied by antibiotic-related side effects. Some recent studies have reported that supplementing standard therapies with probiotics can improve the efficacy and tolerability of Helicobacter pylori eradication therapy. OBJECTIVE: To assess the effects of probiotic supplementation on the eradication rates and therapy-related adverse event rates of anti-Helicobacter pylori regimens. METHODS: We searched PubMed, Medline, the Cochrane Central Registry of Controlled Trials and the Chinese Biomedical Database for eligible randomized controlled trials published through July, 2015. Review Manager 5.3 was used for all statistical analyses. RESULTS: Thirteen randomized controlled trials involving a total of 2306 patients were included in our analysis. Intent-to-treat (ITT) analysis performed using a fixed-effects model (test for heterogeneity I2 = 45%) showed that the pooled relative risk (RR) of eradication was significantly higher in the probiotic supplementation group than in the control group [RR 1.15, 95% confidence interval (CI): 1.10-1.20, P<0.00001]. The incidence of total antibiotic-related side effects was lower in the probiotic supplementation group than in the control group, and the pooled RR (studies n = 9) was 0.71 (95% CI: 0.54-0.94, P = 0.02), as determined using a random-effects model (heterogeneity test I2 = 59%). Certain adverse events, such as nausea and vomiting (RR = 0.58, 95% CI 0.35-0.95, P = 0.03), diarrhea (RR = 0.51, 95% CI: 0.31-0.84, P = 0.008) and constipation (RR = 0.47, 95% CI: 0.28-0.80, P = 0.005), were reported at lower rates in the probiotic supplementation group than in the control group. Subgroup analysis showed that eradication rates were significantly improved in both adults (RR = 1.14, 95% CI: 1.09-1.19, P<0.00001) and children (RR = 1.24, 95% CI: 1.05-1.47, P = 0.01) in the probiotic supplementation group and that no regional differences between Europe (RR = 1.17, 95% CI: 1.09-1.24, P<0.00001) and Asia were present (RR = 1.14, 95% CI: 1.06-1.22, P = 0.0002). However, the total adverse event rate was not decreased in the adult group (RR = 0.80, 95% CI: 0.61-1.04, P = 0.1) or the Asian group (RR = 0.68, 95% CI: 0.39-1.18, P = 0.17). Subgroup analyses examining therapy regimens and treatment durations showed that probiotic supplementation increased eradication rates in the triple-therapy (RR = 1.18, 95% CI: 1.12-1.25, P<0.00001), seven-day treatment (RR = 1.21, 95% CI: 1.12-1.31, P<0.00001) and fourteen-day treatment (RR = 1.13, 95% CI: 1.06-1.20, P = 0.0002) groups. The incidence of antibiotic-related side effects was significantly reduced in all groups, with the exception of the quadruple-therapy subgroup (RR = 1.13, 95% CI: 0.60-2.13, P = 0.07) and the fourteen-day therapy subgroup (RR = 0.96, 95% CI 0.61-1.51, P = 0.86). Supplementation with Lactobacillus alone (RR = 1.24, 95% CI: 1.12-1.38, P<0.0001) or multi-strain probiotics (RR = 1.12, 95% CI 1.07-1.18, P<0.00001) was effective at improving H. pylori eradication rates. However, supplementation with Lactobacillus alone did not significantly decrease the overall incidence of side effects (RR = 0.61, 95% CI: 0.11-3.51, P = 0.58). Our study also showed that probiotic supplementation before, during or after H. pylori eradication therapy improved eradication rates, regardless of supplementation duration. Furthermore, probiotic supplementation during H. pylori treatment reduced the incidence of side effects. CONCLUSION: Probiotic supplementation during anti-Helicobacter pylori treatment may be effective for improving H. pylori eradication rates, minimizing the incidence of therapy-related adverse events and alleviating most disease-related clinical symptoms. However, our results should be interpreted with caution because of the presence of heterogeneity across the trials included in this analysis. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27723762/Efficacy_of_Probiotic_Supplementation_Therapy_for_Helicobacter_pylori_Eradication:_A_Meta_Analysis_of_Randomized_Controlled_Trials_ L2 - http://dx.plos.org/10.1371/journal.pone.0163743 DB - PRIME DP - Unbound Medicine ER -