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Maternal diet quality before pregnancy and risk of childhood leukaemia.
Br J Nutr. 2016 Oct; 116(8):1469-1478.BJ

Abstract

Previous studies on maternal nutrition and childhood leukaemia risk have focused on the role of specific nutrients such as folate and have not considered broader measures of diet quality, which may better capture intake of diverse nutrients known to impact fetal development. We examined the relationship between maternal diet quality before pregnancy, as summarised by a diet quality index, and risk of childhood acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in a case-control study in California. Dietary intake in the year before pregnancy was assessed using FFQ in 681 ALL cases, 103 AML cases and 1076 matched controls. Conditional logistic regression was used to estimate OR and 95 % CI for diet quality continuous score and quartiles (Q1-Q4). Higher maternal diet quality score was associated with reduced risk of ALL (OR 0·66; 95 % CI 0·47, 0·93 for Q4 v. Q1) and possibly AML (OR 0·42; 95 % CI 0·15, 1·15 for Q4 v. Q1). No single index component appeared to account for the association. The association of maternal diet quality with risk of ALL was stronger in children diagnosed under the age of 5 years and in children of women who did not report using vitamin supplements before pregnancy. These findings suggest that the joint effects of many dietary components may be important in influencing childhood leukaemia risk.

Authors+Show Affiliations

1Division of Epidemiology,University of California,Berkeley,CA 94720,USA.2Department of Pediatrics,Division of Neonatology and Developmental Medicine,Stanford University School of Medicine,Stanford,CA 94305,USA.1Division of Epidemiology,University of California,Berkeley,CA 94720,USA.3Children's Hospital of Los Angeles,Los Angeles,CA 90027,USA.1Division of Epidemiology,University of California,Berkeley,CA 94720,USA.1Division of Epidemiology,University of California,Berkeley,CA 94720,USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27725005

Citation

Singer, Amanda W., et al. "Maternal Diet Quality Before Pregnancy and Risk of Childhood Leukaemia." The British Journal of Nutrition, vol. 116, no. 8, 2016, pp. 1469-1478.
Singer AW, Carmichael SL, Selvin S, et al. Maternal diet quality before pregnancy and risk of childhood leukaemia. Br J Nutr. 2016;116(8):1469-1478.
Singer, A. W., Carmichael, S. L., Selvin, S., Fu, C., Block, G., & Metayer, C. (2016). Maternal diet quality before pregnancy and risk of childhood leukaemia. The British Journal of Nutrition, 116(8), 1469-1478.
Singer AW, et al. Maternal Diet Quality Before Pregnancy and Risk of Childhood Leukaemia. Br J Nutr. 2016;116(8):1469-1478. PubMed PMID: 27725005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal diet quality before pregnancy and risk of childhood leukaemia. AU - Singer,Amanda W, AU - Carmichael,Suzan L, AU - Selvin,Steve, AU - Fu,Cecilia, AU - Block,Gladys, AU - Metayer,Catherine, Y1 - 2016/10/11/ PY - 2016/10/22/pubmed PY - 2017/5/20/medline PY - 2016/10/12/entrez KW - ALL acute lymphoblastic leukaemia KW - AML acute myeloid leukaemia KW - HEI healthy eating index KW - Childhood leukaemia KW - Diet quality KW - Epidemiology KW - Prenatal nutrition SP - 1469 EP - 1478 JF - The British journal of nutrition JO - Br J Nutr VL - 116 IS - 8 N2 - Previous studies on maternal nutrition and childhood leukaemia risk have focused on the role of specific nutrients such as folate and have not considered broader measures of diet quality, which may better capture intake of diverse nutrients known to impact fetal development. We examined the relationship between maternal diet quality before pregnancy, as summarised by a diet quality index, and risk of childhood acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in a case-control study in California. Dietary intake in the year before pregnancy was assessed using FFQ in 681 ALL cases, 103 AML cases and 1076 matched controls. Conditional logistic regression was used to estimate OR and 95 % CI for diet quality continuous score and quartiles (Q1-Q4). Higher maternal diet quality score was associated with reduced risk of ALL (OR 0·66; 95 % CI 0·47, 0·93 for Q4 v. Q1) and possibly AML (OR 0·42; 95 % CI 0·15, 1·15 for Q4 v. Q1). No single index component appeared to account for the association. The association of maternal diet quality with risk of ALL was stronger in children diagnosed under the age of 5 years and in children of women who did not report using vitamin supplements before pregnancy. These findings suggest that the joint effects of many dietary components may be important in influencing childhood leukaemia risk. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/27725005/Maternal_diet_quality_before_pregnancy_and_risk_of_childhood_leukaemia_ L2 - https://www.cambridge.org/core/product/identifier/S0007114516003469/type/journal_article DB - PRIME DP - Unbound Medicine ER -