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Metabolic syndrome: prevalence and risk factors in Korean gout patients.
Korean J Intern Med. 2018 Jul; 33(4):815-822.KJ

Abstract

BACKGROUND/AIMS

We performed this study to investigate associations between metabolic syndrome, chronic kidney disease (CKD), and gout.

METHODS

We reviewed the medical records of 151 patients with gout at the Department of Rheumatology in Korea University Ansan Hospital. The following measures were examined: waist circumference, blood pressure, alcohol consumption, and levels of triglyceride, high density lipoprotein cholesterol, fasting serum glucose, serum uric acid (SUA), creatinine, insulin, and C-peptide. We assessed metabolic syndrome by the homeostasis model assessment of insulin resistance (HOMA-IR) index and renal function by the Modification of Diet in Renal Disease equation; patients were classified according to World Health Organization Asia-Pacific obesity criteria.

RESULTS

The prevalence of metabolic syndrome in gout patients (50.8%) was higher than in non-gout patients. The mean SUA level was significantly higher in gout patients with metabolic syndrome (9.13 ± 3.15 mg/dL) than in gout patients without metabolic syndrome (8.14 ± 2.07 mg/dL). The mean SUA level was also significantly higher in patients with gout and CKD (9.55 ± 2.86 mg/dL) than in patients with gout but no CKD (7.74 ± 2.27 mg/dL). In gout patients, HOMA-IR was positively correlated with waist circumference (r = 0.409, p = 0.001).

CONCLUSIONS

The prevalence of metabolic syndrome in patients with gout was 50.8%, which is higher than the prevalence in the general Korean population. Hyperuricemia in gout patients was correlated with metabolic syndrome and CKD. Insulin resistance may provide clues to better understand the relationship between metabolic syndrome, CKD, and gout.

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Authors+Show Affiliations

Jung JH
Division of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
Song GG
Division of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
Ji JD
Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Korea.
Lee YH
Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Korea.
Kim JH
Division of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
Seo YH
Division of Rheumatology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.
Choi SJ
Division of Rheumatology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.

MeSH

AdultAgedFemaleGoutHumansInsulin ResistanceMaleMetabolic SyndromeMiddle AgedPrevalenceRepublic of KoreaRisk FactorsUric Acid

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27729624

Citation

Jung, Jae Hyun, et al. "Metabolic Syndrome: Prevalence and Risk Factors in Korean Gout Patients." The Korean Journal of Internal Medicine, vol. 33, no. 4, 2018, pp. 815-822.
Jung JH, Song GG, Ji JD, et al. Metabolic syndrome: prevalence and risk factors in Korean gout patients. Korean J Intern Med. 2018;33(4):815-822.
Jung, J. H., Song, G. G., Ji, J. D., Lee, Y. H., Kim, J. H., Seo, Y. H., & Choi, S. J. (2018). Metabolic syndrome: prevalence and risk factors in Korean gout patients. The Korean Journal of Internal Medicine, 33(4), 815-822. https://doi.org/10.3904/kjim.2016.062
Jung JH, et al. Metabolic Syndrome: Prevalence and Risk Factors in Korean Gout Patients. Korean J Intern Med. 2018;33(4):815-822. PubMed PMID: 27729624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome: prevalence and risk factors in Korean gout patients. AU - Jung,Jae Hyun, AU - Song,Gwan Gyu, AU - Ji,Jong Dae, AU - Lee,Young Ho, AU - Kim,Jae-Hoon, AU - Seo,Young Ho, AU - Choi,Sung Jae, Y1 - 2016/10/12/ PY - 2016/2/26/received PY - 2016/5/23/accepted PY - 2016/10/13/pubmed PY - 2019/3/14/medline PY - 2016/10/13/entrez KW - Gout KW - Insulin resistance KW - Obesity, abdominal KW - Renal insufficiency, chronic KW - Metabolic syndrome SP - 815 EP - 822 JF - The Korean journal of internal medicine JO - Korean J Intern Med VL - 33 IS - 4 N2 - BACKGROUND/AIMS: We performed this study to investigate associations between metabolic syndrome, chronic kidney disease (CKD), and gout. METHODS: We reviewed the medical records of 151 patients with gout at the Department of Rheumatology in Korea University Ansan Hospital. The following measures were examined: waist circumference, blood pressure, alcohol consumption, and levels of triglyceride, high density lipoprotein cholesterol, fasting serum glucose, serum uric acid (SUA), creatinine, insulin, and C-peptide. We assessed metabolic syndrome by the homeostasis model assessment of insulin resistance (HOMA-IR) index and renal function by the Modification of Diet in Renal Disease equation; patients were classified according to World Health Organization Asia-Pacific obesity criteria. RESULTS: The prevalence of metabolic syndrome in gout patients (50.8%) was higher than in non-gout patients. The mean SUA level was significantly higher in gout patients with metabolic syndrome (9.13 ± 3.15 mg/dL) than in gout patients without metabolic syndrome (8.14 ± 2.07 mg/dL). The mean SUA level was also significantly higher in patients with gout and CKD (9.55 ± 2.86 mg/dL) than in patients with gout but no CKD (7.74 ± 2.27 mg/dL). In gout patients, HOMA-IR was positively correlated with waist circumference (r = 0.409, p = 0.001). CONCLUSIONS: The prevalence of metabolic syndrome in patients with gout was 50.8%, which is higher than the prevalence in the general Korean population. Hyperuricemia in gout patients was correlated with metabolic syndrome and CKD. Insulin resistance may provide clues to better understand the relationship between metabolic syndrome, CKD, and gout. SN - 2005-6648 UR - https://www.unboundmedicine.com/medline/citation/27729624/Metabolic_syndrome:_prevalence_and_risk_factors_in_Korean_gout_patients_ DB - PRIME DP - Unbound Medicine ER -