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Is kiwifruit allergy a matter in kiwifruit-cultivating regions? A population-based study.
Pediatr Allergy Immunol 2017; 28(1):38-43PA

Abstract

BACKGROUND

Although kiwifruit is known as a common cause of food allergy, population-based studies concerning the prevalence of kiwifruit allergy do not exist. We aimed to determine the prevalence and clinical characteristics of IgE-mediated kiwifruit allergy in 6-18-year-old urban schoolchildren in a region where kiwifruit is widely cultivated.

METHODS

This cross-sectional study recruited 20,800 of the randomly selected 6-18-year-old urban schoolchildren from the Rize city in the eastern Black Sea region of Turkey during 2013. Following a self-administered questionnaire completed by the parents and the child, consenting children were invited for skin prick tests (SPTs) and oral food challenges (OFCs). Children with suspected IgE-mediated kiwifruit were skin prick tested with kiwifruit (commercial allergen and prick-to-prick test with fresh kiwifruit) and a pre-defined panel of allergens (banana, avocado, latex, sesame seed, birch, timothy, hazel, cat, Dermatophagoides pteronyssinus, and Dermatophagoides farinae). All children with a positive SPT to kiwifruit were invited for an open OFC. The prevalence of IgE-mediated kiwifruit allergy was established using open OFCs.

RESULTS

The response rate to the questionnaire was 75.9% (15783/20800). The estimated prevalence of parental-perceived IgE-mediated kiwifruit allergy was 0.5% (72/15783) (95% CI, 0.39-0.61%). Of the 72 children, 52 (72.2%) were skin tested, and 17 (32.7%) were found to be positive to kiwifruit with both commercial extract and kiwifruit. The most frequently reported symptoms in kiwifruit SPT-positive children were cutaneous (n = 10, 58.8%) followed by gastrointestinal (n = 6, 35.3%) and bronchial (n = 4, 23.5%). Oral symptoms were reported in six (35.3%) children. All children who were kiwifruit positive by SPT were found positive during the oral challenge. The confirmed prevalence of IgE-mediated kiwifruit allergy by means of open OFC in 6-18-year-old urban schoolchildren living in Rize city was 0.10% (95% CI, 0.06-0.16).

CONCLUSION

Prevalence of parental-perceived and clinically confirmed kiwifruit allergy is not consistent. In contrast to expectations, kiwifruit allergy prevalence was low in a city where it is cultivated and highly consumed.

Authors+Show Affiliations

Department of Pediatric Allergy and Immunology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey.Department of Pediatrics, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.Department of Pediatrics, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.Department of Pediatric Allergy and Immunology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27732749

Citation

Haktanir Abul, Mehtap, et al. "Is Kiwifruit Allergy a Matter in Kiwifruit-cultivating Regions? a Population-based Study." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 28, no. 1, 2017, pp. 38-43.
Haktanir Abul M, Dereci S, Hacisalihoglu S, et al. Is kiwifruit allergy a matter in kiwifruit-cultivating regions? A population-based study. Pediatr Allergy Immunol. 2017;28(1):38-43.
Haktanir Abul, M., Dereci, S., Hacisalihoglu, S., & Orhan, F. (2017). Is kiwifruit allergy a matter in kiwifruit-cultivating regions? A population-based study. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 28(1), pp. 38-43. doi:10.1111/pai.12666.
Haktanir Abul M, et al. Is Kiwifruit Allergy a Matter in Kiwifruit-cultivating Regions? a Population-based Study. Pediatr Allergy Immunol. 2017;28(1):38-43. PubMed PMID: 27732749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is kiwifruit allergy a matter in kiwifruit-cultivating regions? A population-based study. AU - Haktanir Abul,Mehtap, AU - Dereci,Selim, AU - Hacisalihoglu,Sadan, AU - Orhan,Fazil, Y1 - 2016/11/23/ PY - 2016/10/09/accepted PY - 2016/10/13/pubmed PY - 2018/1/5/medline PY - 2016/10/13/entrez KW - kiwifruit KW - kiwifruit allergy KW - kiwifruit allergy prevalence SP - 38 EP - 43 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 28 IS - 1 N2 - BACKGROUND: Although kiwifruit is known as a common cause of food allergy, population-based studies concerning the prevalence of kiwifruit allergy do not exist. We aimed to determine the prevalence and clinical characteristics of IgE-mediated kiwifruit allergy in 6-18-year-old urban schoolchildren in a region where kiwifruit is widely cultivated. METHODS: This cross-sectional study recruited 20,800 of the randomly selected 6-18-year-old urban schoolchildren from the Rize city in the eastern Black Sea region of Turkey during 2013. Following a self-administered questionnaire completed by the parents and the child, consenting children were invited for skin prick tests (SPTs) and oral food challenges (OFCs). Children with suspected IgE-mediated kiwifruit were skin prick tested with kiwifruit (commercial allergen and prick-to-prick test with fresh kiwifruit) and a pre-defined panel of allergens (banana, avocado, latex, sesame seed, birch, timothy, hazel, cat, Dermatophagoides pteronyssinus, and Dermatophagoides farinae). All children with a positive SPT to kiwifruit were invited for an open OFC. The prevalence of IgE-mediated kiwifruit allergy was established using open OFCs. RESULTS: The response rate to the questionnaire was 75.9% (15783/20800). The estimated prevalence of parental-perceived IgE-mediated kiwifruit allergy was 0.5% (72/15783) (95% CI, 0.39-0.61%). Of the 72 children, 52 (72.2%) were skin tested, and 17 (32.7%) were found to be positive to kiwifruit with both commercial extract and kiwifruit. The most frequently reported symptoms in kiwifruit SPT-positive children were cutaneous (n = 10, 58.8%) followed by gastrointestinal (n = 6, 35.3%) and bronchial (n = 4, 23.5%). Oral symptoms were reported in six (35.3%) children. All children who were kiwifruit positive by SPT were found positive during the oral challenge. The confirmed prevalence of IgE-mediated kiwifruit allergy by means of open OFC in 6-18-year-old urban schoolchildren living in Rize city was 0.10% (95% CI, 0.06-0.16). CONCLUSION: Prevalence of parental-perceived and clinically confirmed kiwifruit allergy is not consistent. In contrast to expectations, kiwifruit allergy prevalence was low in a city where it is cultivated and highly consumed. SN - 1399-3038 UR - https://www.unboundmedicine.com/medline/citation/27732749/Is_kiwifruit_allergy_a_matter_in_kiwifruit-cultivating_regions_A_population-based_study L2 - https://doi.org/10.1111/pai.12666 DB - PRIME DP - Unbound Medicine ER -