Tags

Type your tag names separated by a space and hit enter

Dihydroisocoumarins from the Mangrove-Derived Fungus Penicillium citrinum.
Mar Drugs. 2016 Oct 10; 14(10)MD

Abstract

Three new dihydroisocoumarin penicimarins G-I (1-3), together with one known dihydroisocoumarin (4) and three known meroterpenoids (5-7), were obtained from a fungus Penicillium citrinum isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of spectroscopic data. The absolute configuration of 1 was determined by the X-ray diffraction analysis using Cu Kα radiation. The absolute configurations of 2 and 3 were determined by comparison of their circular dichroism (CD) spectra with the literature. All compounds were evaluated for their antibacterial activities and cytotoxic activities.

Links

PMC Free PDF

Authors+Show Affiliations

Huang GL
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. huangguolei1982@hainnu.edu.cn.
Zhou XM
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. xueming2009211@126.com.
Bai M
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. xxbai2014@163.com.
Liu YX
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. 18174202788@163.com.
Zhao YL
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. 18689506770@163.com.
Luo YP
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. luoyouping@gmail.com.
Niu YY
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. niuyanyan1986@126.com.
Zheng CJ
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. caijuan2002@163.com.
Chen GY
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China. chgying123@163.com.

MeSH

Anti-Bacterial AgentsAntibiotics, AntineoplasticBacteriaCell Line, TumorCircular DichroismCoumarinsHumansMicrobial Sensitivity TestsMolecular ConformationMolecular StructureNuclear Magnetic Resonance, BiomolecularPenicilliumRhizophoraceaeSpectrometry, Mass, Electrospray IonizationX-Ray Diffraction

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27735855

Citation

Huang, Guo-Lei, et al. "Dihydroisocoumarins From the Mangrove-Derived Fungus Penicillium Citrinum." Marine Drugs, vol. 14, no. 10, 2016.
Huang GL, Zhou XM, Bai M, et al. Dihydroisocoumarins from the Mangrove-Derived Fungus Penicillium citrinum. Mar Drugs. 2016;14(10).
Huang, G. L., Zhou, X. M., Bai, M., Liu, Y. X., Zhao, Y. L., Luo, Y. P., Niu, Y. Y., Zheng, C. J., & Chen, G. Y. (2016). Dihydroisocoumarins from the Mangrove-Derived Fungus Penicillium citrinum. Marine Drugs, 14(10).
Huang GL, et al. Dihydroisocoumarins From the Mangrove-Derived Fungus Penicillium Citrinum. Mar Drugs. 2016 Oct 10;14(10) PubMed PMID: 27735855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dihydroisocoumarins from the Mangrove-Derived Fungus Penicillium citrinum. AU - Huang,Guo-Lei, AU - Zhou,Xue-Ming, AU - Bai,Meng, AU - Liu,Yu-Xin, AU - Zhao,Yan-Lei, AU - Luo,You-Ping, AU - Niu,Yan-Yan, AU - Zheng,Cai-Juan, AU - Chen,Guang-Ying, Y1 - 2016/10/10/ PY - 2016/08/03/received PY - 2016/09/17/revised PY - 2016/09/28/accepted PY - 2016/10/14/entrez PY - 2016/10/14/pubmed PY - 2017/5/24/medline KW - Penicillium citrinum KW - antibacterial activity KW - cytotoxic activity KW - dihydroisocoumarin KW - metabolites JF - Marine drugs JO - Mar Drugs VL - 14 IS - 10 N2 - Three new dihydroisocoumarin penicimarins G-I (1-3), together with one known dihydroisocoumarin (4) and three known meroterpenoids (5-7), were obtained from a fungus Penicillium citrinum isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of spectroscopic data. The absolute configuration of 1 was determined by the X-ray diffraction analysis using Cu Kα radiation. The absolute configurations of 2 and 3 were determined by comparison of their circular dichroism (CD) spectra with the literature. All compounds were evaluated for their antibacterial activities and cytotoxic activities. SN - 1660-3397 UR - https://www.unboundmedicine.com/medline/citation/27735855/Dihydroisocoumarins_from_the_Mangrove_Derived_Fungus_Penicillium_citrinum_ DB - PRIME DP - Unbound Medicine ER -