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IgA1, IgA2 or secretory piece containing antigliadin antibodies in the sera of coeliac patients.
Allergol Immunopathol (Madr). 1989 Mar-Apr; 17(2):77-80.AI

Abstract

A study was made of the gliadin antibodies containing secretory piece (SP) found in 73 sera samples obtained from 38 children with coeliac disease (CD); simultaneously an intestinal biopsy was carried out. In 32 cases the mucosa was flat and the remaining 41, following a gluten-free diet, had a normal intestinal histology. Thirty chronic non-coeliac gastrointestinal patients and 22 normal children were used for a control. An enzymoimmunoassay technique with monoclonal IgA1 and IgA2, and SP polyclonal antibodies was used. The antigliadin antibodies containing SP in serum were above normal limits in 24/32 (75%) active CD patients, but also in 22/41 (54%) patients with normal biopsy and in 20/30 (66%) chronic non-coeliac gastrointestinal patients. There was a multivariant correlation (p less than 0.002) among antigliadin, ovoalbumin and lactoglobulin antibodies containing SP. These results are probably due to non-specific intestinal damage. Nevertheless, antigliadin antibodies containing SP in the sera of gluten-free CD cases lasted longer than antiovoalbumin and antilactoglobulin antibodies. The IgA1 antigliadin antibodies were increased in 19/30 (64%) of active CD patients and 0/8 of inactive CD patients (p less than 0.0005). Nevertheless IgA2 antibodies were increased in only 2/30 (7%) of active CD patients (p less than 0.05). According to this study the IgA antigliadin antibodies in serum are the result of a systemic response, although another interpretation could be that gliadin mainly stimulates IgA1 subclass antibodies in the gut.

Authors+Show Affiliations

Department of Pediatrics, University Hospital, Valladolid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2773754

Citation

Blanco, A, et al. "IgA1, IgA2 or Secretory Piece Containing Antigliadin Antibodies in the Sera of Coeliac Patients." Allergologia Et Immunopathologia, vol. 17, no. 2, 1989, pp. 77-80.
Blanco A, Arranz E, Alonso M, et al. IgA1, IgA2 or secretory piece containing antigliadin antibodies in the sera of coeliac patients. Allergol Immunopathol (Madr). 1989;17(2):77-80.
Blanco, A., Arranz, E., Alonso, M., & Sánchez Villares, E. (1989). IgA1, IgA2 or secretory piece containing antigliadin antibodies in the sera of coeliac patients. Allergologia Et Immunopathologia, 17(2), 77-80.
Blanco A, et al. IgA1, IgA2 or Secretory Piece Containing Antigliadin Antibodies in the Sera of Coeliac Patients. Allergol Immunopathol (Madr). 1989 Mar-Apr;17(2):77-80. PubMed PMID: 2773754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgA1, IgA2 or secretory piece containing antigliadin antibodies in the sera of coeliac patients. AU - Blanco,A, AU - Arranz,E, AU - Alonso,M, AU - Sánchez Villares,E, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez SP - 77 EP - 80 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 17 IS - 2 N2 - A study was made of the gliadin antibodies containing secretory piece (SP) found in 73 sera samples obtained from 38 children with coeliac disease (CD); simultaneously an intestinal biopsy was carried out. In 32 cases the mucosa was flat and the remaining 41, following a gluten-free diet, had a normal intestinal histology. Thirty chronic non-coeliac gastrointestinal patients and 22 normal children were used for a control. An enzymoimmunoassay technique with monoclonal IgA1 and IgA2, and SP polyclonal antibodies was used. The antigliadin antibodies containing SP in serum were above normal limits in 24/32 (75%) active CD patients, but also in 22/41 (54%) patients with normal biopsy and in 20/30 (66%) chronic non-coeliac gastrointestinal patients. There was a multivariant correlation (p less than 0.002) among antigliadin, ovoalbumin and lactoglobulin antibodies containing SP. These results are probably due to non-specific intestinal damage. Nevertheless, antigliadin antibodies containing SP in the sera of gluten-free CD cases lasted longer than antiovoalbumin and antilactoglobulin antibodies. The IgA1 antigliadin antibodies were increased in 19/30 (64%) of active CD patients and 0/8 of inactive CD patients (p less than 0.0005). Nevertheless IgA2 antibodies were increased in only 2/30 (7%) of active CD patients (p less than 0.05). According to this study the IgA antigliadin antibodies in serum are the result of a systemic response, although another interpretation could be that gliadin mainly stimulates IgA1 subclass antibodies in the gut. SN - 0301-0546 UR - https://www.unboundmedicine.com/medline/citation/2773754/IgA1_IgA2_or_secretory_piece_containing_antigliadin_antibodies_in_the_sera_of_coeliac_patients_ L2 - https://medlineplus.gov/celiacdisease.html DB - PRIME DP - Unbound Medicine ER -