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Treatment of Hepatitis E.
Adv Exp Med Biol. 2016; 948:211-221.AE

Abstract

Hepatitis E virus (HEV) infections are the most common cause of acute hepatitis, but they can also take a chronic course. There is no specific therapy for acute hepatitis, and current treatment is supportive. Choosing ribavirin as the first-line therapy for chronic HEV is advisable, especially in solid organ transplant patients. Pegylated interferon-α has been used successfully for treatment of hepatitis E but is associated with major side effects. Cholestasis is one of the most common, but devastating, manifestations in hepatitis E. Current therapy for HEV aims to treat symptoms. Therapy generally involves several measures, such as vitamins for adequate nutrition, albumin and plasma for supporting treatment, symptomatic treatment for cutaneous pruritus, and ursodeoxycholic acid and S-adenosylmethionine, and Traditional Chinese medicine for removing jaundice. Patients with underlying liver disease may develop liver failure. For these patients, supportive treatment is the foundation. Ribavirin has successfully been used to prevent liver transplantation. Prevention and treatment of complications are important for treatment of liver failure. Liver support devices are intended to support liver function until such time as native liver function recovers or until liver transplantation. Liver transplantation is widely considered as irreplaceable and definitive treatment for acute-on-chronic liver failure, particularly for patients who do not improve with supportive measures to sustain life.

Authors+Show Affiliations

Department of Liver Diseases Endocrine, Youan Hospital, Capital Medical University, No. 8 XitoutiaoYouanmenWai, Fengtai District, Beijing, 100069, China. huiwei7701@sina.cn.Department of Liver Diseases Endocrine, Youan Hospital, Capital Medical University, No. 8 XitoutiaoYouanmenWai, Fengtai District, Beijing, 100069, China.Beijing Institute of Liver Disease, No.8 Xitoutiao Youanmen Wai, Fengtai District, Beijing, 100069, China.Department of Liver Diseases Endocrine, Youan Hospital, Capital Medical University, No. 8 XitoutiaoYouanmenWai, Fengtai District, Beijing, 100069, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27738987

Citation

Hui, Wei, et al. "Treatment of Hepatitis E." Advances in Experimental Medicine and Biology, vol. 948, 2016, pp. 211-221.
Hui W, Wei L, Li Z, et al. Treatment of Hepatitis E. Adv Exp Med Biol. 2016;948:211-221.
Hui, W., Wei, L., Li, Z., & Guo, X. (2016). Treatment of Hepatitis E. Advances in Experimental Medicine and Biology, 948, 211-221.
Hui W, et al. Treatment of Hepatitis E. Adv Exp Med Biol. 2016;948:211-221. PubMed PMID: 27738987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of Hepatitis E. AU - Hui,Wei, AU - Wei,Linlin, AU - Li,Zhuo, AU - Guo,Xinhui, PY - 2016/10/15/entrez PY - 2016/10/16/pubmed PY - 2017/9/15/medline KW - Acute hepatitis E KW - Chronic hepatitis E KW - HEV-related liver failure KW - Pegylated interferon KW - Ribavirin KW - Treatment SP - 211 EP - 221 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 948 N2 - Hepatitis E virus (HEV) infections are the most common cause of acute hepatitis, but they can also take a chronic course. There is no specific therapy for acute hepatitis, and current treatment is supportive. Choosing ribavirin as the first-line therapy for chronic HEV is advisable, especially in solid organ transplant patients. Pegylated interferon-α has been used successfully for treatment of hepatitis E but is associated with major side effects. Cholestasis is one of the most common, but devastating, manifestations in hepatitis E. Current therapy for HEV aims to treat symptoms. Therapy generally involves several measures, such as vitamins for adequate nutrition, albumin and plasma for supporting treatment, symptomatic treatment for cutaneous pruritus, and ursodeoxycholic acid and S-adenosylmethionine, and Traditional Chinese medicine for removing jaundice. Patients with underlying liver disease may develop liver failure. For these patients, supportive treatment is the foundation. Ribavirin has successfully been used to prevent liver transplantation. Prevention and treatment of complications are important for treatment of liver failure. Liver support devices are intended to support liver function until such time as native liver function recovers or until liver transplantation. Liver transplantation is widely considered as irreplaceable and definitive treatment for acute-on-chronic liver failure, particularly for patients who do not improve with supportive measures to sustain life. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/27738987/Treatment_of_Hepatitis_E_ L2 - https://dx.doi.org/10.1007/978-94-024-0942-0_12 DB - PRIME DP - Unbound Medicine ER -
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