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Default mode network activity and neuropsychological profile in male children and adolescents with attention deficit hyperactivity disorder and conduct disorder.
Brain Imaging Behav. 2017 Dec; 11(6):1561-1570.BI

Abstract

It is known that patients with Attention Deficit and Hyperactivity disorder (ADHD) and Conduct disorder (CD) commonly shows greater symptom severity than those with ADHD alone and worse outcomes. This study researches whether Default mode network (DMN) is altered in adolescents with ADHD + CD, relative to ADHD alone and controls or not. Ten medication-naïve boys with ADHD + CD, ten medication-naïve boys with ADHD and 10-age-matched typically developing (TD) controls underwent functional magnetic resonance imaging (fMRI) scans in the resting state and neuropsychological tasks such as the Wisconsin Card Sorting Test (WCST), Stroop Test TBAG Form (STP), Auditory Verbal learning Test (AVLT), Visual Auditory Digit Span B (VADS B) were applied to all the subjects included. fMRI scans can be used only nine patients in each groups. The findings revealed group differences between cingulate cortex and primary mortor cortex; cingulate cortex and somatosensory association cortex; angular gyrus (AG) and dorsal posterior cingulate cortex, in these networks increased activity was observed in participants with ADHD + CD compared with the ADHD. We found that lower resting state (rs)-activity was observed between left AG and dorsal posterior cingulate cortex, whereas higher rs-activity connectivity were detected between right AG and somatosensory association cortex in ADHD relative to the ones with ADHD + CD. In neuropsyhcological tasks, ADHD + CD group showed poor performance in WISC-R, WCST, Stroop, AVLT tasks compared to TDs. The ADHD + CD group displayed rs-functional abnormalities in DMN. Our results suggest that abnormalities in the intrinsic activity of resting state networks may contribute to the etiology of CD and poor prognosis of ADHD + CD.

Authors+Show Affiliations

Department of Child and Adolescent Psychiatry, Kayseri Research and Training Hospital, Emel-Mehmet Tarman Child Hospital, Erkilet, Kayseri, Turkey. mervecikili@yahoo.com.Department of Child and Adolescent Psychiatry, Erciyes University, Faculty of Medicine, Kayseri, Turkey.Department of Child and Adolescent Psychiatry, Surp Birgic Armenian Hospital, Istanbul, Turkey.Faculty of Engineering, Biomedical Engineering, Erciyes University, Kayseri, Turkey.Biomedical Imaging Research Center, Erciyes University, Kayseri, Turkey.Department of Child and Adolescent Psychiatry, Erciyes University, Faculty of Medicine, Kayseri, Turkey.Faculty of Medicine, Radiology, Erciyes University, Kayseri, Turkey.Faculty of Engineering, Biomedical Engineering, Erciyes University, Kayseri, Turkey.Department of Child and Adolescent Psychiatry, Erciyes University, Faculty of Medicine, Kayseri, Turkey.Faculty of Medicine, Department of Psychiatry, Erciyes University, Kayseri, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27738997

Citation

Uytun, Merve Cikili, et al. "Default Mode Network Activity and Neuropsychological Profile in Male Children and Adolescents With Attention Deficit Hyperactivity Disorder and Conduct Disorder." Brain Imaging and Behavior, vol. 11, no. 6, 2017, pp. 1561-1570.
Uytun MC, Karakaya E, Oztop DB, et al. Default mode network activity and neuropsychological profile in male children and adolescents with attention deficit hyperactivity disorder and conduct disorder. Brain Imaging Behav. 2017;11(6):1561-1570.
Uytun, M. C., Karakaya, E., Oztop, D. B., Gengec, S., Gumus, K., Ozmen, S., Doğanay, S., Icer, S., Demirci, E., & Ozsoy, S. D. (2017). Default mode network activity and neuropsychological profile in male children and adolescents with attention deficit hyperactivity disorder and conduct disorder. Brain Imaging and Behavior, 11(6), 1561-1570. https://doi.org/10.1007/s11682-016-9614-6
Uytun MC, et al. Default Mode Network Activity and Neuropsychological Profile in Male Children and Adolescents With Attention Deficit Hyperactivity Disorder and Conduct Disorder. Brain Imaging Behav. 2017;11(6):1561-1570. PubMed PMID: 27738997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Default mode network activity and neuropsychological profile in male children and adolescents with attention deficit hyperactivity disorder and conduct disorder. AU - Uytun,Merve Cikili, AU - Karakaya,Emel, AU - Oztop,Didem Behice, AU - Gengec,Serife, AU - Gumus,Kazım, AU - Ozmen,Sevgi, AU - Doğanay,Selim, AU - Icer,Semra, AU - Demirci,Esra, AU - Ozsoy,Saliha Demirel, PY - 2016/10/16/pubmed PY - 2018/7/10/medline PY - 2016/10/15/entrez KW - ADHD KW - Conduct disorder KW - Default mode network KW - Resting state KW - fMRI SP - 1561 EP - 1570 JF - Brain imaging and behavior JO - Brain Imaging Behav VL - 11 IS - 6 N2 - It is known that patients with Attention Deficit and Hyperactivity disorder (ADHD) and Conduct disorder (CD) commonly shows greater symptom severity than those with ADHD alone and worse outcomes. This study researches whether Default mode network (DMN) is altered in adolescents with ADHD + CD, relative to ADHD alone and controls or not. Ten medication-naïve boys with ADHD + CD, ten medication-naïve boys with ADHD and 10-age-matched typically developing (TD) controls underwent functional magnetic resonance imaging (fMRI) scans in the resting state and neuropsychological tasks such as the Wisconsin Card Sorting Test (WCST), Stroop Test TBAG Form (STP), Auditory Verbal learning Test (AVLT), Visual Auditory Digit Span B (VADS B) were applied to all the subjects included. fMRI scans can be used only nine patients in each groups. The findings revealed group differences between cingulate cortex and primary mortor cortex; cingulate cortex and somatosensory association cortex; angular gyrus (AG) and dorsal posterior cingulate cortex, in these networks increased activity was observed in participants with ADHD + CD compared with the ADHD. We found that lower resting state (rs)-activity was observed between left AG and dorsal posterior cingulate cortex, whereas higher rs-activity connectivity were detected between right AG and somatosensory association cortex in ADHD relative to the ones with ADHD + CD. In neuropsyhcological tasks, ADHD + CD group showed poor performance in WISC-R, WCST, Stroop, AVLT tasks compared to TDs. The ADHD + CD group displayed rs-functional abnormalities in DMN. Our results suggest that abnormalities in the intrinsic activity of resting state networks may contribute to the etiology of CD and poor prognosis of ADHD + CD. SN - 1931-7565 UR - https://www.unboundmedicine.com/medline/citation/27738997/Default_mode_network_activity_and_neuropsychological_profile_in_male_children_and_adolescents_with_attention_deficit_hyperactivity_disorder_and_conduct_disorder_ L2 - https://dx.doi.org/10.1007/s11682-016-9614-6 DB - PRIME DP - Unbound Medicine ER -