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Anti-Dermatophyte and Anti-Malassezia Activity of Extracts Rich in Polymeric Flavan-3-ols Obtained from Vitis vinifera Seeds.
Phytother Res. 2017 Jan; 31(1):124-131.PR

Abstract

Several human skin diseases are associated with fungi as dermatophytes and Malassezia. Skin mycoses are increasing and new alternatives to conventional treatments with improved efficacy and/or safety profiles are desirable. For the first time, the anti-dermatophytes and the anti-Malassezia activities of Vitis vinifera seed extracts obtained from different table and wine cultivars have been evaluated. Geometric minimal inhibitory concentration ranged from 20 to 97 µg/mL for dermatophytes and from 32 to 161 µg/mL for Malassezia furfur. Dried grape seed extracts analyzed by HPLC/DAD/ESI/MS showed different quali-quantitative compositions in terms of monomeric and polymeric flavan-3-ols. The minimal inhibitory concentrations for Trichophyton mentagrophytes and for M. furfur were inversely correlated with the amount of the polymeric fraction (r = -0.7639 and r = -0.7228, respectively). Differently, the antifungal activity against T. mentagrophytes was not correlated to the content of flavan-3-ol monomers (r = 0.2920) and only weakly correlated for M. furfur (r = -0.53604). These results suggest that extracts rich in polymeric flavan-3-ols, recovered from V. vinifera seeds, could be used for the treatment of skin fungal infections. Copyright © 2016 John Wiley & Sons, Ltd.

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Authors+Show Affiliations

Simonetti G
Department of Public Health and Infectious Diseases "Sapienza", University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.
D'Auria FD
Department of Public Health and Infectious Diseases "Sapienza", University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.
Mulinacci N
Department of NEUROFARBA, Pharmaceutical and Nutraceutical section, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Firenze, Italy.
Innocenti M
Department of NEUROFARBA, Pharmaceutical and Nutraceutical section, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Firenze, Italy.
Antonacci D
CREA-Council for Agricultural Research and Economics, Research Unit for Table Grapes and Wine Growing in Mediterranean Environment, Via Casamassima 148, 70010, Turi, Bari, Italy.
Angiolella L
Department of Public Health and Infectious Diseases "Sapienza", University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.
Santamaria AR
Department of Environmental Biology "Sapienza", University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.
Valletta A
Department of Environmental Biology "Sapienza", University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.
Donati L
Department of Environmental Biology "Sapienza", University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.
Pasqua G
Department of Environmental Biology "Sapienza", University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

MeSH

Antifungal AgentsChromatography, High Pressure LiquidFlavonoidsMalasseziaPlant ExtractsSeedsVitis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27739110

Citation

Simonetti, Giovanna, et al. "Anti-Dermatophyte and Anti-Malassezia Activity of Extracts Rich in Polymeric Flavan-3-ols Obtained From Vitis Vinifera Seeds." Phytotherapy Research : PTR, vol. 31, no. 1, 2017, pp. 124-131.
Simonetti G, D'Auria FD, Mulinacci N, et al. Anti-Dermatophyte and Anti-Malassezia Activity of Extracts Rich in Polymeric Flavan-3-ols Obtained from Vitis vinifera Seeds. Phytother Res. 2017;31(1):124-131.
Simonetti, G., D'Auria, F. D., Mulinacci, N., Innocenti, M., Antonacci, D., Angiolella, L., Santamaria, A. R., Valletta, A., Donati, L., & Pasqua, G. (2017). Anti-Dermatophyte and Anti-Malassezia Activity of Extracts Rich in Polymeric Flavan-3-ols Obtained from Vitis vinifera Seeds. Phytotherapy Research : PTR, 31(1), 124-131. https://doi.org/10.1002/ptr.5739
Simonetti G, et al. Anti-Dermatophyte and Anti-Malassezia Activity of Extracts Rich in Polymeric Flavan-3-ols Obtained From Vitis Vinifera Seeds. Phytother Res. 2017;31(1):124-131. PubMed PMID: 27739110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-Dermatophyte and Anti-Malassezia Activity of Extracts Rich in Polymeric Flavan-3-ols Obtained from Vitis vinifera Seeds. AU - Simonetti,Giovanna, AU - D'Auria,Felicia Diodata, AU - Mulinacci,Nadia, AU - Innocenti,Marzia, AU - Antonacci,Donato, AU - Angiolella,Letizia, AU - Santamaria,Anna Rita, AU - Valletta,Alessio, AU - Donati,Livia, AU - Pasqua,Gabriella, Y1 - 2016/10/13/ PY - 2016/02/09/received PY - 2016/09/06/revised PY - 2016/09/19/accepted PY - 2016/10/16/pubmed PY - 2017/4/4/medline PY - 2016/10/15/entrez KW - Malassezia furfur KW - Vitaceae KW - antifungal activity KW - dermatophytes KW - grape seed extracts KW - polymeric flavan-3-ols SP - 124 EP - 131 JF - Phytotherapy research : PTR JO - Phytother Res VL - 31 IS - 1 N2 - Several human skin diseases are associated with fungi as dermatophytes and Malassezia. Skin mycoses are increasing and new alternatives to conventional treatments with improved efficacy and/or safety profiles are desirable. For the first time, the anti-dermatophytes and the anti-Malassezia activities of Vitis vinifera seed extracts obtained from different table and wine cultivars have been evaluated. Geometric minimal inhibitory concentration ranged from 20 to 97 µg/mL for dermatophytes and from 32 to 161 µg/mL for Malassezia furfur. Dried grape seed extracts analyzed by HPLC/DAD/ESI/MS showed different quali-quantitative compositions in terms of monomeric and polymeric flavan-3-ols. The minimal inhibitory concentrations for Trichophyton mentagrophytes and for M. furfur were inversely correlated with the amount of the polymeric fraction (r = -0.7639 and r = -0.7228, respectively). Differently, the antifungal activity against T. mentagrophytes was not correlated to the content of flavan-3-ol monomers (r = 0.2920) and only weakly correlated for M. furfur (r = -0.53604). These results suggest that extracts rich in polymeric flavan-3-ols, recovered from V. vinifera seeds, could be used for the treatment of skin fungal infections. Copyright © 2016 John Wiley & Sons, Ltd. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/27739110/Anti_Dermatophyte_and_Anti_Malassezia_Activity_of_Extracts_Rich_in_Polymeric_Flavan_3_ols_Obtained_from_Vitis_vinifera_Seeds_ DB - PRIME DP - Unbound Medicine ER -