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Simultaneous Determination of Food-Related Biogenic Amines and Precursor Amino Acids Using in Situ Derivatization Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction by Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry.
J Agric Food Chem. 2016 Nov 02; 64(43):8225-8234.JA

Abstract

A simple, rapid, sensitive, selective, and environmentally friendly method, based on in situ derivatization ultrasound-assisted dispersive liquid-liquid microextraction (in situ DUADLLME) coupled with ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) using multiple reaction monitoring (MRM) mode has been developed for the simultaneous determination of food-related biogenic amines and amino acids. A new mass-spectrometry-sensitive derivatization reagent 4'-carbonyl chloride rosamine (CCR) was designed, synthesized, and first reported. Parameters and conditions of in situ DUADLLME and UHPLC-MS/MS were optimized in detail. Under the optimized conditions, the in situ DUADLLME was completed speedily (within 1 min) with high derivatization efficiencies (≥98.5%). With the cleanup and concentration of microextraction step, good analytical performance was obtained for the analytes. The results showed that this method was accurate and practical for quantification of biogenic amines and amino acids in common food samples (red wine, beer, wine, cheese, sausage, and fish).

Authors+Show Affiliations

Shandong Provincial Key Laboratory of Life-Organic Analysis & Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University , Qufu 273165, Shandong, People's Republic of China.Shandong Provincial Key Laboratory of Life-Organic Analysis & Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University , Qufu 273165, Shandong, People's Republic of China.Shandong Provincial Key Laboratory of Life-Organic Analysis & Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University , Qufu 273165, Shandong, People's Republic of China.Shandong Provincial Key Laboratory of Life-Organic Analysis & Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University , Qufu 273165, Shandong, People's Republic of China.Qinghai Key Laboratory of Qinghai-Tibet Plateau Biological Resources & Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Science , Xining 810001, Qinghai, People's Republic of China.Qinghai Key Laboratory of Qinghai-Tibet Plateau Biological Resources & Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Science , Xining 810001, Qinghai, People's Republic of China.Shandong Provincial Key Laboratory of Life-Organic Analysis & Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University , Qufu 273165, Shandong, People's Republic of China.National Center for Mass Spectrometry in Changchun & Key Laboratory for Traditional Chinese Medicine Chemistry and Mass Spectrometry of Jilin Province, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun 130022, People's Republic of China.Shandong Provincial Key Laboratory of Life-Organic Analysis & Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University , Qufu 273165, Shandong, People's Republic of China.Shandong Provincial Key Laboratory of Life-Organic Analysis & Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University , Qufu 273165, Shandong, People's Republic of China. Qinghai Key Laboratory of Qinghai-Tibet Plateau Biological Resources & Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Science , Xining 810001, Qinghai, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27739304

Citation

He, Yongrui, et al. "Simultaneous Determination of Food-Related Biogenic Amines and Precursor Amino Acids Using in Situ Derivatization Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction By Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry." Journal of Agricultural and Food Chemistry, vol. 64, no. 43, 2016, pp. 8225-8234.
He Y, Zhao XE, Wang R, et al. Simultaneous Determination of Food-Related Biogenic Amines and Precursor Amino Acids Using in Situ Derivatization Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction by Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry. J Agric Food Chem. 2016;64(43):8225-8234.
He, Y., Zhao, X. E., Wang, R., Wei, N., Sun, J., Dang, J., Chen, G., Liu, Z., Zhu, S., & You, J. (2016). Simultaneous Determination of Food-Related Biogenic Amines and Precursor Amino Acids Using in Situ Derivatization Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction by Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry. Journal of Agricultural and Food Chemistry, 64(43), 8225-8234.
He Y, et al. Simultaneous Determination of Food-Related Biogenic Amines and Precursor Amino Acids Using in Situ Derivatization Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction By Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry. J Agric Food Chem. 2016 Nov 2;64(43):8225-8234. PubMed PMID: 27739304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous Determination of Food-Related Biogenic Amines and Precursor Amino Acids Using in Situ Derivatization Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction by Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry. AU - He,Yongrui, AU - Zhao,Xian-En, AU - Wang,Renjun, AU - Wei,Na, AU - Sun,Jing, AU - Dang,Jun, AU - Chen,Guang, AU - Liu,Zhiqiang, AU - Zhu,Shuyun, AU - You,Jinmao, Y1 - 2016/10/24/ PY - 2016/11/3/pubmed PY - 2017/6/22/medline PY - 2016/10/15/entrez KW - UHPLC-MS/MS (MRM) KW - amino acids KW - biogenic amines KW - in situ derivatization KW - ultrasound-assisted dispersive liquid−liquid microextraction SP - 8225 EP - 8234 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 64 IS - 43 N2 - A simple, rapid, sensitive, selective, and environmentally friendly method, based on in situ derivatization ultrasound-assisted dispersive liquid-liquid microextraction (in situ DUADLLME) coupled with ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) using multiple reaction monitoring (MRM) mode has been developed for the simultaneous determination of food-related biogenic amines and amino acids. A new mass-spectrometry-sensitive derivatization reagent 4'-carbonyl chloride rosamine (CCR) was designed, synthesized, and first reported. Parameters and conditions of in situ DUADLLME and UHPLC-MS/MS were optimized in detail. Under the optimized conditions, the in situ DUADLLME was completed speedily (within 1 min) with high derivatization efficiencies (≥98.5%). With the cleanup and concentration of microextraction step, good analytical performance was obtained for the analytes. The results showed that this method was accurate and practical for quantification of biogenic amines and amino acids in common food samples (red wine, beer, wine, cheese, sausage, and fish). SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/27739304/Simultaneous_Determination_of_Food_Related_Biogenic_Amines_and_Precursor_Amino_Acids_Using_in_Situ_Derivatization_Ultrasound_Assisted_Dispersive_Liquid_Liquid_Microextraction_by_Ultra_High_Performance_Liquid_Chromatography_Tandem_Mass_Spectrometry_ L2 - https://dx.doi.org/10.1021/acs.jafc.6b03536 DB - PRIME DP - Unbound Medicine ER -