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Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome.
Rheum Dis Clin North Am 2016; 42(4):695-710RD

Abstract

Multifocal osteomyelitis and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome constitute a spectrum of disease that includes inflammatory bone lesions and dermatologic findings. Radiographic features resemble those of the spondyloarthropathies with anterior chest wall involvement. Early radiographic findings are osteodestructive with lytic lesions. Bone scintigraphy of the sternoclavicular region classically yields a 'bull's head' pattern of radionuclide uptake. Magnetic resonance imaging (MRI) can demonstrate corner lesions of vertebral bodies. Ultrasound often reveals peripheral enthesitis. Late radiographic features are usually osteoproliferative. PET/CT can identify chronic lesions. Differential diagnostic considerations include osteomyelitis and malignancy, which often prompt bone biopsy.

Authors+Show Affiliations

Division of Rheumatology, Department of Medicine, UMass Memorial Medical Center and University of Massachusetts Medical School, 119 Belmont Street, Worcester, MA 01605, USA.Division of Musculoskeletal Imaging, Department of Radiology, UMass Memorial Medical Center and University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.Division of Rheumatology, Department of Medicine, UMass Memorial Medical Center and University of Massachusetts Medical School, 119 Belmont Street, Worcester, MA 01605, USA. Electronic address: jonathan.kay@umassmemorial.org.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27742022

Citation

Schaub, Steven, et al. "Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome." Rheumatic Diseases Clinics of North America, vol. 42, no. 4, 2016, pp. 695-710.
Schaub S, Sirkis HM, Kay J. Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome. Rheum Dis Clin North Am. 2016;42(4):695-710.
Schaub, S., Sirkis, H. M., & Kay, J. (2016). Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome. Rheumatic Diseases Clinics of North America, 42(4), pp. 695-710. doi:10.1016/j.rdc.2016.07.011.
Schaub S, Sirkis HM, Kay J. Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome. Rheum Dis Clin North Am. 2016;42(4):695-710. PubMed PMID: 27742022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome. AU - Schaub,Steven, AU - Sirkis,Hartley M, AU - Kay,Jonathan, PY - 2016/10/16/entrez PY - 2016/10/16/pubmed PY - 2017/11/10/medline KW - Acne KW - CRMO KW - Hyperostosis KW - Osteitis KW - Palmoplantar pustulosis KW - SAPHO syndrome KW - Vertebral corner lesion KW - ‘Bull's head’ sign SP - 695 EP - 710 JF - Rheumatic diseases clinics of North America JO - Rheum. Dis. Clin. North Am. VL - 42 IS - 4 N2 - Multifocal osteomyelitis and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome constitute a spectrum of disease that includes inflammatory bone lesions and dermatologic findings. Radiographic features resemble those of the spondyloarthropathies with anterior chest wall involvement. Early radiographic findings are osteodestructive with lytic lesions. Bone scintigraphy of the sternoclavicular region classically yields a 'bull's head' pattern of radionuclide uptake. Magnetic resonance imaging (MRI) can demonstrate corner lesions of vertebral bodies. Ultrasound often reveals peripheral enthesitis. Late radiographic features are usually osteoproliferative. PET/CT can identify chronic lesions. Differential diagnostic considerations include osteomyelitis and malignancy, which often prompt bone biopsy. SN - 1558-3163 UR - https://www.unboundmedicine.com/medline/citation/27742022/Imaging_for_Synovitis_Acne_Pustulosis_Hyperostosis_and_Osteitis__SAPHO__Syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-857X(16)30048-5 DB - PRIME DP - Unbound Medicine ER -