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Respiratory reactance in children aged three to five years with postinfectious bronchiolitis obliterans is higher than in those with asthma.
Acta Paediatr 2017; 106(1):81-86AP

Abstract

AIM

We investigated airway function in preschoolers with postinfectious bronchiolitis obliterans (PIBO) using impulse oscillometry (IOS).

METHODS

This study enrolled 182 children aged three to five years: 12 with PIBO, 135 with asthma and 35 nonatopic controls. Respiratory resistance and reactance were assessed using IOS.

RESULTS

The percentage predicted (% predicted) of prebronchodilator respiratory resistance at 5 Hz was significantly higher in children with PIBO (177.9 ± 118.4%) than the asthma (126.1 ± 30.5%, p = 0.013) or control (121.1 ± 21.8%, p = 0.014) groups. After bronchodilator use, children with PIBO did not reach the values of Rrs5% predicted in the asthma and control groups. Respiratory reactance (Xrs5% predicted) in children with PIBO (337.1 ± 478.5%) was significantly higher than both asthma (130.0 ± 80.0%, p = 0.004) and control (105.1 ± 30.8%, p < 0.001) groups before bronchodilator use and significantly higher than the two groups after bronchodilator use (p = 0.010 and p = 0.004, respectively). The changes in Rrs5 and Xrs5 were not significantly different between the children with PIBO and asthma.

CONCLUSION

Measuring Rrs5 and Xrs5 before and after bronchodilator use may help to discriminate PIBO from asthma in children aged three to five years with chronic or recurrent respiratory symptoms.

Authors+Show Affiliations

Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Korea.Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

27743492

Citation

Lee, Eun, et al. "Respiratory Reactance in Children Aged Three to Five Years With Postinfectious Bronchiolitis Obliterans Is Higher Than in Those With Asthma." Acta Paediatrica (Oslo, Norway : 1992), vol. 106, no. 1, 2017, pp. 81-86.
Lee E, Yoon J, Cho HJ, et al. Respiratory reactance in children aged three to five years with postinfectious bronchiolitis obliterans is higher than in those with asthma. Acta Paediatr. 2017;106(1):81-86.
Lee, E., Yoon, J., Cho, H. J., Hong, S. J., & Yu, J. (2017). Respiratory reactance in children aged three to five years with postinfectious bronchiolitis obliterans is higher than in those with asthma. Acta Paediatrica (Oslo, Norway : 1992), 106(1), pp. 81-86. doi:10.1111/apa.13632.
Lee E, et al. Respiratory Reactance in Children Aged Three to Five Years With Postinfectious Bronchiolitis Obliterans Is Higher Than in Those With Asthma. Acta Paediatr. 2017;106(1):81-86. PubMed PMID: 27743492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Respiratory reactance in children aged three to five years with postinfectious bronchiolitis obliterans is higher than in those with asthma. AU - Lee,Eun, AU - Yoon,Jisun, AU - Cho,Hyun-Ju, AU - Hong,Soo-Jong, AU - Yu,Jinho, PY - 2016/05/16/received PY - 2016/08/29/revised PY - 2016/10/12/accepted PY - 2016/10/16/pubmed PY - 2017/3/28/medline PY - 2016/10/16/entrez KW - Asthma KW - Bronchodilator response KW - Impulse oscillometry KW - Postinfectious bronchiolitis obliterans KW - Preschool children SP - 81 EP - 86 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 106 IS - 1 N2 - AIM: We investigated airway function in preschoolers with postinfectious bronchiolitis obliterans (PIBO) using impulse oscillometry (IOS). METHODS: This study enrolled 182 children aged three to five years: 12 with PIBO, 135 with asthma and 35 nonatopic controls. Respiratory resistance and reactance were assessed using IOS. RESULTS: The percentage predicted (% predicted) of prebronchodilator respiratory resistance at 5 Hz was significantly higher in children with PIBO (177.9 ± 118.4%) than the asthma (126.1 ± 30.5%, p = 0.013) or control (121.1 ± 21.8%, p = 0.014) groups. After bronchodilator use, children with PIBO did not reach the values of Rrs5% predicted in the asthma and control groups. Respiratory reactance (Xrs5% predicted) in children with PIBO (337.1 ± 478.5%) was significantly higher than both asthma (130.0 ± 80.0%, p = 0.004) and control (105.1 ± 30.8%, p < 0.001) groups before bronchodilator use and significantly higher than the two groups after bronchodilator use (p = 0.010 and p = 0.004, respectively). The changes in Rrs5 and Xrs5 were not significantly different between the children with PIBO and asthma. CONCLUSION: Measuring Rrs5 and Xrs5 before and after bronchodilator use may help to discriminate PIBO from asthma in children aged three to five years with chronic or recurrent respiratory symptoms. SN - 1651-2227 UR - https://www.unboundmedicine.com/medline/citation/27743492/Respiratory_reactance_in_children_aged_three_to_five_years_with_postinfectious_bronchiolitis_obliterans_is_higher_than_in_those_with_asthma_ L2 - https://doi.org/10.1111/apa.13632 DB - PRIME DP - Unbound Medicine ER -