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Continuous increase of Trichophyton tonsurans as a cause of tinea capitis in the urban area of Paris, France: a 5-year-long study.
Med Mycol. 2017 Jul 01; 55(5):476-484.MM

Abstract

Tinea capitis (TC) is a highly contagious fungal infection of the scalp due to dermatophytes in children. To obtain information on the epidemiology of TC in the urban area of Paris, we analysed the microbiological results of 3090 patients seen with suspected TC from October 2010 to September 2015 at Saint Louis hospital, Paris, France. A peak of TC was observed in 3-6 year-old children, followed by a progressive decrease until 16 years of age. Of the 1311 positive cultures, 95% (1246) yielded one of the three anthropophilic species [Trichophyton tonsurans (33.5%), Trichophyton soudanense (38.3%), or Microsporum audouinii (28.2%)]. When considering one TC case per family, we observed a significant increase of T. tonsurans (P = .018) during these 5 years. The increase was more pronounced (P = .0047) in patients of West-African descent (n = 666), and was at the expense of M. audouinii and T. soudanense. On the other hand, the Caribbean patients (n = 85) remained predominantly (72.9%) infected by T. tonsurans. Our results show a better virulence of T. tonsurans over other species as already reported. Since T. tonsurans has not been reported in Africa, the infection of patients of West-African descent probably took place in the Paris area by exchanges with Caribbean patients. This increase of TC due to T. tonsurans was observed in the context of griseofulvin being the only licensed paediatric treatment for TC in France, which should deserve reappraisal because terbinafine may be more efficacious.

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Authors+Show Affiliations

Gits-Muselli M
Laboratoire de Parasitologie-Mycologie; AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal. Université Paris-Diderot, Sorbonne Paris Cité.
Benderdouche M
Laboratoire de Parasitologie-Mycologie; AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal.
Hamane S
Laboratoire de Parasitologie-Mycologie; AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal.
Mingui A
Laboratoire de Parasitologie-Mycologie; AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal.
Feuilhade de Chauvin M
Laboratoire de Parasitologie-Mycologie; AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal. Université Paris-Diderot, Sorbonne Paris Cité.
Guigue N
Laboratoire de Parasitologie-Mycologie; AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal.
Picat MQ
Service de Biostatistique et Information Médicale, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal.
Bourrat E
Service de dermatologie, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal, AP-HP.
Petit A
Service de dermatologie, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal, AP-HP.
Bagot M
Université Paris-Diderot, Sorbonne Paris Cité. Service de dermatologie, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal, AP-HP.
Alanio A
Laboratoire de Parasitologie-Mycologie; AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal. Université Paris-Diderot, Sorbonne Paris Cité. Inserm U976. Institut Pasteur, Molecular Mycology Unit, National Reference Center of Invasive Mycoses and Antifungals, Paris, France.
Bretagne S
Laboratoire de Parasitologie-Mycologie; AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal. Université Paris-Diderot, Sorbonne Paris Cité. Inserm U976. Institut Pasteur, Molecular Mycology Unit, National Reference Center of Invasive Mycoses and Antifungals, Paris, France.

MeSH

AdolescentAdultAgedAged, 80 and overAntifungal AgentsChildChild, PreschoolFemaleGriseofulvinHumansInfantMaleMicrosporumMiddle AgedNaphthalenesParisRetrospective StudiesTerbinafineTinea CapitisTrichophytonVirulenceYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27744309

Citation

Gits-Muselli, Maud, et al. "Continuous Increase of Trichophyton Tonsurans as a Cause of Tinea Capitis in the Urban Area of Paris, France: a 5-year-long Study." Medical Mycology, vol. 55, no. 5, 2017, pp. 476-484.
Gits-Muselli M, Benderdouche M, Hamane S, et al. Continuous increase of Trichophyton tonsurans as a cause of tinea capitis in the urban area of Paris, France: a 5-year-long study. Med Mycol. 2017;55(5):476-484.
Gits-Muselli, M., Benderdouche, M., Hamane, S., Mingui, A., Feuilhade de Chauvin, M., Guigue, N., Picat, M. Q., Bourrat, E., Petit, A., Bagot, M., Alanio, A., & Bretagne, S. (2017). Continuous increase of Trichophyton tonsurans as a cause of tinea capitis in the urban area of Paris, France: a 5-year-long study. Medical Mycology, 55(5), 476-484. https://doi.org/10.1093/mmy/myw107
Gits-Muselli M, et al. Continuous Increase of Trichophyton Tonsurans as a Cause of Tinea Capitis in the Urban Area of Paris, France: a 5-year-long Study. Med Mycol. 2017 Jul 1;55(5):476-484. PubMed PMID: 27744309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Continuous increase of Trichophyton tonsurans as a cause of tinea capitis in the urban area of Paris, France: a 5-year-long study. AU - Gits-Muselli,Maud, AU - Benderdouche,Mazouz, AU - Hamane,Samia, AU - Mingui,Anselme, AU - Feuilhade de Chauvin,Martine, AU - Guigue,Nicolas, AU - Picat,Marie-Quitterie, AU - Bourrat,Emmanuelle, AU - Petit,Antoine, AU - Bagot,Martine, AU - Alanio,Alexandre, AU - Bretagne,Stéphane, PY - 2016/07/04/received PY - 2016/09/22/accepted PY - 2016/10/17/pubmed PY - 2018/7/6/medline PY - 2016/10/17/entrez KW - Microsporum audouinii var. langeronii KW - Tinea capitis KW - Trichophyton soudanense KW - Trichophyton tonsurans SP - 476 EP - 484 JF - Medical mycology JO - Med Mycol VL - 55 IS - 5 N2 - Tinea capitis (TC) is a highly contagious fungal infection of the scalp due to dermatophytes in children. To obtain information on the epidemiology of TC in the urban area of Paris, we analysed the microbiological results of 3090 patients seen with suspected TC from October 2010 to September 2015 at Saint Louis hospital, Paris, France. A peak of TC was observed in 3-6 year-old children, followed by a progressive decrease until 16 years of age. Of the 1311 positive cultures, 95% (1246) yielded one of the three anthropophilic species [Trichophyton tonsurans (33.5%), Trichophyton soudanense (38.3%), or Microsporum audouinii (28.2%)]. When considering one TC case per family, we observed a significant increase of T. tonsurans (P = .018) during these 5 years. The increase was more pronounced (P = .0047) in patients of West-African descent (n = 666), and was at the expense of M. audouinii and T. soudanense. On the other hand, the Caribbean patients (n = 85) remained predominantly (72.9%) infected by T. tonsurans. Our results show a better virulence of T. tonsurans over other species as already reported. Since T. tonsurans has not been reported in Africa, the infection of patients of West-African descent probably took place in the Paris area by exchanges with Caribbean patients. This increase of TC due to T. tonsurans was observed in the context of griseofulvin being the only licensed paediatric treatment for TC in France, which should deserve reappraisal because terbinafine may be more efficacious. SN - 1460-2709 UR - https://www.unboundmedicine.com/medline/citation/27744309/Continuous_increase_of_Trichophyton_tonsurans_as_a_cause_of_tinea_capitis_in_the_urban_area_of_Paris_France:_a_5_year_long_study_ DB - PRIME DP - Unbound Medicine ER -