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Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer's-like dementia: Involvement of acetylcholinesterase and cell death.
Neurotoxicology. 2016 12; 57:241-250.N

Abstract

The present study aimed to investigate the effects of berberine (BRB) on spatial and learning memory, anxiety, acetylcholinesterase activity and cell death in an experimental model of intracerebroventricular streptozotocin (ICV-STZ) induced sporadic Alzheimer's-like dementia. Sixty male Wistar rats were randomly divided into six groups: control (CTR), BRB 50mg/kg (BRB 50), BRB 100mg/kg (BRB 100), streptozotocin (STZ), streptozotocin plus BRB 50mg/kg (STZ+BRB 50), and streptozotocin plus BRB 100mg/kg (STZ+BRB 100). Rats were injected with ICV-STZ (3mg/kg) or saline, and daily oral BRB treatment began on day 4 for a period of 21days. Behavioral tests were carried out on day 17, and rats were euthanized on day 24. Cell death analysis and determination of acetylcholinesterase activity was performed on the cerebral cortex and hippocampus of the brain. Administration of BRB prevented the memory loss, anxiogenic behavior, increased acetylcholinesterase activity and cell death induced by ICV-STZ. This may be explained, in part, by a protective effect of BRB on ameliorating the progression of neurodegenerative diseases, including Alzheimer's disease, and the results of this study provide a better understanding of the effect of BRB on the brain. Thus, BRB may act as a potential neuroprotective agent.

Authors+Show Affiliations

Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Setor de Bioquímica e Estresse Oxidativo do Laboratório de Terapia Celular, Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address: faha.biomed@hotmail.com.Programa de Pós graduação em Medicina Veterinária, Centro de Ciência Rurais/Departamento de Clínica de Pequenos Animais, Laboratório de Patologia Clínica Veternária/Hospital Veterinário, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Setor de Bioquímica e Estresse Oxidativo do Laboratório de Terapia Celular, Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Laboratório de Neuropsicofarmacologia Universidade Federal de Santa Maria, Santa Maria, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Setor de Bioquímica e Estresse Oxidativo do Laboratório de Terapia Celular, Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Setor de Bioquímica e Estresse Oxidativo do Laboratório de Terapia Celular, Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Laboratório de Neuropsicofarmacologia Universidade Federal de Santa Maria, Santa Maria, Brazil.Programa de Pós Graduação em Ciências Biológicas: Bioquímica Toxicológica, Setor de Bioquímica e Estresse Oxidativo do Laboratório de Terapia Celular, Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.Programa de Pós graduação em Medicina Veterinária, Centro de Ciência Rurais/Departamento de Clínica de Pequenos Animais, Laboratório de Patologia Clínica Veternária/Hospital Veterinário, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address: cmelazzomazzanti@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27746125

Citation

de Oliveira, Juliana Sorraila, et al. "Berberine Protects Against Memory Impairment and Anxiogenic-like Behavior in Rats Submitted to Sporadic Alzheimer's-like Dementia: Involvement of Acetylcholinesterase and Cell Death." Neurotoxicology, vol. 57, 2016, pp. 241-250.
de Oliveira JS, Abdalla FH, Dornelles GL, et al. Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer's-like dementia: Involvement of acetylcholinesterase and cell death. Neurotoxicology. 2016;57:241-250.
de Oliveira, J. S., Abdalla, F. H., Dornelles, G. L., Adefegha, S. A., Palma, T. V., Signor, C., da Silva Bernardi, J., Baldissarelli, J., Lenz, L. S., Magni, L. P., Rubin, M. A., Pillat, M. M., & de Andrade, C. M. (2016). Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer's-like dementia: Involvement of acetylcholinesterase and cell death. Neurotoxicology, 57, 241-250. https://doi.org/10.1016/j.neuro.2016.10.008
de Oliveira JS, et al. Berberine Protects Against Memory Impairment and Anxiogenic-like Behavior in Rats Submitted to Sporadic Alzheimer's-like Dementia: Involvement of Acetylcholinesterase and Cell Death. Neurotoxicology. 2016;57:241-250. PubMed PMID: 27746125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer's-like dementia: Involvement of acetylcholinesterase and cell death. AU - de Oliveira,Juliana Sorraila, AU - Abdalla,Fátima Husein, AU - Dornelles,Guilherme Lopes, AU - Adefegha,Stephen Adeniyi, AU - Palma,Taís Vidal, AU - Signor,Cristiane, AU - da Silva Bernardi,Jamile, AU - Baldissarelli,Jucimara, AU - Lenz,Luana Suéling, AU - Magni,Luana Pereira, AU - Rubin,Maribel Antonello, AU - Pillat,Micheli Mainardi, AU - de Andrade,Cinthia Melazzo, Y1 - 2016/10/13/ PY - 2016/05/31/received PY - 2016/10/10/revised PY - 2016/10/12/accepted PY - 2016/11/5/pubmed PY - 2017/11/29/medline PY - 2016/10/18/entrez KW - Alzheimer’s disease KW - Behavioral tests KW - Berberine KW - Cholinergic system KW - Neuroprotection KW - Streptozotocin SP - 241 EP - 250 JF - Neurotoxicology JO - Neurotoxicology VL - 57 N2 - The present study aimed to investigate the effects of berberine (BRB) on spatial and learning memory, anxiety, acetylcholinesterase activity and cell death in an experimental model of intracerebroventricular streptozotocin (ICV-STZ) induced sporadic Alzheimer's-like dementia. Sixty male Wistar rats were randomly divided into six groups: control (CTR), BRB 50mg/kg (BRB 50), BRB 100mg/kg (BRB 100), streptozotocin (STZ), streptozotocin plus BRB 50mg/kg (STZ+BRB 50), and streptozotocin plus BRB 100mg/kg (STZ+BRB 100). Rats were injected with ICV-STZ (3mg/kg) or saline, and daily oral BRB treatment began on day 4 for a period of 21days. Behavioral tests were carried out on day 17, and rats were euthanized on day 24. Cell death analysis and determination of acetylcholinesterase activity was performed on the cerebral cortex and hippocampus of the brain. Administration of BRB prevented the memory loss, anxiogenic behavior, increased acetylcholinesterase activity and cell death induced by ICV-STZ. This may be explained, in part, by a protective effect of BRB on ameliorating the progression of neurodegenerative diseases, including Alzheimer's disease, and the results of this study provide a better understanding of the effect of BRB on the brain. Thus, BRB may act as a potential neuroprotective agent. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/27746125/Berberine_protects_against_memory_impairment_and_anxiogenic_like_behavior_in_rats_submitted_to_sporadic_Alzheimer's_like_dementia:_Involvement_of_acetylcholinesterase_and_cell_death_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(16)30212-1 DB - PRIME DP - Unbound Medicine ER -