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Influence of grenz rays and psychological factors on experimental pruritus induced by histamine and compound 48/80.
Arch Dermatol Res. 1989; 281(2):111-5.AD

Abstract

The interaction between grenz rays and experimentally induced pruritus was evaluated in 14 healthy subjects. Grenz rays were administered once weekly for 4 weeks on restricted areas of the upper arms. Pruritus was evoked by intradermal injection of histamine and the histamine liberator compound 48/80. The results were compared with unconditioned values and with those obtained following a placebo treatment procedure. The influence of psychosocial and psychosomatic factors was also evaluated. Grenz-ray therapy reduced itch but not flare responses. The influence of grenz rays was, however, not statistically different from that observed after placebo treatment. Psychosocial and psychosomatic factors were good predictors of individual skin responsiveness. The results indicate that grenz rays do not interfere with experimental histamine-induced pruritus more than placebo and emphasize the importance of knowing individual characteristics and coping strategies.

Authors+Show Affiliations

Fjellner B
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Lindelöf B
No affiliation info available
Wahlgren CF
No affiliation info available
Lengstam I
No affiliation info available

MeSH

AdultEpidermisFemaleHistamineHumansMaleMiddle AgedPruritusPsychophysiologic Disordersp-Methoxy-N-methylphenethylamine

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2774639

Citation

Fjellner, B, et al. "Influence of Grenz Rays and Psychological Factors On Experimental Pruritus Induced By Histamine and Compound 48/80." Archives of Dermatological Research, vol. 281, no. 2, 1989, pp. 111-5.
Fjellner B, Lindelöf B, Wahlgren CF, et al. Influence of grenz rays and psychological factors on experimental pruritus induced by histamine and compound 48/80. Arch Dermatol Res. 1989;281(2):111-5.
Fjellner, B., Lindelöf, B., Wahlgren, C. F., & Lengstam, I. (1989). Influence of grenz rays and psychological factors on experimental pruritus induced by histamine and compound 48/80. Archives of Dermatological Research, 281(2), 111-5.
Fjellner B, et al. Influence of Grenz Rays and Psychological Factors On Experimental Pruritus Induced By Histamine and Compound 48/80. Arch Dermatol Res. 1989;281(2):111-5. PubMed PMID: 2774639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of grenz rays and psychological factors on experimental pruritus induced by histamine and compound 48/80. AU - Fjellner,B, AU - Lindelöf,B, AU - Wahlgren,C F, AU - Lengstam,I, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 111 EP - 5 JF - Archives of dermatological research JO - Arch Dermatol Res VL - 281 IS - 2 N2 - The interaction between grenz rays and experimentally induced pruritus was evaluated in 14 healthy subjects. Grenz rays were administered once weekly for 4 weeks on restricted areas of the upper arms. Pruritus was evoked by intradermal injection of histamine and the histamine liberator compound 48/80. The results were compared with unconditioned values and with those obtained following a placebo treatment procedure. The influence of psychosocial and psychosomatic factors was also evaluated. Grenz-ray therapy reduced itch but not flare responses. The influence of grenz rays was, however, not statistically different from that observed after placebo treatment. Psychosocial and psychosomatic factors were good predictors of individual skin responsiveness. The results indicate that grenz rays do not interfere with experimental histamine-induced pruritus more than placebo and emphasize the importance of knowing individual characteristics and coping strategies. SN - 0340-3696 UR - https://www.unboundmedicine.com/medline/citation/2774639/Influence_of_grenz_rays_and_psychological_factors_on_experimental_pruritus_induced_by_histamine_and_compound_48/80_ DB - PRIME DP - Unbound Medicine ER -