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Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China.
Sci Rep 2016; 6:35281SR

Abstract

B vitamins play an essential role in DNA synthesis and methylation, and may protect against oesophageal and gastric cancers. In this case-cohort study, subjects were enrolled from the General Population Nutrition Intervention Trial in Linxian, China. Subjects included 498 oesophageal squamous cell carcinomas (OSCCs), 255 gastric cardia adenocarcinomas (GCAs), and an age- and sex-matched sub-cohort of 947 individuals. Baseline serum riboflavin, pyridoxal phosphate (PLP), folate, vitamin B12, and flavin mononucleotide (FMN) were measured for all subjects. We estimated the associations with Cox proportional hazard models, with adjustment for potential confounders. Compared to those in the lowest quartile of serum riboflavin, those in the highest had a 44% lower risk of OSCC (HR: 0.56, 95% CI: 0.41 to 0.75). Serum vitamin B12 as a continuous variable was observed to be significantly inversely associated with OSCC (HR: 0.95, 95% CI: 0.89 to 1.01, P for score test = 0.041). Higher serum FMN levels were significantly associated with increased risk of OSCC (HR: 1.08, 95% CI: 1.01 to 1.16) and GCA (HR: 1.09, 95% CI: 1.00 to 1.20). Our study prompted that B vitamins have the potential role as chemopreventive agents for upper gastrointestinal cancers.

Authors+Show Affiliations

Program Office for Cancer Screening in Urban China, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.Department of Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.Department of Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27748414

Citation

Ren, Jiansong, et al. "Prospective Study of Serum B Vitamins Levels and Oesophageal and Gastric Cancers in China." Scientific Reports, vol. 6, 2016, p. 35281.
Ren J, Murphy G, Fan J, et al. Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China. Sci Rep. 2016;6:35281.
Ren, J., Murphy, G., Fan, J., Dawsey, S. M., Taylor, P. R., Selhub, J., ... Abnet, C. C. (2016). Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China. Scientific Reports, 6, p. 35281. doi:10.1038/srep35281.
Ren J, et al. Prospective Study of Serum B Vitamins Levels and Oesophageal and Gastric Cancers in China. Sci Rep. 2016 10 17;6:35281. PubMed PMID: 27748414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China. AU - Ren,Jiansong, AU - Murphy,Gwen, AU - Fan,Jinhu, AU - Dawsey,Sanford M, AU - Taylor,Philip R, AU - Selhub,Jacob, AU - Qiao,Youlin, AU - Abnet,Christian C, Y1 - 2016/10/17/ PY - 2016/06/13/received PY - 2016/09/08/accepted PY - 2016/10/18/entrez PY - 2016/10/18/pubmed PY - 2018/5/18/medline SP - 35281 EP - 35281 JF - Scientific reports JO - Sci Rep VL - 6 N2 - B vitamins play an essential role in DNA synthesis and methylation, and may protect against oesophageal and gastric cancers. In this case-cohort study, subjects were enrolled from the General Population Nutrition Intervention Trial in Linxian, China. Subjects included 498 oesophageal squamous cell carcinomas (OSCCs), 255 gastric cardia adenocarcinomas (GCAs), and an age- and sex-matched sub-cohort of 947 individuals. Baseline serum riboflavin, pyridoxal phosphate (PLP), folate, vitamin B12, and flavin mononucleotide (FMN) were measured for all subjects. We estimated the associations with Cox proportional hazard models, with adjustment for potential confounders. Compared to those in the lowest quartile of serum riboflavin, those in the highest had a 44% lower risk of OSCC (HR: 0.56, 95% CI: 0.41 to 0.75). Serum vitamin B12 as a continuous variable was observed to be significantly inversely associated with OSCC (HR: 0.95, 95% CI: 0.89 to 1.01, P for score test = 0.041). Higher serum FMN levels were significantly associated with increased risk of OSCC (HR: 1.08, 95% CI: 1.01 to 1.16) and GCA (HR: 1.09, 95% CI: 1.00 to 1.20). Our study prompted that B vitamins have the potential role as chemopreventive agents for upper gastrointestinal cancers. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/27748414/Prospective_study_of_serum_B_vitamins_levels_and_oesophageal_and_gastric_cancers_in_China_ L2 - http://dx.doi.org/10.1038/srep35281 DB - PRIME DP - Unbound Medicine ER -