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Prevalence of vitamin D deficiency in rheumatoid arthritis and association with disease activity and cardiovascular risk factors: data from the COMEDRA study.
Clin Exp Rheumatol. 2016 Nov-Dec; 34(6):984-990.CE

Abstract

OBJECTIVES

The relationship between vitamin D and rheumatoid arthritis (RA) activity remains controversial. RA is a cardiovascular risk factor. A low level of vitamin D may increase blood pressure (BP) and decrease HDL-cholesterol. We aimed to determine the prevalence of vitamin D deficiency in RA patients compared to controls, and also to investigate the relationship between vitamin D and RA activity, and between vitamin D and cardiovascular risk factors.

METHODS

Patients in the COMEDRA study with established inactive RA (1987 ACR criteria) were matched with subjects from the NUTRINET-SANTE cohort (age, gender, latitude, sampling season). Vitamin D deficiency was defined as <10 ng/mL, and insufficiency as 10 to 29.9 ng/mL.

RESULTS

Eight hundred and ninety-four RA patients were analysed, of which 861 were matched with controls. The prevalence of vitamin D insufficiency and deficiency was lower in RA patients than in controls: 480 (55.8%) vs. 508 (59%) and 31 (3.6%) vs. 45 (5.23%), respectively; p=0.04. There was an inverse correlation between vitamin D levels and RA activity assessed by DAS28-CRP (p=0.01), SDAI (p<0.001) and CDAI (p=0.001), but not DAS28-ESR after adjustment for age, gender, inclusion season, body mass index (BMI), vitamin D supplementation, disease duration, RF or anti-CCP status and RA treatments. Vitamin D levels were inversely correlated with BMI (p<0.001), but not with BP, total cholesterol, LDL-cholesterol, HDL-cholesterol or blood glucose.

CONCLUSIONS

This study demonstrates that vitamin D is inversely correlated with RA activity and BMI, but not with other cardiovascular risk factors.

Authors+Show Affiliations

Cecchetti S
Department of Rheumatology, Clermont-Ferrand University Hospital, France.
Tatar Z
Department of Rheumatology, Clermont-Ferrand University Hospital, France.
Galan P
Paris 13 University, Sorbonne Paris Cité, Nutritional Epidemiology Research Unit, INSERM (U1153), Bobigny, France.
Pereira B
Biostatistics Department, Clermont-Ferrand University Hospital, France.
Lambert C
Biostatistics Department, Clermont-Ferrand University Hospital, France.
Mouterde G
Department of Rheumatology, Lapeyronie Hospital, Montpellier 1 University, EA2415, Montpellier, France.
Sutton A
Biochemistry Department, Jean Verdier Hospital, APHP, Bondy; Paris 13 University, Sorbonne Paris Cité, Laboratory for Vascular Translational Science, INSERM (U1148), Bobigny, France.
Soubrier M
Department of Rheumatology, Clermont-Ferrand University Hospital, France. msoubrier@chu-clermontferrand.fr.
Dougados M
Paris Descartes University, Department of Rheumatology, Hôpital Cochin, Assistance Publique, Hôpitaux de Paris, INSERM (U1153), Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France.

MeSH

AgedArthritis, RheumatoidBiomarkersCardiovascular DiseasesComorbidityFemaleHumansMaleMiddle AgedPrevalenceRisk FactorsSeverity of Illness IndexVitamin DVitamin D Deficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27749232

Citation

Cecchetti, Stella, et al. "Prevalence of Vitamin D Deficiency in Rheumatoid Arthritis and Association With Disease Activity and Cardiovascular Risk Factors: Data From the COMEDRA Study." Clinical and Experimental Rheumatology, vol. 34, no. 6, 2016, pp. 984-990.
Cecchetti S, Tatar Z, Galan P, et al. Prevalence of vitamin D deficiency in rheumatoid arthritis and association with disease activity and cardiovascular risk factors: data from the COMEDRA study. Clin Exp Rheumatol. 2016;34(6):984-990.
Cecchetti, S., Tatar, Z., Galan, P., Pereira, B., Lambert, C., Mouterde, G., Sutton, A., Soubrier, M., & Dougados, M. (2016). Prevalence of vitamin D deficiency in rheumatoid arthritis and association with disease activity and cardiovascular risk factors: data from the COMEDRA study. Clinical and Experimental Rheumatology, 34(6), 984-990.
Cecchetti S, et al. Prevalence of Vitamin D Deficiency in Rheumatoid Arthritis and Association With Disease Activity and Cardiovascular Risk Factors: Data From the COMEDRA Study. Clin Exp Rheumatol. 2016 Nov-Dec;34(6):984-990. PubMed PMID: 27749232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of vitamin D deficiency in rheumatoid arthritis and association with disease activity and cardiovascular risk factors: data from the COMEDRA study. AU - Cecchetti,Stella, AU - Tatar,Zuzana, AU - Galan,Pilar, AU - Pereira,Bruno, AU - Lambert,Céline, AU - Mouterde,Gael, AU - Sutton,Angela, AU - Soubrier,Martin, AU - Dougados,Maxime, Y1 - 2016/09/30/ PY - 2015/11/03/received PY - 2016/01/25/accepted PY - 2016/10/18/pubmed PY - 2017/6/21/medline PY - 2016/10/18/entrez SP - 984 EP - 990 JF - Clinical and experimental rheumatology JO - Clin Exp Rheumatol VL - 34 IS - 6 N2 - OBJECTIVES: The relationship between vitamin D and rheumatoid arthritis (RA) activity remains controversial. RA is a cardiovascular risk factor. A low level of vitamin D may increase blood pressure (BP) and decrease HDL-cholesterol. We aimed to determine the prevalence of vitamin D deficiency in RA patients compared to controls, and also to investigate the relationship between vitamin D and RA activity, and between vitamin D and cardiovascular risk factors. METHODS: Patients in the COMEDRA study with established inactive RA (1987 ACR criteria) were matched with subjects from the NUTRINET-SANTE cohort (age, gender, latitude, sampling season). Vitamin D deficiency was defined as <10 ng/mL, and insufficiency as 10 to 29.9 ng/mL. RESULTS: Eight hundred and ninety-four RA patients were analysed, of which 861 were matched with controls. The prevalence of vitamin D insufficiency and deficiency was lower in RA patients than in controls: 480 (55.8%) vs. 508 (59%) and 31 (3.6%) vs. 45 (5.23%), respectively; p=0.04. There was an inverse correlation between vitamin D levels and RA activity assessed by DAS28-CRP (p=0.01), SDAI (p<0.001) and CDAI (p=0.001), but not DAS28-ESR after adjustment for age, gender, inclusion season, body mass index (BMI), vitamin D supplementation, disease duration, RF or anti-CCP status and RA treatments. Vitamin D levels were inversely correlated with BMI (p<0.001), but not with BP, total cholesterol, LDL-cholesterol, HDL-cholesterol or blood glucose. CONCLUSIONS: This study demonstrates that vitamin D is inversely correlated with RA activity and BMI, but not with other cardiovascular risk factors. SN - 0392-856X UR - https://www.unboundmedicine.com/medline/citation/27749232/Prevalence_of_vitamin_D_deficiency_in_rheumatoid_arthritis_and_association_with_disease_activity_and_cardiovascular_risk_factors:_data_from_the_COMEDRA_study_ DB - PRIME DP - Unbound Medicine ER -