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Primary pulmonary glomus tumor of uncertain malignant potential: A case report with literature review focusing on current concepts of malignancy grade estimation.
Respir Med Case Rep 2016; 19:143-149RM

Abstract

We report a 38-year-old woman with a left lung tumor presenting as obstructive pneumonia. Bronchoscopic examination revealed a polypoid tumor filling the left main bronchus. The tumor was partially resected by a snaring procedure for diagnostic purposes. Microscopic examination revealed a submucosal tumor located underneath normal bronchial epithelium. The tumor was composed of sheets of uniform oval to cuboidal cells encompassing numerous blood vessels. Immunohistochemically, the tumor cells exhibited smooth muscle markers, but were negative for neuroendocrine markers. The diagnosis of primary pulmonary glomus tumor was therefore made. Subsequent bronchoscopic intervention allowed us to pin-point the origin of the tumor: superior segmental B6a/b. She underwent a left lower lobe superior segmental resection successfully. Glomus tumors are relatively rare soft tissue tumors, and those of bronchopulmonary origin are exceedingly rare clinical condition. Among primary lung tumors, the carcinoid tumor is a mimic of the glomus tumor, and differentiating these tumors is known to be difficult, especially using small biopsy samples. In the present case, a large tissue sample obtained by bronchoscopic snaring was quite useful for the correct preoperative diagnosis. Because of the disease rarity, malignancy grade estimation of visceral glomus tumors has not been clearly addressed. Recently, the histopathological diagnostic criteria for malignant glomus tumors was defined in the WHO classification of soft tissue and bone tumors 4th edition. Here we also reviewed the literature on primary bronchopulmonary glomus tumors with special attention to the current concept of malignancy grade estimation.

Authors+Show Affiliations

Department of Pathology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan; Department of Diagnostic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan.Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.Department of Diagnostic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan.Department of Pathology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan; Department of Diagnostic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

27752464

Citation

Oide, Takashi, et al. "Primary Pulmonary Glomus Tumor of Uncertain Malignant Potential: a Case Report With Literature Review Focusing On Current Concepts of Malignancy Grade Estimation." Respiratory Medicine Case Reports, vol. 19, 2016, pp. 143-149.
Oide T, Yasufuku K, Shibuya K, et al. Primary pulmonary glomus tumor of uncertain malignant potential: A case report with literature review focusing on current concepts of malignancy grade estimation. Respir Med Case Rep. 2016;19:143-149.
Oide, T., Yasufuku, K., Shibuya, K., Yoshino, I., Nakatani, Y., & Hiroshima, K. (2016). Primary pulmonary glomus tumor of uncertain malignant potential: A case report with literature review focusing on current concepts of malignancy grade estimation. Respiratory Medicine Case Reports, 19, pp. 143-149.
Oide T, et al. Primary Pulmonary Glomus Tumor of Uncertain Malignant Potential: a Case Report With Literature Review Focusing On Current Concepts of Malignancy Grade Estimation. Respir Med Case Rep. 2016;19:143-149. PubMed PMID: 27752464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary pulmonary glomus tumor of uncertain malignant potential: A case report with literature review focusing on current concepts of malignancy grade estimation. AU - Oide,Takashi, AU - Yasufuku,Kazuhiro, AU - Shibuya,Kiyoshi, AU - Yoshino,Ichiro, AU - Nakatani,Yukio, AU - Hiroshima,Kenzo, Y1 - 2016/10/05/ PY - 2016/08/29/received PY - 2016/10/04/revised PY - 2016/10/04/accepted PY - 2016/10/19/pubmed PY - 2016/10/19/medline PY - 2016/10/19/entrez KW - Bronchoscopy KW - Bronchus KW - Differential diagnosis KW - Glomus tumor KW - Intervention KW - Lung SP - 143 EP - 149 JF - Respiratory medicine case reports JO - Respir Med Case Rep VL - 19 N2 - We report a 38-year-old woman with a left lung tumor presenting as obstructive pneumonia. Bronchoscopic examination revealed a polypoid tumor filling the left main bronchus. The tumor was partially resected by a snaring procedure for diagnostic purposes. Microscopic examination revealed a submucosal tumor located underneath normal bronchial epithelium. The tumor was composed of sheets of uniform oval to cuboidal cells encompassing numerous blood vessels. Immunohistochemically, the tumor cells exhibited smooth muscle markers, but were negative for neuroendocrine markers. The diagnosis of primary pulmonary glomus tumor was therefore made. Subsequent bronchoscopic intervention allowed us to pin-point the origin of the tumor: superior segmental B6a/b. She underwent a left lower lobe superior segmental resection successfully. Glomus tumors are relatively rare soft tissue tumors, and those of bronchopulmonary origin are exceedingly rare clinical condition. Among primary lung tumors, the carcinoid tumor is a mimic of the glomus tumor, and differentiating these tumors is known to be difficult, especially using small biopsy samples. In the present case, a large tissue sample obtained by bronchoscopic snaring was quite useful for the correct preoperative diagnosis. Because of the disease rarity, malignancy grade estimation of visceral glomus tumors has not been clearly addressed. Recently, the histopathological diagnostic criteria for malignant glomus tumors was defined in the WHO classification of soft tissue and bone tumors 4th edition. Here we also reviewed the literature on primary bronchopulmonary glomus tumors with special attention to the current concept of malignancy grade estimation. SN - 2213-0071 UR - https://www.unboundmedicine.com/medline/citation/27752464/Primary_pulmonary_glomus_tumor_of_uncertain_malignant_potential:_A_case_report_with_literature_review_focusing_on_current_concepts_of_malignancy_grade_estimation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2213-0071(16)30138-1 DB - PRIME DP - Unbound Medicine ER -