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Protective Effects of Thymoquinone Against Convulsant Activity Induced by Lithium-Pilocarpine in a model of Status Epilepticus.
Neurochem Res. 2016 Dec; 41(12):3399-3406.NR

Abstract

Inflammation plays a pivotal role in status epilepticus (SE). Thymoquinone (TQ) is a bioactive monomer extracted from black seed (Nigella sativa) oil, which has anti-inflammatory properties in the context of various diseases. This study explored the protective effects of TQ in SE and used a lithium-pilocarpine model of SE to investigate the underlying mechanism, which was related to inflammation mediated by the NF-κB signaling pathway. In the present study, latency to SE increased in the TQ-pretreated group compared with the SE group, and the incidence of SE was significantly reduced. The seizure severity score measured on the Racine scale was significantly decreased in the TQ group compared with the SE group. Moreover, the results of the behavioral tests suggested that TQ may also have a protective effect on learning and memory functions. Finally, we further investigated the protective mechanism of TQ. The results showed that TQ-pretreatment significantly downregulated the protein levels of COX-2 and TNF-α in the brain, in a manner mediated by the NF-κB signaling pathway. These findings demonstrate that TQ attenuates convulsant activity via an anti- inflammation signaling pathway in a model of SE.

Authors+Show Affiliations

Department of Neurology, Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai, 201508, China.Department of Neurology, Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai, 201508, China.Department of Neurology, Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai, 201508, China.Department of Neurology, Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai, 201508, China.Department of Neurology, Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai, 201508, China.Center Laboratory, Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai, 200040, China. libing22@126.com.Department of Neurology, Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai, 201508, China. yinghuichen@fudan.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27752802

Citation

Shao, Yiye, et al. "Protective Effects of Thymoquinone Against Convulsant Activity Induced By Lithium-Pilocarpine in a Model of Status Epilepticus." Neurochemical Research, vol. 41, no. 12, 2016, pp. 3399-3406.
Shao Y, Feng Y, Xie Y, et al. Protective Effects of Thymoquinone Against Convulsant Activity Induced by Lithium-Pilocarpine in a model of Status Epilepticus. Neurochem Res. 2016;41(12):3399-3406.
Shao, Y., Feng, Y., Xie, Y., Luo, Q., Chen, L., Li, B., & Chen, Y. (2016). Protective Effects of Thymoquinone Against Convulsant Activity Induced by Lithium-Pilocarpine in a model of Status Epilepticus. Neurochemical Research, 41(12), 3399-3406.
Shao Y, et al. Protective Effects of Thymoquinone Against Convulsant Activity Induced By Lithium-Pilocarpine in a Model of Status Epilepticus. Neurochem Res. 2016;41(12):3399-3406. PubMed PMID: 27752802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective Effects of Thymoquinone Against Convulsant Activity Induced by Lithium-Pilocarpine in a model of Status Epilepticus. AU - Shao,Yiye, AU - Feng,Yonghao, AU - Xie,Yangmei, AU - Luo,Qiong, AU - Chen,Long, AU - Li,Bing, AU - Chen,Yinghui, Y1 - 2016/10/18/ PY - 2016/05/25/received PY - 2016/09/26/accepted PY - 2016/09/08/revised PY - 2016/10/19/pubmed PY - 2017/3/16/medline PY - 2016/10/19/entrez KW - Convulsant activity KW - Inflammation KW - NF-κB KW - Status epilepticus KW - Thymoquinone SP - 3399 EP - 3406 JF - Neurochemical research JO - Neurochem. Res. VL - 41 IS - 12 N2 - Inflammation plays a pivotal role in status epilepticus (SE). Thymoquinone (TQ) is a bioactive monomer extracted from black seed (Nigella sativa) oil, which has anti-inflammatory properties in the context of various diseases. This study explored the protective effects of TQ in SE and used a lithium-pilocarpine model of SE to investigate the underlying mechanism, which was related to inflammation mediated by the NF-κB signaling pathway. In the present study, latency to SE increased in the TQ-pretreated group compared with the SE group, and the incidence of SE was significantly reduced. The seizure severity score measured on the Racine scale was significantly decreased in the TQ group compared with the SE group. Moreover, the results of the behavioral tests suggested that TQ may also have a protective effect on learning and memory functions. Finally, we further investigated the protective mechanism of TQ. The results showed that TQ-pretreatment significantly downregulated the protein levels of COX-2 and TNF-α in the brain, in a manner mediated by the NF-κB signaling pathway. These findings demonstrate that TQ attenuates convulsant activity via an anti- inflammation signaling pathway in a model of SE. SN - 1573-6903 UR - https://www.unboundmedicine.com/medline/citation/27752802/Protective_Effects_of_Thymoquinone_Against_Convulsant_Activity_Induced_by_Lithium_Pilocarpine_in_a_model_of_Status_Epilepticus_ L2 - https://doi.org/10.1007/s11064-016-2074-y DB - PRIME DP - Unbound Medicine ER -