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Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults.
Mol Biol Rep 2016; 43(12):1359-1369MB

Abstract

There is scarce information about the link between specific single-nucleotide polymorphisms (SNPs) and risk of liver disease among Latinos, despite the disproportionate burden of disease among this population. Our aim was to investigate nine SNPs in or near the following genes: PNPLA3, LYPLAL1, PPP1R3B, GCKR, NCAN, IRS1, PPARG, and ADIPOR2 and examine their association with persistently elevated alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels in Mexican adults. Data and samples were collected from 741 participants in the Mexican Health Worker Cohort Study, in Cuernavaca, Mexico. We identified 207 cases who had persistently elevated levels of ALT or AST (≥40 U/L) and 534 controls with at least two consecutive normal ALT or AST results in a 6 month period, during 2004-2006 and 2011-2013. TaqMan assays were used to genotype the SNPs. The risk allele of PNPLA3 rs738409 was found to be associated with persistently elevated levels of ALT or AST, adjusting for age, sex, BMI, type 2 diabetes, and ancestry: (OR 2.28, 95 % CI 1.13, 4.58). A significant association was found between the LYPLAL1, PPP1R3B, and GCKR risk alleles and elevated ALT or AST levels among overweight/obese adults. These results suggest that among Mexicans, the PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), and GCKR (rs780094) polymorphisms may be associated with a greater risk of chronic liver disease among overweight adults. This study is the first to examine these nine SNPs in a sample of adults in Mexico.

Authors+Show Affiliations

Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social (IMSS), Blvd. Benito Juárez No. 31 Col. Centro, Cuernavaca, Morelos, Mexico. ynflores@ucla.edu. UCLA Department of Health Policy and Management, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA. ynflores@ucla.edu.Instituto Nacional de Medicina Genómica, Periférico Sur No. 4809, Col. Arenal Tepepan, Mexico, DF, Mexico.Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social (IMSS), Blvd. Benito Juárez No. 31 Col. Centro, Cuernavaca, Morelos, Mexico.Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social (IMSS), Blvd. Benito Juárez No. 31 Col. Centro, Cuernavaca, Morelos, Mexico. Instituto Nacional de Medicina Genómica, Periférico Sur No. 4809, Col. Arenal Tepepan, Mexico, DF, Mexico.UCLA Department of Epidemiology, Fielding School of Public Health, Los Angeles, CA, USA.Los Angeles County Department of Health Services, 313 Figueroa, Los Angeles, CA, USA.UCLA Department of Epidemiology, Fielding School of Public Health, Los Angeles, CA, USA.Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM/Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.Clínica de Hígado, IMSS Hospital General Regional con UMF 1, Av. Plan de Ayala 1201, Flores Magon, Cuernavaca, Morelos, Mexico.Instituto Nacional de Medicina Genómica, Periférico Sur No. 4809, Col. Arenal Tepepan, Mexico, DF, Mexico.Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social (IMSS), Blvd. Benito Juárez No. 31 Col. Centro, Cuernavaca, Morelos, Mexico. Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27752939

Citation

Flores, Yvonne N., et al. "Association Between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and Elevated Transaminase Levels in Overweight/obese Mexican Adults." Molecular Biology Reports, vol. 43, no. 12, 2016, pp. 1359-1369.
Flores YN, Velázquez-Cruz R, Ramírez P, et al. Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults. Mol Biol Rep. 2016;43(12):1359-1369.
Flores, Y. N., Velázquez-Cruz, R., Ramírez, P., Bañuelos, M., Zhang, Z. F., Yee, H. F., ... Salmerón, J. (2016). Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults. Molecular Biology Reports, 43(12), pp. 1359-1369.
Flores YN, et al. Association Between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and Elevated Transaminase Levels in Overweight/obese Mexican Adults. Mol Biol Rep. 2016;43(12):1359-1369. PubMed PMID: 27752939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults. AU - Flores,Yvonne N, AU - Velázquez-Cruz,Rafael, AU - Ramírez,Paula, AU - Bañuelos,Manuel, AU - Zhang,Zuo-Feng, AU - Yee,Hal F,Jr AU - Chang,Shen-Chih, AU - Canizales-Quinteros,Samuel, AU - Quiterio,Manuel, AU - Cabrera-Alvarez,Guillermo, AU - Patiño,Nelly, AU - Salmerón,Jorge, Y1 - 2016/10/17/ PY - 2015/11/27/received PY - 2016/08/16/accepted PY - 2016/10/19/pubmed PY - 2017/2/14/medline PY - 2016/10/19/entrez KW - Alanine aminotransferase (ALT) KW - Aspartate aminotransferase (AST) KW - Candidate gene study KW - Latinos KW - Mexican adults KW - Nonalcoholic fatty liver disease SP - 1359 EP - 1369 JF - Molecular biology reports JO - Mol. Biol. Rep. VL - 43 IS - 12 N2 - There is scarce information about the link between specific single-nucleotide polymorphisms (SNPs) and risk of liver disease among Latinos, despite the disproportionate burden of disease among this population. Our aim was to investigate nine SNPs in or near the following genes: PNPLA3, LYPLAL1, PPP1R3B, GCKR, NCAN, IRS1, PPARG, and ADIPOR2 and examine their association with persistently elevated alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels in Mexican adults. Data and samples were collected from 741 participants in the Mexican Health Worker Cohort Study, in Cuernavaca, Mexico. We identified 207 cases who had persistently elevated levels of ALT or AST (≥40 U/L) and 534 controls with at least two consecutive normal ALT or AST results in a 6 month period, during 2004-2006 and 2011-2013. TaqMan assays were used to genotype the SNPs. The risk allele of PNPLA3 rs738409 was found to be associated with persistently elevated levels of ALT or AST, adjusting for age, sex, BMI, type 2 diabetes, and ancestry: (OR 2.28, 95 % CI 1.13, 4.58). A significant association was found between the LYPLAL1, PPP1R3B, and GCKR risk alleles and elevated ALT or AST levels among overweight/obese adults. These results suggest that among Mexicans, the PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), and GCKR (rs780094) polymorphisms may be associated with a greater risk of chronic liver disease among overweight adults. This study is the first to examine these nine SNPs in a sample of adults in Mexico. SN - 1573-4978 UR - https://www.unboundmedicine.com/medline/citation/27752939/Association_between_PNPLA3__rs738409__LYPLAL1__rs12137855__PPP1R3B__rs4240624__GCKR__rs780094__and_elevated_transaminase_levels_in_overweight/obese_Mexican_adults_ L2 - https://doi.org/10.1007/s11033-016-4058-z DB - PRIME DP - Unbound Medicine ER -