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The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort.
Br J Nutr. 2016 Oct; 116(8):1409-1415.BJ

Abstract

Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Controversy remains as findings have been inconsistent between disparate populations. The aim of this study was to investigate the relationship between vitamin D status and pregnancy outcomes in a large, prospective pregnancy cohort. 25-Hydroxyvitamin D concentration was analysed in serum samples collected at 15 weeks of gestation from 1710 New Zealand women participating in a large, observational study. Associations between vitamin D status and pre-eclampsia, preterm birth, small for gestational age (SGA) and gestational diabetes were investigated. The mean 25-hydroxyvitamin D concentration was 72·9 nmol/l. In all, 23 % had 25-hydroxyvitamin D concentrations 75 nmol/l (OR 2·3; 95 % CI 1·1, 5·1). However, this effect was not significant when adjustments were made for BMI and ethnicity (OR 1·8; 95 % CI 0·8, 4·2). 25-Hydroxyvitamin D concentration at 15 weeks was not associated with development of pre-eclampsia, spontaneous preterm birth or SGA infants. Pregnancy complications were low in this largely vitamin D-replete population.

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Authors+Show Affiliations

Boyle VT
1Gravida: National Centre for Growth and Development,The Liggins Institute,The University of Auckland,Auckland 1023,New Zealand.
Thorstensen EB
1Gravida: National Centre for Growth and Development,The Liggins Institute,The University of Auckland,Auckland 1023,New Zealand.
Mourath D
2Medical Program,Linköping University,Linköping, SE-581 83,Sweden.
Jones MB
3Institute of Natural and Mathematical Sciences,Massey University,Auckland 0632,New Zealand.
McCowan LM
4The Department of Obstetrics and Gynaecology,South Auckland Clinical School,The University of Auckland,Auckland 1023,New Zealand.
Kenny LC
5The Irish Centre for Fetal and Neonatal Translational Research (INFANT) and the Department of Obstetrics and Gynaecology,University College Cork,Cork,Ireland.
Baker PN
1Gravida: National Centre for Growth and Development,The Liggins Institute,The University of Auckland,Auckland 1023,New Zealand.

MeSH

25-Hydroxyvitamin D 2BiomarkersCalcifediolCohort StudiesDiabetes, GestationalFemaleFetal Growth RetardationHumansIncidenceMaternal Nutritional Physiological PhenomenaNew ZealandNutritional StatusPre-EclampsiaPregnancyPregnancy ComplicationsPregnancy OutcomePregnancy Trimester, SecondPremature BirthPrevalenceProspective StudiesRiskSeverity of Illness IndexVitamin D Deficiency

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

27753425

Citation

Boyle, Veronica T., et al. "The Relationship Between 25-hydroxyvitamin D Concentration in Early Pregnancy and Pregnancy Outcomes in a Large, Prospective Cohort." The British Journal of Nutrition, vol. 116, no. 8, 2016, pp. 1409-1415.
Boyle VT, Thorstensen EB, Mourath D, et al. The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort. Br J Nutr. 2016;116(8):1409-1415.
Boyle, V. T., Thorstensen, E. B., Mourath, D., Jones, M. B., McCowan, L. M., Kenny, L. C., & Baker, P. N. (2016). The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort. The British Journal of Nutrition, 116(8), 1409-1415.
Boyle VT, et al. The Relationship Between 25-hydroxyvitamin D Concentration in Early Pregnancy and Pregnancy Outcomes in a Large, Prospective Cohort. Br J Nutr. 2016;116(8):1409-1415. PubMed PMID: 27753425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort. AU - Boyle,Veronica T, AU - Thorstensen,Eric B, AU - Mourath,David, AU - Jones,M Beatrix, AU - McCowan,Lesley M E, AU - Kenny,Louise C, AU - Baker,Philip N, Y1 - 2016/10/18/ PY - 2016/10/22/pubmed PY - 2017/5/20/medline PY - 2016/10/22/entrez KW - GDM gestational diabetes mellitus KW - NZ New Zealand KW - SCOPE Screening for Pregnancy Endpoints study KW - SGA small for gestational age KW - Gestational diabetes mellitus KW - Pre-eclampsia KW - Vitamin D SP - 1409 EP - 1415 JF - The British journal of nutrition JO - Br J Nutr VL - 116 IS - 8 N2 - Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Controversy remains as findings have been inconsistent between disparate populations. The aim of this study was to investigate the relationship between vitamin D status and pregnancy outcomes in a large, prospective pregnancy cohort. 25-Hydroxyvitamin D concentration was analysed in serum samples collected at 15 weeks of gestation from 1710 New Zealand women participating in a large, observational study. Associations between vitamin D status and pre-eclampsia, preterm birth, small for gestational age (SGA) and gestational diabetes were investigated. The mean 25-hydroxyvitamin D concentration was 72·9 nmol/l. In all, 23 % had 25-hydroxyvitamin D concentrations 75 nmol/l (OR 2·3; 95 % CI 1·1, 5·1). However, this effect was not significant when adjustments were made for BMI and ethnicity (OR 1·8; 95 % CI 0·8, 4·2). 25-Hydroxyvitamin D concentration at 15 weeks was not associated with development of pre-eclampsia, spontaneous preterm birth or SGA infants. Pregnancy complications were low in this largely vitamin D-replete population. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/27753425/The_relationship_between_25_hydroxyvitamin_D_concentration_in_early_pregnancy_and_pregnancy_outcomes_in_a_large_prospective_cohort_ L2 - https://www.cambridge.org/core/product/identifier/S0007114516003202/type/journal_article DB - PRIME DP - Unbound Medicine ER -