Tags

Type your tag names separated by a space and hit enter

Enhanced working memory performance via transcranial direct current stimulation: The possibility of near and far transfer.
Neuropsychologia 2016; 93(Pt A):85-96N

Abstract

Although working memory (WM) training programs consistently result in improvement on the trained task, benefit is typically short-lived and extends only to tasks very similar to the trained task (i.e., near transfer). It is possible that pairing repeated performance of a WM task with brain stimulation encourages plasticity in brain networks involved in WM task performance, thereby improving the training benefit. In the current study, transcranial direct current stimulation (tDCS) was paired with performance of a WM task (n-back). In Experiment 1, participants performed a spatial location-monitoring n-back during stimulation, while Experiment 2 used a verbal identity-monitoring n-back. In each experiment, participants received either active (2.0mA) or sham (0.1mA) stimulation with the anode placed over either the right or the left dorsolateral prefrontal cortex (DLPFC) and the cathode placed extracephalically. In Experiment 1, only participants receiving active stimulation with the anode placed over the right DLPFC showed marginal improvement on the trained spatial n-back, which did not extend to a near transfer (verbal n-back) or far transfer task (a matrix-reasoning task designed to measure fluid intelligence). In Experiment 2, both left and right anode placements led to improvement, and right DLPFC stimulation resulted in numerical (though not sham-adjusted) improvement on the near transfer (spatial n-back) and far transfer (fluid intelligence) task. Results suggest that WM training paired with brain stimulation may result in cognitive enhancement that transfers to performance on other tasks, depending on the combination of training task and tDCS parameters used.

Authors+Show Affiliations

Sandia National Laboratories, USA; Department of Psychology, The University of New Mexico, Albuquerque, NM, USA; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, USA. Electronic address: mctrumb@sandia.gov.Sandia National Laboratories, USA.Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.Department of Psychology, The University of New Mexico, Albuquerque, NM, USA; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, USA.Department of Psychology, The University of New Mexico, Albuquerque, NM, USA; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, USA.Department of Psychology, The University of New Mexico, Albuquerque, NM, USA; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, USA.Department of Psychology, The University of New Mexico, Albuquerque, NM, USA; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27756695

Citation

Trumbo, Michael C., et al. "Enhanced Working Memory Performance Via Transcranial Direct Current Stimulation: the Possibility of Near and Far Transfer." Neuropsychologia, vol. 93, no. Pt A, 2016, pp. 85-96.
Trumbo MC, Matzen LE, Coffman BA, et al. Enhanced working memory performance via transcranial direct current stimulation: The possibility of near and far transfer. Neuropsychologia. 2016;93(Pt A):85-96.
Trumbo, M. C., Matzen, L. E., Coffman, B. A., Hunter, M. A., Jones, A. P., Robinson, C. S. H., & Clark, V. P. (2016). Enhanced working memory performance via transcranial direct current stimulation: The possibility of near and far transfer. Neuropsychologia, 93(Pt A), pp. 85-96. doi:10.1016/j.neuropsychologia.2016.10.011.
Trumbo MC, et al. Enhanced Working Memory Performance Via Transcranial Direct Current Stimulation: the Possibility of Near and Far Transfer. Neuropsychologia. 2016;93(Pt A):85-96. PubMed PMID: 27756695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced working memory performance via transcranial direct current stimulation: The possibility of near and far transfer. AU - Trumbo,Michael C, AU - Matzen,Laura E, AU - Coffman,Brian A, AU - Hunter,Michael A, AU - Jones,Aaron P, AU - Robinson,Charles S H, AU - Clark,Vincent P, Y1 - 2016/10/15/ PY - 2016/06/22/received PY - 2016/09/16/revised PY - 2016/10/14/accepted PY - 2016/10/30/pubmed PY - 2017/5/10/medline PY - 2016/11/7/entrez KW - Brain stimulation KW - Fluid intelligence KW - Transcranial direct current stimulation KW - Transfer KW - Working memory SP - 85 EP - 96 JF - Neuropsychologia JO - Neuropsychologia VL - 93 IS - Pt A N2 - Although working memory (WM) training programs consistently result in improvement on the trained task, benefit is typically short-lived and extends only to tasks very similar to the trained task (i.e., near transfer). It is possible that pairing repeated performance of a WM task with brain stimulation encourages plasticity in brain networks involved in WM task performance, thereby improving the training benefit. In the current study, transcranial direct current stimulation (tDCS) was paired with performance of a WM task (n-back). In Experiment 1, participants performed a spatial location-monitoring n-back during stimulation, while Experiment 2 used a verbal identity-monitoring n-back. In each experiment, participants received either active (2.0mA) or sham (0.1mA) stimulation with the anode placed over either the right or the left dorsolateral prefrontal cortex (DLPFC) and the cathode placed extracephalically. In Experiment 1, only participants receiving active stimulation with the anode placed over the right DLPFC showed marginal improvement on the trained spatial n-back, which did not extend to a near transfer (verbal n-back) or far transfer task (a matrix-reasoning task designed to measure fluid intelligence). In Experiment 2, both left and right anode placements led to improvement, and right DLPFC stimulation resulted in numerical (though not sham-adjusted) improvement on the near transfer (spatial n-back) and far transfer (fluid intelligence) task. Results suggest that WM training paired with brain stimulation may result in cognitive enhancement that transfers to performance on other tasks, depending on the combination of training task and tDCS parameters used. SN - 1873-3514 UR - https://www.unboundmedicine.com/medline/citation/27756695/Enhanced_working_memory_performance_via_transcranial_direct_current_stimulation:_The_possibility_of_near_and_far_transfer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3932(16)30385-2 DB - PRIME DP - Unbound Medicine ER -