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The association between dietary vitamin A intake and pancreatic cancer risk: a meta-analysis of 11 studies.

Abstract

Whether dietary vitamin A intake could reduce pancreatic cancer risk is still conflicting. We therefore conducted a meta-analysis to summarize the evidence from epidemiological studies. We searched the databases of PubMed and Web of Knowledge up to July 2016. Random model was used to combine study-specific relative risks (RR) and 95% confidence interval (CI). Publication bias was assessed by Egger regression asymmetry test and Begg's funnel plot. Eleven studies (10 case-control studies and 1 cohort study) involving 2705 pancreatic cancer cases were included in the present study. The RR (95% CI) of pancreatic cancer for highest category of vitamin A intake compared with lowest category was 0.839 (95% CI=0.712-0.988) with low heterogeneity detected (I2=17.8%, Pheterogeneity=0.274). The relationships were also significant for studies designed by case-control [RR=0.808, 95% CI=0.690-0.947], as well as in European population [RR=0.821, 95% CI=0.693-0.972]. No evidence of publication bias was found. This meta-analysis demonstrated that dietary vitamin A intake might inversely associated with the risk of pancreatic cancer.

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  • Authors+Show Affiliations

    ,

    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

    ,

    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

    ,

    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

    ,

    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

    ,

    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

    ,

    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

    ,

    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China shuguang0888@sohu.com.

    Source

    Bioscience reports 36:6 2016 12 pg

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Case-Control Studies
    Cross-Sectional Studies
    Diet
    Female
    Humans
    Male
    Middle Aged
    Pancreatic Neoplasms
    Prospective Studies
    Risk
    Vitamin A

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    27756825

    Citation

    Zhang, Tao, et al. "The Association Between Dietary Vitamin a Intake and Pancreatic Cancer Risk: a Meta-analysis of 11 Studies." Bioscience Reports, vol. 36, no. 6, 2016.
    Zhang T, Chen H, Qin S, et al. The association between dietary vitamin A intake and pancreatic cancer risk: a meta-analysis of 11 studies. Biosci Rep. 2016;36(6).
    Zhang, T., Chen, H., Qin, S., Wang, M., Wang, X., Zhang, X., ... Zhang, S. (2016). The association between dietary vitamin A intake and pancreatic cancer risk: a meta-analysis of 11 studies. Bioscience Reports, 36(6), doi:10.1042/BSR20160341.
    Zhang T, et al. The Association Between Dietary Vitamin a Intake and Pancreatic Cancer Risk: a Meta-analysis of 11 Studies. Biosci Rep. 2016;36(6) PubMed PMID: 27756825.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The association between dietary vitamin A intake and pancreatic cancer risk: a meta-analysis of 11 studies. AU - Zhang,Tao, AU - Chen,Hongqiang, AU - Qin,Shiyong, AU - Wang,Minghai, AU - Wang,Xianming, AU - Zhang,Xin, AU - Liu,Fei, AU - Zhang,Shuguang, Y1 - 2016/11/22/ PY - 2016/08/18/received PY - 2016/09/13/revised PY - 2016/10/18/accepted PY - 2016/10/21/pubmed PY - 2017/12/6/medline PY - 2016/10/21/entrez KW - meta-analysis KW - pancreatic cancer KW - vitamin A JF - Bioscience reports JO - Biosci. Rep. VL - 36 IS - 6 N2 - Whether dietary vitamin A intake could reduce pancreatic cancer risk is still conflicting. We therefore conducted a meta-analysis to summarize the evidence from epidemiological studies. We searched the databases of PubMed and Web of Knowledge up to July 2016. Random model was used to combine study-specific relative risks (RR) and 95% confidence interval (CI). Publication bias was assessed by Egger regression asymmetry test and Begg's funnel plot. Eleven studies (10 case-control studies and 1 cohort study) involving 2705 pancreatic cancer cases were included in the present study. The RR (95% CI) of pancreatic cancer for highest category of vitamin A intake compared with lowest category was 0.839 (95% CI=0.712-0.988) with low heterogeneity detected (I2=17.8%, Pheterogeneity=0.274). The relationships were also significant for studies designed by case-control [RR=0.808, 95% CI=0.690-0.947], as well as in European population [RR=0.821, 95% CI=0.693-0.972]. No evidence of publication bias was found. This meta-analysis demonstrated that dietary vitamin A intake might inversely associated with the risk of pancreatic cancer. SN - 1573-4935 UR - https://www.unboundmedicine.com/medline/citation/27756825/The_association_between_dietary_vitamin_A_intake_and_pancreatic_cancer_risk:_a_meta_analysis_of_11_studies_ L2 - http://www.bioscirep.org/cgi/pmidlookup?view=long&pmid=27756825 DB - PRIME DP - Unbound Medicine ER -