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Congenital Abnormalities: Consequence of Maternal Zika Virus Infection: A Narrative Review.
Infect Disord Drug Targets. 2017; 17(1):3-13.ID

Abstract

BACKGROUND

Zika virus (ZIKV) is a deadly flavivirus that has spread from Africa to Asia and European countries. The virus is associated with other viruses in the same genus or family, transmitted by the same mosquito species with known history of fatality. A sudden increase in the rate of infection from ZIKV has made it a global health concern, which necessitates close symptom monitoring, enhancing treatment options, and vaccine production.

OBJECTIVES

This paper reviewed current reports on birth defects associated with ZIKV, mode of transmission, body fluids containing the virus, diagnosis, possible preventive measures or treatments, and vaccine development.

METHODS

Google scholar was used as the major search engine for research and review articles, up to July, 2016. Search terms such as "ZIKV", "ZIKV infection", "ZIKV serotypes", "treatment of ZIKV infection", "co-infection with zika virus", "flavivirus", "microcephaly and zika", "birth defects and Zika", as well as "ZIKV vaccine" were used.

RESULTS

ZIKV has been detected in several body fluids such as saliva, semen, blood, and amniotic fluid. This reveals the possibility of sexual and mother to child transmission. The ability of the virus to cross the placental barrier and the blood brain barrier (BBB) has been associated with birth defects such as microcephaly, ocular defects, and Guillian Barre syndrome (GBS). Preventive measures can reduce the spread and risk of the infection. Available treatments only target symptoms while vaccines are still under development.

CONCLUSION

Birth defects are associated with ZIKV infection in pregnant women; hence the need for development of standard treatments, employment of strict preventive measures and development of effective vaccines.

Authors+Show Affiliations

International Campus, Tehran University of Medical Sciences (IC-TUMS), Tehran. Iran.Toxicology and Diseases Group, Pharmaceutocal Sciences Research Center, Tehran University of Medical Sciences, Tehran. Iran.Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran. Iran.Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran. Iran.Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411. Iran.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27758685

Citation

Hassan, Fatima I., et al. "Congenital Abnormalities: Consequence of Maternal Zika Virus Infection: a Narrative Review." Infectious Disorders Drug Targets, vol. 17, no. 1, 2017, pp. 3-13.
Hassan FI, Niaz K, Maqbool F, et al. Congenital Abnormalities: Consequence of Maternal Zika Virus Infection: A Narrative Review. Infect Disord Drug Targets. 2017;17(1):3-13.
Hassan, F. I., Niaz, K., Maqbool, F., Khan, F., & Abdollahi, M. (2017). Congenital Abnormalities: Consequence of Maternal Zika Virus Infection: A Narrative Review. Infectious Disorders Drug Targets, 17(1), 3-13. https://doi.org/10.2174/1871526516666161018104916
Hassan FI, et al. Congenital Abnormalities: Consequence of Maternal Zika Virus Infection: a Narrative Review. Infect Disord Drug Targets. 2017;17(1):3-13. PubMed PMID: 27758685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Congenital Abnormalities: Consequence of Maternal Zika Virus Infection: A Narrative Review. AU - Hassan,Fatima I, AU - Niaz,Kamal, AU - Maqbool,Faheem, AU - Khan,Fazlullah, AU - Abdollahi,Mohammad, PY - 2016/09/21/received PY - 2016/10/10/revised PY - 2016/10/10/accepted PY - 2016/10/21/pubmed PY - 2018/6/7/medline PY - 2016/10/21/entrez KW - Birth defects KW - ZIKV KW - infection KW - microcephaly KW - review KW - vaccine SP - 3 EP - 13 JF - Infectious disorders drug targets JO - Infect Disord Drug Targets VL - 17 IS - 1 N2 - BACKGROUND: Zika virus (ZIKV) is a deadly flavivirus that has spread from Africa to Asia and European countries. The virus is associated with other viruses in the same genus or family, transmitted by the same mosquito species with known history of fatality. A sudden increase in the rate of infection from ZIKV has made it a global health concern, which necessitates close symptom monitoring, enhancing treatment options, and vaccine production. OBJECTIVES: This paper reviewed current reports on birth defects associated with ZIKV, mode of transmission, body fluids containing the virus, diagnosis, possible preventive measures or treatments, and vaccine development. METHODS: Google scholar was used as the major search engine for research and review articles, up to July, 2016. Search terms such as "ZIKV", "ZIKV infection", "ZIKV serotypes", "treatment of ZIKV infection", "co-infection with zika virus", "flavivirus", "microcephaly and zika", "birth defects and Zika", as well as "ZIKV vaccine" were used. RESULTS: ZIKV has been detected in several body fluids such as saliva, semen, blood, and amniotic fluid. This reveals the possibility of sexual and mother to child transmission. The ability of the virus to cross the placental barrier and the blood brain barrier (BBB) has been associated with birth defects such as microcephaly, ocular defects, and Guillian Barre syndrome (GBS). Preventive measures can reduce the spread and risk of the infection. Available treatments only target symptoms while vaccines are still under development. CONCLUSION: Birth defects are associated with ZIKV infection in pregnant women; hence the need for development of standard treatments, employment of strict preventive measures and development of effective vaccines. SN - 2212-3989 UR - https://www.unboundmedicine.com/medline/citation/27758685/Congenital_Abnormalities:_Consequence_of_Maternal_Zika_Virus_Infection:_A_Narrative_Review_ L2 - http://www.eurekaselect.com/146415/article DB - PRIME DP - Unbound Medicine ER -