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A case-control study of epidemiological factors associated with leptospirosis in South Gujarat region.
J Postgrad Med. 2016 Oct-Dec; 62(4):223-227.JP

Abstract

BACKGROUND

The current study was planned to identify the epidemiological factors associated with leptospirosis in South Gujarat region using neighborhood controls.

METHODS

A total of 100 cases of leptospirosis occurred in South Gujarat region during the year 2012 were selected using simple random sampling. Three neighbors of the selected cases formed the controls (n = 300). A pretested structured questionnaire was used for data collection and data were analyzed using Epi Info 2007.

RESULTS

There was significant association of illiteracy (odds ratio [OR] =1.82, 95% confidence interval [CI] =1.14-2.89), working in waterlogged fields during the reference season (OR = 4.6, 95% CI = 1.6-17.9), swimming/bathing in canals, open air defecation practices, storage of cow dung in or surrounding house, residence in the house made up of cow dung walls, households with access of food to rodents, injuries over hands/foot during the endemic season (OR = 3, 95% CI = 1.8-4.8), and history of skin disease during the endemic season (OR = 4.2, 95% CI = 2-8.5), with leptospirosis. Only 10% of individuals had gumboots for protection. A total of 83 (83%) cases and 240 (80%) controls had taken oral doxycycline chemoprophylaxis (P > 0.05). Cases had taken chemoprophylaxis for a median 4 weeks (range: 1-8) while controls had taken the same for median 8 weeks (range = 1-8) (P < 0.002).

CONCLUSIONS

Although the commonly established factors appear to be associated with leptospirosis, the role of host factors seems to play a more important role in determining susceptibility to leptospirosis in exposed individuals.

Authors+Show Affiliations

Department of Community Medicine, Surat Municipal Institute of Medical Education and Research, Surat, Gujarat, India.Department of Community Medicine, Surat Municipal Institute of Medical Education and Research, Surat, Gujarat, India.Department of Community Medicine, Surat Municipal Institute of Medical Education and Research, Surat, Gujarat, India.Department of Community Medicine, Surat Municipal Institute of Medical Education and Research, Surat, Gujarat, India.Department of Community Medicine, Surat Municipal Institute of Medical Education and Research, Surat, Gujarat, India.Department of Community Medicine, Surat Municipal Institute of Medical Education and Research, Surat, Gujarat, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27763478

Citation

Desai, K T., et al. "A Case-control Study of Epidemiological Factors Associated With Leptospirosis in South Gujarat Region." Journal of Postgraduate Medicine, vol. 62, no. 4, 2016, pp. 223-227.
Desai KT, Patel F, Patel PB, et al. A case-control study of epidemiological factors associated with leptospirosis in South Gujarat region. J Postgrad Med. 2016;62(4):223-227.
Desai, K. T., Patel, F., Patel, P. B., Nayak, S., Patel, N. B., & Bansal, R. K. (2016). A case-control study of epidemiological factors associated with leptospirosis in South Gujarat region. Journal of Postgraduate Medicine, 62(4), 223-227. https://doi.org/10.4103/0022-3859.188551
Desai KT, et al. A Case-control Study of Epidemiological Factors Associated With Leptospirosis in South Gujarat Region. J Postgrad Med. 2016 Oct-Dec;62(4):223-227. PubMed PMID: 27763478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case-control study of epidemiological factors associated with leptospirosis in South Gujarat region. AU - Desai,K T, AU - Patel,F, AU - Patel,P B, AU - Nayak,S, AU - Patel,N B, AU - Bansal,R K, PY - 2016/10/21/pubmed PY - 2017/1/4/medline PY - 2016/10/21/entrez SP - 223 EP - 227 JF - Journal of postgraduate medicine JO - J Postgrad Med VL - 62 IS - 4 N2 - BACKGROUND: The current study was planned to identify the epidemiological factors associated with leptospirosis in South Gujarat region using neighborhood controls. METHODS: A total of 100 cases of leptospirosis occurred in South Gujarat region during the year 2012 were selected using simple random sampling. Three neighbors of the selected cases formed the controls (n = 300). A pretested structured questionnaire was used for data collection and data were analyzed using Epi Info 2007. RESULTS: There was significant association of illiteracy (odds ratio [OR] =1.82, 95% confidence interval [CI] =1.14-2.89), working in waterlogged fields during the reference season (OR = 4.6, 95% CI = 1.6-17.9), swimming/bathing in canals, open air defecation practices, storage of cow dung in or surrounding house, residence in the house made up of cow dung walls, households with access of food to rodents, injuries over hands/foot during the endemic season (OR = 3, 95% CI = 1.8-4.8), and history of skin disease during the endemic season (OR = 4.2, 95% CI = 2-8.5), with leptospirosis. Only 10% of individuals had gumboots for protection. A total of 83 (83%) cases and 240 (80%) controls had taken oral doxycycline chemoprophylaxis (P > 0.05). Cases had taken chemoprophylaxis for a median 4 weeks (range: 1-8) while controls had taken the same for median 8 weeks (range = 1-8) (P < 0.002). CONCLUSIONS: Although the commonly established factors appear to be associated with leptospirosis, the role of host factors seems to play a more important role in determining susceptibility to leptospirosis in exposed individuals. SN - 0972-2823 UR - https://www.unboundmedicine.com/medline/citation/27763478/A_case_control_study_of_epidemiological_factors_associated_with_leptospirosis_in_South_Gujarat_region_ L2 - http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2016;volume=62;issue=4;spage=223;epage=227;aulast=Desai DB - PRIME DP - Unbound Medicine ER -