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Serial studies on the affinity and heterogeneity of human autoantibodies to thyroglobulin.
Clin Exp Immunol. 1989 Aug; 77(2):191-5.CE

Abstract

The functional affinity and heterogeneity of autoantibodies to thyroglobulin (Tg) were measured by an IgG subclass-specific solid-phase competition ELISA in patients with autoimmune thyroid disease. High-affinity IgG1 and IgG4 antibodies formed the major anti-Tg response. Both titre and affinity of IgG3 and IgG2 anti-Tg were generally low but in some Hashimoto's disease patients high-affinity IgG2 anti-Tg were found and IgG2 anti-Tg, unlike those of other subclasses, showed very restricted heterogeneity. The affinity of IgG4 anti-Tg was similar in patients with thyroid disease and their clinically euthyroid (normal) relatives. In contrast, a progressive increase in IgG1 anti-Tg affinity was seen in clinically euthyroid individuals compared with their relatives with thyroid disease and high titred Hashimoto's disease patients, suggesting that either rising titres of high affinity IgG1 anti-Tg or affinity maturation of IgG1 anti-Tg may be indicative of impending hypothyroidism.

Authors+Show Affiliations

Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2776357

Citation

Devey, M E., et al. "Serial Studies On the Affinity and Heterogeneity of Human Autoantibodies to Thyroglobulin." Clinical and Experimental Immunology, vol. 77, no. 2, 1989, pp. 191-5.
Devey ME, Bleasdale-Barr KM, McLachlan SM, et al. Serial studies on the affinity and heterogeneity of human autoantibodies to thyroglobulin. Clin Exp Immunol. 1989;77(2):191-5.
Devey, M. E., Bleasdale-Barr, K. M., McLachlan, S. M., Bradbury, J., Clark, F., & Young, E. T. (1989). Serial studies on the affinity and heterogeneity of human autoantibodies to thyroglobulin. Clinical and Experimental Immunology, 77(2), 191-5.
Devey ME, et al. Serial Studies On the Affinity and Heterogeneity of Human Autoantibodies to Thyroglobulin. Clin Exp Immunol. 1989;77(2):191-5. PubMed PMID: 2776357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serial studies on the affinity and heterogeneity of human autoantibodies to thyroglobulin. AU - Devey,M E, AU - Bleasdale-Barr,K M, AU - McLachlan,S M, AU - Bradbury,J, AU - Clark,F, AU - Young,E T, PY - 1989/8/1/pubmed PY - 1989/8/1/medline PY - 1989/8/1/entrez SP - 191 EP - 5 JF - Clinical and experimental immunology JO - Clin. Exp. Immunol. VL - 77 IS - 2 N2 - The functional affinity and heterogeneity of autoantibodies to thyroglobulin (Tg) were measured by an IgG subclass-specific solid-phase competition ELISA in patients with autoimmune thyroid disease. High-affinity IgG1 and IgG4 antibodies formed the major anti-Tg response. Both titre and affinity of IgG3 and IgG2 anti-Tg were generally low but in some Hashimoto's disease patients high-affinity IgG2 anti-Tg were found and IgG2 anti-Tg, unlike those of other subclasses, showed very restricted heterogeneity. The affinity of IgG4 anti-Tg was similar in patients with thyroid disease and their clinically euthyroid (normal) relatives. In contrast, a progressive increase in IgG1 anti-Tg affinity was seen in clinically euthyroid individuals compared with their relatives with thyroid disease and high titred Hashimoto's disease patients, suggesting that either rising titres of high affinity IgG1 anti-Tg or affinity maturation of IgG1 anti-Tg may be indicative of impending hypothyroidism. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/2776357/Serial_studies_on_the_affinity_and_heterogeneity_of_human_autoantibodies_to_thyroglobulin_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/2776357/ DB - PRIME DP - Unbound Medicine ER -