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Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations.
J Nutr Biochem 2016; 38:154-161JN

Abstract

Blackcurrants are rich in polyphenolic glycosides called anthocyanins, which may inhibit postprandial glycemia. The aim was to determine the dose-dependent effects of blackcurrant extract on postprandial glycemia. Men and postmenopausal women (14M, 9W, mean age 46 years, S.D.=14) were enrolled into a randomized, double-blind, crossover trial. Low sugar fruit drinks containing blackcurrant extract providing 150-mg (L-BE), 300-mg (M-BE) and 600-mg (H-BE) total anthocyanins or no blackcurrant extract (CON) were administered immediately before a high-carbohydrate meal. Plasma glucose, insulin and incretins (GIP and GLP-1) were measured 0-120min, and plasma 8-isoprostane F2α, together with arterial stiffness by digital volume pulse (DVP) was measured at 0 and 120min. Early plasma glucose response was significantly reduced following H-BE (n=22), relative to CON, with a mean difference (95% CI) in area over baseline (AOB) 0-30min of -0.34mmol/l.h (-0.56, -0.11, P<.005); there were no differences between the intermediate doses and placebo. Plasma insulin concentrations (AOB 0-30min) were similarly reduced. Plasma GIP concentrations (AOB 0-120min) were significantly reduced following H-BE, with a mean difference of -46.6ng/l.h (-66.7, -26.5, P<.0001) compared to CON. Plasma GLP-1 concentrations were reduced following H-BE at 90min. There were no effects on 8-isoprostane F2α or vascular function. Consumption of blackcurrant extract in amounts roughly equivalent to 100-g blackcurrants reduced postprandial glycemia, insulinemia and incretin secretion, which suggests that inclusion of blackcurrant polyphenols in foods may provide cardio-metabolic health benefits. This trial was registered at clinicaltrials.gov as NCT01706653.

Authors+Show Affiliations

Diabetes & Nutritional Sciences Division, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.Diabetes & Nutritional Sciences Division, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.GlaxoSmithKline Services Unlimited, GSK House, 980 Great West Road, Middlesex, TW8 9GS, UK.Suntory Beverage and Food Europe Ltd, 2 Longwalk Road, Stockley Park, Uxbridge UB11 1BA, UK.Suntory Beverage and Food Europe Ltd, 2 Longwalk Road, Stockley Park, Uxbridge UB11 1BA, UK.Diabetes & Nutritional Sciences Division, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK. Electronic address: wendy.hall@kcl.ac.uk.

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

27764725

Citation

Castro-Acosta, Monica L., et al. "Drinks Containing Anthocyanin-rich Blackcurrant Extract Decrease Postprandial Blood Glucose, Insulin and Incretin Concentrations." The Journal of Nutritional Biochemistry, vol. 38, 2016, pp. 154-161.
Castro-Acosta ML, Smith L, Miller RJ, et al. Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations. J Nutr Biochem. 2016;38:154-161.
Castro-Acosta, M. L., Smith, L., Miller, R. J., McCarthy, D. I., Farrimond, J. A., & Hall, W. L. (2016). Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations. The Journal of Nutritional Biochemistry, 38, pp. 154-161. doi:10.1016/j.jnutbio.2016.09.002.
Castro-Acosta ML, et al. Drinks Containing Anthocyanin-rich Blackcurrant Extract Decrease Postprandial Blood Glucose, Insulin and Incretin Concentrations. J Nutr Biochem. 2016;38:154-161. PubMed PMID: 27764725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations. AU - Castro-Acosta,Monica L, AU - Smith,Leanne, AU - Miller,Rosalind J, AU - McCarthy,Danielle I, AU - Farrimond,Jonathan A, AU - Hall,Wendy L, Y1 - 2016/09/14/ PY - 2016/05/25/received PY - 2016/09/09/revised PY - 2016/09/12/accepted PY - 2016/10/21/pubmed PY - 2017/11/29/medline PY - 2016/10/21/entrez KW - Anthocyanins KW - Berries KW - Incretins KW - Insulin KW - Polyphenols KW - Postprandial glycemia KW - Randomized controlled trial SP - 154 EP - 161 JF - The Journal of nutritional biochemistry JO - J. Nutr. Biochem. VL - 38 N2 - Blackcurrants are rich in polyphenolic glycosides called anthocyanins, which may inhibit postprandial glycemia. The aim was to determine the dose-dependent effects of blackcurrant extract on postprandial glycemia. Men and postmenopausal women (14M, 9W, mean age 46 years, S.D.=14) were enrolled into a randomized, double-blind, crossover trial. Low sugar fruit drinks containing blackcurrant extract providing 150-mg (L-BE), 300-mg (M-BE) and 600-mg (H-BE) total anthocyanins or no blackcurrant extract (CON) were administered immediately before a high-carbohydrate meal. Plasma glucose, insulin and incretins (GIP and GLP-1) were measured 0-120min, and plasma 8-isoprostane F2α, together with arterial stiffness by digital volume pulse (DVP) was measured at 0 and 120min. Early plasma glucose response was significantly reduced following H-BE (n=22), relative to CON, with a mean difference (95% CI) in area over baseline (AOB) 0-30min of -0.34mmol/l.h (-0.56, -0.11, P<.005); there were no differences between the intermediate doses and placebo. Plasma insulin concentrations (AOB 0-30min) were similarly reduced. Plasma GIP concentrations (AOB 0-120min) were significantly reduced following H-BE, with a mean difference of -46.6ng/l.h (-66.7, -26.5, P<.0001) compared to CON. Plasma GLP-1 concentrations were reduced following H-BE at 90min. There were no effects on 8-isoprostane F2α or vascular function. Consumption of blackcurrant extract in amounts roughly equivalent to 100-g blackcurrants reduced postprandial glycemia, insulinemia and incretin secretion, which suggests that inclusion of blackcurrant polyphenols in foods may provide cardio-metabolic health benefits. This trial was registered at clinicaltrials.gov as NCT01706653. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/27764725/Drinks_containing_anthocyanin_rich_blackcurrant_extract_decrease_postprandial_blood_glucose_insulin_and_incretin_concentrations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(16)30106-1 DB - PRIME DP - Unbound Medicine ER -