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Hyperin inhibits nuclear factor kappa B and activates nuclear factor E2-related factor-2 signaling pathways in cisplatin-induced acute kidney injury in mice.
Int Immunopharmacol. 2016 Nov; 40:517-523.II

Abstract

Hyperin, a flavonoid compound found in Ericaceae, Guttiferae, and Celastraceae, has been reported to have anti-inflammatory effects. In the present study, we investigated the effects of hyperin on cisplatin-induced acute kidney injury (AKI) in mice. The renal tissue damage induced by cisplatin was detected by H&E staining. Blood urea nitrogen (BUN), creatinine, reactive oxygen species (ROS), and malondialdehyde (MDA) were also detected. Further, the effects of hyperin on cisplatin-induced TNF-α, IL-1β and IL-6 were detected by ELISA. In addition, the phosphorylation of nuclear factor kappa B (NF-κB) and the expression of nuclear factor E2-related factor-2 (Nrf2) and HO-1 were detected by western blot analysis. The results showed that hyperin attenuated histological changes of kidney induced by cisplatin. The levels of BUN, creatinine, ROS, MDA, TNF-α, IL-1β and IL-6 induced by cisplatin were also inhibited by hyperin. Cisplatin-induced NF-κB activation was inhibited by hyperin. Additionally, hyperin was found to up regulate the expression of Nrf2 and HO-1. In conclusion, the results suggest that hyperin protects against cisplatin-induced AKI by inhibiting inflammatory and oxidant response.

Authors+Show Affiliations

Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, ROC; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, ROC; Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan, ROC.Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan, ROC.Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, ROC.Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, ROC.Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, ROC.School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, ROC. Electronic address: yangshchunjj@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27764742

Citation

Chao, Chia-Sheng, et al. "Hyperin Inhibits Nuclear Factor Kappa B and Activates Nuclear Factor E2-related Factor-2 Signaling Pathways in Cisplatin-induced Acute Kidney Injury in Mice." International Immunopharmacology, vol. 40, 2016, pp. 517-523.
Chao CS, Tsai CS, Chang YP, et al. Hyperin inhibits nuclear factor kappa B and activates nuclear factor E2-related factor-2 signaling pathways in cisplatin-induced acute kidney injury in mice. Int Immunopharmacol. 2016;40:517-523.
Chao, C. S., Tsai, C. S., Chang, Y. P., Chen, J. M., Chin, H. K., & Yang, S. C. (2016). Hyperin inhibits nuclear factor kappa B and activates nuclear factor E2-related factor-2 signaling pathways in cisplatin-induced acute kidney injury in mice. International Immunopharmacology, 40, 517-523. https://doi.org/10.1016/j.intimp.2016.09.020
Chao CS, et al. Hyperin Inhibits Nuclear Factor Kappa B and Activates Nuclear Factor E2-related Factor-2 Signaling Pathways in Cisplatin-induced Acute Kidney Injury in Mice. Int Immunopharmacol. 2016;40:517-523. PubMed PMID: 27764742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperin inhibits nuclear factor kappa B and activates nuclear factor E2-related factor-2 signaling pathways in cisplatin-induced acute kidney injury in mice. AU - Chao,Chia-Sheng, AU - Tsai,Chien-Sung, AU - Chang,Yee-Phoung, AU - Chen,Jian-Ming, AU - Chin,Hsien-Kuo, AU - Yang,Shyh-Chyun, Y1 - 2016/10/17/ PY - 2016/07/01/received PY - 2016/09/19/revised PY - 2016/09/22/accepted PY - 2016/11/7/entrez PY - 2016/10/21/pubmed PY - 2017/4/18/medline KW - Cisplatin KW - Hyperin KW - Kidney injury KW - Nrf2 SP - 517 EP - 523 JF - International immunopharmacology JO - Int Immunopharmacol VL - 40 N2 - Hyperin, a flavonoid compound found in Ericaceae, Guttiferae, and Celastraceae, has been reported to have anti-inflammatory effects. In the present study, we investigated the effects of hyperin on cisplatin-induced acute kidney injury (AKI) in mice. The renal tissue damage induced by cisplatin was detected by H&E staining. Blood urea nitrogen (BUN), creatinine, reactive oxygen species (ROS), and malondialdehyde (MDA) were also detected. Further, the effects of hyperin on cisplatin-induced TNF-α, IL-1β and IL-6 were detected by ELISA. In addition, the phosphorylation of nuclear factor kappa B (NF-κB) and the expression of nuclear factor E2-related factor-2 (Nrf2) and HO-1 were detected by western blot analysis. The results showed that hyperin attenuated histological changes of kidney induced by cisplatin. The levels of BUN, creatinine, ROS, MDA, TNF-α, IL-1β and IL-6 induced by cisplatin were also inhibited by hyperin. Cisplatin-induced NF-κB activation was inhibited by hyperin. Additionally, hyperin was found to up regulate the expression of Nrf2 and HO-1. In conclusion, the results suggest that hyperin protects against cisplatin-induced AKI by inhibiting inflammatory and oxidant response. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/27764742/Hyperin_inhibits_nuclear_factor_kappa_B_and_activates_nuclear_factor_E2_related_factor_2_signaling_pathways_in_cisplatin_induced_acute_kidney_injury_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(16)30394-0 DB - PRIME DP - Unbound Medicine ER -