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Prevalence of restless legs syndrome in chronic kidney disease: a systematic review and meta-analysis of observational studies.
Ren Fail. 2016 Oct; 38(9):1335-1346.RF

Abstract

INTRODUCTION

Nowadays prevalence of restless legs syndrome (RLS) in chronic kidney disease (CKD) patients was reported in many studies, while the results varied. The aim of our study was to investigate the prevalence of RLS in this population, considering different data collecting measures and diagnostic criteria.

METHODS

MEDLINE, Embase, PsycINFO, and Scopus databases were searched for relevant studies. We limited the analyses to studies using clinical interview or questionnaire for diagnosis. Univariate meta-regression analysis was preformed to assess the effects of the disease-related covariates on prevalence estimates. Comprehensive Meta-Analysis 2.0 was used to perform the meta-analysis.

RESULTS

Fifty-one studies were included in the analysis. Prevalence of RLS was varied by renal function and diagnostic methods. Overall prevalence in CKD populations was 24.2% (95%CI, 20.1-28.7). Pooled prevalence of RLS was higher in patients diagnosed by questionnaire than by clinical interview [26.2% (95%CI, 17.9-36.5) vs. 23.6% (95%CI, 19.6-28.1)]. When grouped by CKD setting, the prevalence was 28.4% (95%CI, 24.6-32.6) in dialysis patients, followed by early stages patients [9.9% (95%CI, 5.4-17.5)], and kidney transplant recipients [6.7% (95%CI, 5.6-7.8)].

CONCLUSIONS

Our meta-analysis suggested that more than one-quarter of CKD sufferers, especially those who were on dialysis, were plagued by RLS. Higher sensitivity of diagnostic criteria in interview may be valuable for timely treatment.

Authors+Show Affiliations

Lin Z
a Department of Nephrology , The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health , Guangzhou , China.
Zhao C
a Department of Nephrology , The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health , Guangzhou , China.
Luo Q
a Department of Nephrology , The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health , Guangzhou , China.
Xia X
a Department of Nephrology , The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health , Guangzhou , China.
Yu X
a Department of Nephrology , The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health , Guangzhou , China.
Huang F
a Department of Nephrology , The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health , Guangzhou , China.

MeSH

Global HealthHumansObservational Studies as TopicPrevalenceRenal Insufficiency, ChronicRestless Legs SyndromeRisk FactorsSurveys and Questionnaires

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27765002

Citation

Lin, Zhenchuan, et al. "Prevalence of Restless Legs Syndrome in Chronic Kidney Disease: a Systematic Review and Meta-analysis of Observational Studies." Renal Failure, vol. 38, no. 9, 2016, pp. 1335-1346.
Lin Z, Zhao C, Luo Q, et al. Prevalence of restless legs syndrome in chronic kidney disease: a systematic review and meta-analysis of observational studies. Ren Fail. 2016;38(9):1335-1346.
Lin, Z., Zhao, C., Luo, Q., Xia, X., Yu, X., & Huang, F. (2016). Prevalence of restless legs syndrome in chronic kidney disease: a systematic review and meta-analysis of observational studies. Renal Failure, 38(9), 1335-1346.
Lin Z, et al. Prevalence of Restless Legs Syndrome in Chronic Kidney Disease: a Systematic Review and Meta-analysis of Observational Studies. Ren Fail. 2016;38(9):1335-1346. PubMed PMID: 27765002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of restless legs syndrome in chronic kidney disease: a systematic review and meta-analysis of observational studies. AU - Lin,Zhenchuan, AU - Zhao,Chen, AU - Luo,Qimei, AU - Xia,Xi, AU - Yu,Xueqing, AU - Huang,Fengxian, Y1 - 2016/10/20/ PY - 2016/11/4/pubmed PY - 2017/4/12/medline PY - 2016/11/4/entrez KW - Prevalence KW - chronic kidney disease KW - meta-analysis KW - restless legs syndrome SP - 1335 EP - 1346 JF - Renal failure JO - Ren Fail VL - 38 IS - 9 N2 - INTRODUCTION: Nowadays prevalence of restless legs syndrome (RLS) in chronic kidney disease (CKD) patients was reported in many studies, while the results varied. The aim of our study was to investigate the prevalence of RLS in this population, considering different data collecting measures and diagnostic criteria. METHODS: MEDLINE, Embase, PsycINFO, and Scopus databases were searched for relevant studies. We limited the analyses to studies using clinical interview or questionnaire for diagnosis. Univariate meta-regression analysis was preformed to assess the effects of the disease-related covariates on prevalence estimates. Comprehensive Meta-Analysis 2.0 was used to perform the meta-analysis. RESULTS: Fifty-one studies were included in the analysis. Prevalence of RLS was varied by renal function and diagnostic methods. Overall prevalence in CKD populations was 24.2% (95%CI, 20.1-28.7). Pooled prevalence of RLS was higher in patients diagnosed by questionnaire than by clinical interview [26.2% (95%CI, 17.9-36.5) vs. 23.6% (95%CI, 19.6-28.1)]. When grouped by CKD setting, the prevalence was 28.4% (95%CI, 24.6-32.6) in dialysis patients, followed by early stages patients [9.9% (95%CI, 5.4-17.5)], and kidney transplant recipients [6.7% (95%CI, 5.6-7.8)]. CONCLUSIONS: Our meta-analysis suggested that more than one-quarter of CKD sufferers, especially those who were on dialysis, were plagued by RLS. Higher sensitivity of diagnostic criteria in interview may be valuable for timely treatment. SN - 1525-6049 UR - https://www.unboundmedicine.com/medline/citation/27765002/Prevalence_of_restless_legs_syndrome_in_chronic_kidney_disease:_a_systematic_review_and_meta_analysis_of_observational_studies_ DB - PRIME DP - Unbound Medicine ER -