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Ambulatory Pediatric Surveillance of Hand, Foot and Mouth Disease as Signal of an Outbreak of Coxsackievirus A6 Infections, France, 2014-2015.
Emerg Infect Dis. 2016 11; 22(11):1884-1893.EI

Abstract

The clinical impact of enteroviruses associated with hand, foot and mouth disease (HFMD) is unknown outside Asia, and the prevalence of enterovirus A71 (EV-A71) in particular might be underestimated. To investigate the prevalence of enterovirus serotypes and the clinical presentations associated with HFMD in France, we conducted prospective ambulatory clinic-based surveillance of children during April 2014-March 2015. Throat or buccal swabs were collected from children with HFMD and tested for the enterovirus genome. Physical examinations were recorded on a standardized form. An enterovirus infection was detected in 523 (79.3%) of 659 children tested. Two epidemic waves occurred, dominated by coxsackievirus (CV) A6, which was detected in 53.9% of enterovirus-infected children. CV-A6 was more frequently related to atypical HFMD manifestations (eruptions extended to limbs and face). Early awareness and documentation of HFMD outbreaks can be achieved by syndromic surveillance of HFMD by ambulatory pediatricians and rapid enterovirus testing and genotyping.

Links

Publisher Full Text
ncbi.nlm.nih.gov
dx.doi.org
PMC Free PDF

Authors

Mirand A
No affiliation info available
le Sage FV
No affiliation info available
Pereira B
No affiliation info available
Cohen R
No affiliation info available
Levy C
No affiliation info available
Archimbaud C
No affiliation info available
Peigue-Lafeuille H
No affiliation info available
Bailly JL
No affiliation info available
Henquell C
No affiliation info available

MeSH

AdolescentAge FactorsChildChild, PreschoolDisease OutbreaksEnterovirus A, HumanFemaleFranceHand, Foot and Mouth DiseaseHistory, 21st CenturyHumansInfantInfant, NewbornMaleMolecular TypingPhylogenyPopulation SurveillanceProspective StudiesRNA, ViralSerogroupSymptom Assessment

Pub Type(s)

Historical Article
Journal Article

Language

eng

PubMed ID

27767012

Citation

Mirand, Audrey, et al. "Ambulatory Pediatric Surveillance of Hand, Foot and Mouth Disease as Signal of an Outbreak of Coxsackievirus A6 Infections, France, 2014-2015." Emerging Infectious Diseases, vol. 22, no. 11, 2016, pp. 1884-1893.
Mirand A, le Sage FV, Pereira B, et al. Ambulatory Pediatric Surveillance of Hand, Foot and Mouth Disease as Signal of an Outbreak of Coxsackievirus A6 Infections, France, 2014-2015. Emerging Infect Dis. 2016;22(11):1884-1893.
Mirand, A., le Sage, F. V., Pereira, B., Cohen, R., Levy, C., Archimbaud, C., Peigue-Lafeuille, H., Bailly, J. L., & Henquell, C. (2016). Ambulatory Pediatric Surveillance of Hand, Foot and Mouth Disease as Signal of an Outbreak of Coxsackievirus A6 Infections, France, 2014-2015. Emerging Infectious Diseases, 22(11), 1884-1893. https://doi.org/10.3201/eid2211.160590
Mirand A, et al. Ambulatory Pediatric Surveillance of Hand, Foot and Mouth Disease as Signal of an Outbreak of Coxsackievirus A6 Infections, France, 2014-2015. Emerging Infect Dis. 2016;22(11):1884-1893. PubMed PMID: 27767012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ambulatory Pediatric Surveillance of Hand, Foot and Mouth Disease as Signal of an Outbreak of Coxsackievirus A6 Infections, France, 2014-2015. AU - Mirand,Audrey, AU - le Sage,François Vié, AU - Pereira,Bruno, AU - Cohen,Robert, AU - Levy,Corinne, AU - Archimbaud,Christine, AU - Peigue-Lafeuille,Hélène, AU - Bailly,Jean-Luc, AU - Henquell,Cécile, PY - 2016/10/22/pubmed PY - 2018/1/13/medline PY - 2016/10/22/entrez KW - France KW - ambulatory KW - enterovirus A KW - foot and mouth disease KW - hand KW - human coxsackievirus infections KW - pediatric KW - sentinel surveillance KW - surveillance viruses SP - 1884 EP - 1893 JF - Emerging infectious diseases JO - Emerging Infect. Dis. VL - 22 IS - 11 N2 - The clinical impact of enteroviruses associated with hand, foot and mouth disease (HFMD) is unknown outside Asia, and the prevalence of enterovirus A71 (EV-A71) in particular might be underestimated. To investigate the prevalence of enterovirus serotypes and the clinical presentations associated with HFMD in France, we conducted prospective ambulatory clinic-based surveillance of children during April 2014-March 2015. Throat or buccal swabs were collected from children with HFMD and tested for the enterovirus genome. Physical examinations were recorded on a standardized form. An enterovirus infection was detected in 523 (79.3%) of 659 children tested. Two epidemic waves occurred, dominated by coxsackievirus (CV) A6, which was detected in 53.9% of enterovirus-infected children. CV-A6 was more frequently related to atypical HFMD manifestations (eruptions extended to limbs and face). Early awareness and documentation of HFMD outbreaks can be achieved by syndromic surveillance of HFMD by ambulatory pediatricians and rapid enterovirus testing and genotyping. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/27767012/Ambulatory_Pediatric_Surveillance_of_Hand_Foot_and_Mouth_Disease_as_Signal_of_an_Outbreak_of_Coxsackievirus_A6_Infections_France_2014_2015_ L2 - https://dx.doi.org/10.3201/eid2211.160590 DB - PRIME DP - Unbound Medicine ER -