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Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson's disease: a meta and meta-regression analysis.
Neurol Sci. 2017 Jan; 38(1):163-170.NS

Abstract

Rapid eye movement sleep behavior disorder (RBD) is thought to be one of the most frequent preceding symptoms of Parkinson's disease (PD). However, the prevalence of RBD in PD stated in the published studies is still inconsistent. We conducted a meta and meta-regression analysis in this paper to estimate the pooled prevalence. We searched the electronic databases of PubMed, ScienceDirect, EMBASE and EBSCO up to June 2016 for related articles. STATA 12.0 statistics software was used to calculate the available data from each research. The prevalence of RBD in PD patients in each study was combined to a pooled prevalence with a 95 % confidence interval (CI). Subgroup analysis and meta-regression analysis were performed to search for the causes of the heterogeneity. A total of 28 studies with 6869 PD cases were deemed eligible and included in our meta-analysis based on the inclusion and exclusion criteria. The pooled prevalence of RBD in PD was 42.3 % (95 % CI 37.4-47.1 %). In subgroup analysis and meta-regression analysis, we found that the important causes of heterogeneity were the diagnosis criteria of RBD and age of PD patients (P = 0.016, P = 0.019, respectively). The results indicate that nearly half of the PD patients are suffering from RBD. Older age and longer duration are risk factors for RBD in PD. We can use the minimal diagnosis criteria for RBD according to the International Classification of Sleep Disorders to diagnose RBD patients in our daily work if polysomnography is not necessary.

Authors+Show Affiliations

Department of Neurology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu road, Qingdao, 266003, Shandong, People's Republic of China.Department of Neurology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu road, Qingdao, 266003, Shandong, People's Republic of China.Department of Neurology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu road, Qingdao, 266003, Shandong, People's Republic of China.Department of Neurology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu road, Qingdao, 266003, Shandong, People's Republic of China. tangliou@sina.com.Department of Neurology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu road, Qingdao, 266003, Shandong, People's Republic of China. xieanmu@163.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

27770275

Citation

Zhang, Xiaona, et al. "Prevalence of Rapid Eye Movement Sleep Behavior Disorder (RBD) in Parkinson's Disease: a Meta and Meta-regression Analysis." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 38, no. 1, 2017, pp. 163-170.
Zhang X, Sun X, Wang J, et al. Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson's disease: a meta and meta-regression analysis. Neurol Sci. 2017;38(1):163-170.
Zhang, X., Sun, X., Wang, J., Tang, L., & Xie, A. (2017). Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson's disease: a meta and meta-regression analysis. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 38(1), 163-170. https://doi.org/10.1007/s10072-016-2744-1
Zhang X, et al. Prevalence of Rapid Eye Movement Sleep Behavior Disorder (RBD) in Parkinson's Disease: a Meta and Meta-regression Analysis. Neurol Sci. 2017;38(1):163-170. PubMed PMID: 27770275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson's disease: a meta and meta-regression analysis. AU - Zhang,Xiaona, AU - Sun,Xiaoxuan, AU - Wang,Junhong, AU - Tang,Liou, AU - Xie,Anmu, Y1 - 2016/10/21/ PY - 2016/07/18/received PY - 2016/10/17/accepted PY - 2016/10/23/pubmed PY - 2017/2/15/medline PY - 2016/10/23/entrez KW - Meta-analysis KW - Parkinson’s disease KW - Prevalence KW - Rapid eye movement sleep behavior disorder SP - 163 EP - 170 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 38 IS - 1 N2 - Rapid eye movement sleep behavior disorder (RBD) is thought to be one of the most frequent preceding symptoms of Parkinson's disease (PD). However, the prevalence of RBD in PD stated in the published studies is still inconsistent. We conducted a meta and meta-regression analysis in this paper to estimate the pooled prevalence. We searched the electronic databases of PubMed, ScienceDirect, EMBASE and EBSCO up to June 2016 for related articles. STATA 12.0 statistics software was used to calculate the available data from each research. The prevalence of RBD in PD patients in each study was combined to a pooled prevalence with a 95 % confidence interval (CI). Subgroup analysis and meta-regression analysis were performed to search for the causes of the heterogeneity. A total of 28 studies with 6869 PD cases were deemed eligible and included in our meta-analysis based on the inclusion and exclusion criteria. The pooled prevalence of RBD in PD was 42.3 % (95 % CI 37.4-47.1 %). In subgroup analysis and meta-regression analysis, we found that the important causes of heterogeneity were the diagnosis criteria of RBD and age of PD patients (P = 0.016, P = 0.019, respectively). The results indicate that nearly half of the PD patients are suffering from RBD. Older age and longer duration are risk factors for RBD in PD. We can use the minimal diagnosis criteria for RBD according to the International Classification of Sleep Disorders to diagnose RBD patients in our daily work if polysomnography is not necessary. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/27770275/Prevalence_of_rapid_eye_movement_sleep_behavior_disorder__RBD__in_Parkinson's_disease:_a_meta_and_meta_regression_analysis_ L2 - https://link.springer.com/10.1007/s10072-016-2744-1 DB - PRIME DP - Unbound Medicine ER -