Tags

Type your tag names separated by a space and hit enter

The emergent role of exosomes in glioma.
J Clin Neurosci 2017; 35:13-23JC

Abstract

Extracellular vesicles (EVs) are known mediators of intercellular communication for both normal and tumour cells. With the capability to transfer nucleic acids, proteins and lipids, EVs are able to influence numerous functional and pathological aspects of both donor and recipient cells. The tumour microenvironment possesses a high level of complex heterogeneity, particularly within the most prominent brain malignancy, glioblastoma multiforme (GBM). This complexity relies on a network-based communication between many different components of the local niche, including the various cell types, stroma, blood vessels, secreted factors and surrounding matrix. Exosomes are one type of EV which facilitates this intercellular communication and cross-talk within the tumour microenvironment. Exosomes secreted by tumour cells are increasingly recognized in a number of processes underlying tumour progression including facilitating the transport of receptors, signalling molecules, oncogenic genes and miRNA. They are emerging as a key component in the biogenesis of glioma, in addition to contributing to the modification of the surrounding microenvironment to support tumour progression. In this review we describe advancements in the understanding of the biology of exosomes, as well as their roles in tumour progression, as a tumour biomarker for tracking cancer progression, and as a potential therapeutic target/delivery system, with a contextual emphasis on GBM.

Authors+Show Affiliations

Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia.Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia; Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia.Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia.Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia.Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia; Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia.Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia; Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia. Electronic address: stanley.stylli@mh.org.au.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27771233

Citation

Gourlay, J, et al. "The Emergent Role of Exosomes in Glioma." Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, vol. 35, 2017, pp. 13-23.
Gourlay J, Morokoff AP, Luwor RB, et al. The emergent role of exosomes in glioma. J Clin Neurosci. 2017;35:13-23.
Gourlay, J., Morokoff, A. P., Luwor, R. B., Zhu, H. J., Kaye, A. H., & Stylli, S. S. (2017). The emergent role of exosomes in glioma. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 35, pp. 13-23. doi:10.1016/j.jocn.2016.09.021.
Gourlay J, et al. The Emergent Role of Exosomes in Glioma. J Clin Neurosci. 2017;35:13-23. PubMed PMID: 27771233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The emergent role of exosomes in glioma. AU - Gourlay,J, AU - Morokoff,A P, AU - Luwor,R B, AU - Zhu,H-J, AU - Kaye,A H, AU - Stylli,S S, Y1 - 2016/10/19/ PY - 2016/07/14/received PY - 2016/09/26/accepted PY - 2016/10/25/pubmed PY - 2017/2/2/medline PY - 2016/10/25/entrez KW - Exosomes KW - Extracellular vesicles KW - Glioblastoma multiforme KW - Glioma SP - 13 EP - 23 JF - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JO - J Clin Neurosci VL - 35 N2 - Extracellular vesicles (EVs) are known mediators of intercellular communication for both normal and tumour cells. With the capability to transfer nucleic acids, proteins and lipids, EVs are able to influence numerous functional and pathological aspects of both donor and recipient cells. The tumour microenvironment possesses a high level of complex heterogeneity, particularly within the most prominent brain malignancy, glioblastoma multiforme (GBM). This complexity relies on a network-based communication between many different components of the local niche, including the various cell types, stroma, blood vessels, secreted factors and surrounding matrix. Exosomes are one type of EV which facilitates this intercellular communication and cross-talk within the tumour microenvironment. Exosomes secreted by tumour cells are increasingly recognized in a number of processes underlying tumour progression including facilitating the transport of receptors, signalling molecules, oncogenic genes and miRNA. They are emerging as a key component in the biogenesis of glioma, in addition to contributing to the modification of the surrounding microenvironment to support tumour progression. In this review we describe advancements in the understanding of the biology of exosomes, as well as their roles in tumour progression, as a tumour biomarker for tracking cancer progression, and as a potential therapeutic target/delivery system, with a contextual emphasis on GBM. SN - 1532-2653 UR - https://www.unboundmedicine.com/medline/citation/27771233/The_emergent_role_of_exosomes_in_glioma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(16)30445-3 DB - PRIME DP - Unbound Medicine ER -