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The association between vitamin D receptor polymorphisms and serum 25-hydroxyvitamin D levels with ulcerative colitis in Chinese Han population.
Clin Res Hepatol Gastroenterol. 2017 Feb; 41(1):110-117.CR

Abstract

There is now growing evidence suggesting that Vitamin D is playing a critical role in modulating the innate and adaptive immune responses. Several polymorphisms have been identified in the vitamin D receptor (VDR) gene but their association with ulcerative colitis (UC) susceptibility remained controversy. In the current study, we examined the association between VDR polymorphisms and serum level of 25-hydroxyvitamin D [25(OH)D] with UC in Chinese Han population. Polymorphisms of FokI (rs2228570)/BsmI (rs1544410)/ApaI (rs7975232)/TaqI (rs731236) in the VDR gene were assessed in a case-control study comprising 404 UC patients and 612 controls. Moreover, 25(OH)D levels were measured by electro-chemiluminescence immunoassay in 75 UC patients and 120 controls. Our results suggested that BsmI polymorphism frequency was significantly lower in UC patients (P=0.028), and the frequency of AAC haplotype formed by BsmI, ApaI and TaqI was also significantly lower in UC patients (P=0.012). Moreover, FokI polymorphism was more frequently observed in patients with mild and moderate UC as compared to those with severe UC (P=0.001, P<0.001, respectively). Average 25(OH)D level was lower in UC patients than in controls (19.3±6.8 vs. 21.8±7.3ng/mL, P=0.017), and was significantly correlated with hemoglobin (β=0.49, P<0.001), C-reactive protein (β=-0.36, P<0.001), severity of UC (β=-0.21, P=0.025) and FokI polymorphism (β=-0.20, P=0.031) in UC patients. Interestingly, there was a significant correlation between FokI polymorphism and vitamin D deficiency (<20ng/mL) in UC patients (P=0.006). Together, these results supported that VDR polymorphisms and 25(OH)D level were significantly correlated with UC risk and severity in Chinese Han population.

Authors+Show Affiliations

Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.Department of Gastroenterology, the Wenzhou Central Hospital, Wenzhou, China.Department of Gastroenterology, the Wenzhou Central Hospital, Wenzhou, China.Department of Gastroenterology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.Department of Gastroenterology, Wenzhou Renmin Hospital, Wenzhou, China.Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address: wzjiangyi@yeah.net.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27771345

Citation

Zheng, Shu-Zi, et al. "The Association Between Vitamin D Receptor Polymorphisms and Serum 25-hydroxyvitamin D Levels With Ulcerative Colitis in Chinese Han Population." Clinics and Research in Hepatology and Gastroenterology, vol. 41, no. 1, 2017, pp. 110-117.
Zheng SZ, Zhang DG, Wu H, et al. The association between vitamin D receptor polymorphisms and serum 25-hydroxyvitamin D levels with ulcerative colitis in Chinese Han population. Clin Res Hepatol Gastroenterol. 2017;41(1):110-117.
Zheng, S. Z., Zhang, D. G., Wu, H., Jiang, L. J., Jin, J., Lin, X. Q., Ding, R., & Jiang, Y. (2017). The association between vitamin D receptor polymorphisms and serum 25-hydroxyvitamin D levels with ulcerative colitis in Chinese Han population. Clinics and Research in Hepatology and Gastroenterology, 41(1), 110-117. https://doi.org/10.1016/j.clinre.2016.09.001
Zheng SZ, et al. The Association Between Vitamin D Receptor Polymorphisms and Serum 25-hydroxyvitamin D Levels With Ulcerative Colitis in Chinese Han Population. Clin Res Hepatol Gastroenterol. 2017;41(1):110-117. PubMed PMID: 27771345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between vitamin D receptor polymorphisms and serum 25-hydroxyvitamin D levels with ulcerative colitis in Chinese Han population. AU - Zheng,Shu-Zi, AU - Zhang,Da-Guan, AU - Wu,Hao, AU - Jiang,Li-Jia, AU - Jin,Jie, AU - Lin,Xiu-Qing, AU - Ding,Ran, AU - Jiang,Yi, Y1 - 2016/10/19/ PY - 2016/04/28/received PY - 2016/08/18/revised PY - 2016/09/02/accepted PY - 2016/10/25/pubmed PY - 2018/3/6/medline PY - 2016/10/25/entrez SP - 110 EP - 117 JF - Clinics and research in hepatology and gastroenterology JO - Clin Res Hepatol Gastroenterol VL - 41 IS - 1 N2 - There is now growing evidence suggesting that Vitamin D is playing a critical role in modulating the innate and adaptive immune responses. Several polymorphisms have been identified in the vitamin D receptor (VDR) gene but their association with ulcerative colitis (UC) susceptibility remained controversy. In the current study, we examined the association between VDR polymorphisms and serum level of 25-hydroxyvitamin D [25(OH)D] with UC in Chinese Han population. Polymorphisms of FokI (rs2228570)/BsmI (rs1544410)/ApaI (rs7975232)/TaqI (rs731236) in the VDR gene were assessed in a case-control study comprising 404 UC patients and 612 controls. Moreover, 25(OH)D levels were measured by electro-chemiluminescence immunoassay in 75 UC patients and 120 controls. Our results suggested that BsmI polymorphism frequency was significantly lower in UC patients (P=0.028), and the frequency of AAC haplotype formed by BsmI, ApaI and TaqI was also significantly lower in UC patients (P=0.012). Moreover, FokI polymorphism was more frequently observed in patients with mild and moderate UC as compared to those with severe UC (P=0.001, P<0.001, respectively). Average 25(OH)D level was lower in UC patients than in controls (19.3±6.8 vs. 21.8±7.3ng/mL, P=0.017), and was significantly correlated with hemoglobin (β=0.49, P<0.001), C-reactive protein (β=-0.36, P<0.001), severity of UC (β=-0.21, P=0.025) and FokI polymorphism (β=-0.20, P=0.031) in UC patients. Interestingly, there was a significant correlation between FokI polymorphism and vitamin D deficiency (<20ng/mL) in UC patients (P=0.006). Together, these results supported that VDR polymorphisms and 25(OH)D level were significantly correlated with UC risk and severity in Chinese Han population. SN - 2210-741X UR - https://www.unboundmedicine.com/medline/citation/27771345/The_association_between_vitamin_D_receptor_polymorphisms_and_serum_25_hydroxyvitamin_D_levels_with_ulcerative_colitis_in_Chinese_Han_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2210-7401(16)30131-0 DB - PRIME DP - Unbound Medicine ER -