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The interaction between physical activity and obesity gene variants in association with BMI: Does the obesogenic environment matter?
Health Place 2016; 42:159-165HP

Abstract

Little is known about how obesity susceptibility single nucleotide polymorphisms (SNPs) interact with moderate to vigorous physical activity (MVPA) in relation to BMI during adolescence, once obesogenic neighborhood factors are accounted for. In race stratified models, including European (EA; N=4977), African (AA; N=1726), and Hispanic Americans (HA; N=1270) from the National Longitudinal Study of Adolescent to Adult Health (1996; ages 12-21), we assessed the evidence for a SNPxMVPA interaction with BMI-for-age Z score, once accounting for obesogenic neighborhood factors including physical activity amenities, transportation and recreation infrastructure, poverty and crime. Eight SNPxMVPA interactions with suggestive significance (p<0.10; three in each EA, and AA, two in HA) were observed showing attenuation on BMI-for-age Z score in adolescents with ≥5 versus <5 bouts/week MVPA, except for rs10146997 (near NRXN3). Findings were robust to the inclusion of neighborhood-level variables as covariates. These findings suggest that any attenuation from MVPA on a genetic susceptibility to obesity during adolescence is likely not operating through obesogenic neighborhood factors.

Authors+Show Affiliations

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514 USA. Electronic address: migraff@email.unc.edu.RAND Corporation, Santa Monica, CA 90401 USA.Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514 USA; Carolina Population Center, University of North Carolina, Chapel Hill, NC 27514 USA.Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514 USA.Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514 USA.Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514 USA; Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27514 USA.Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27514 USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27514 USA.Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27514 USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27514 USA.Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27514 USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27514 USA.Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514 USA; Department of Sociology, Univlersity of North Carolina, Chapel Hill, NC 27514 USA.Carolina Population Center, University of North Carolina, Chapel Hill, NC 27514 USA; Department of Nutrition Gillings School of Global Public Health & School of Medicine, University of North Carolina, Chapel Hill, NC 27514 USA.

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

27771443

Citation

Graff, M, et al. "The Interaction Between Physical Activity and Obesity Gene Variants in Association With BMI: Does the Obesogenic Environment Matter?" Health & Place, vol. 42, 2016, pp. 159-165.
Graff M, Richardson AS, Young KL, et al. The interaction between physical activity and obesity gene variants in association with BMI: Does the obesogenic environment matter? Health Place. 2016;42:159-165.
Graff, M., Richardson, A. S., Young, K. L., Mazul, A. L., Highland, H., North, K. E., ... Gordon-Larsen, P. (2016). The interaction between physical activity and obesity gene variants in association with BMI: Does the obesogenic environment matter? Health & Place, 42, pp. 159-165. doi:10.1016/j.healthplace.2016.09.003.
Graff M, et al. The Interaction Between Physical Activity and Obesity Gene Variants in Association With BMI: Does the Obesogenic Environment Matter. Health Place. 2016;42:159-165. PubMed PMID: 27771443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The interaction between physical activity and obesity gene variants in association with BMI: Does the obesogenic environment matter? AU - Graff,M, AU - Richardson,A S, AU - Young,K L, AU - Mazul,A L, AU - Highland,Heather, AU - North,K E, AU - Mohlke,K L, AU - Lange,L A, AU - Lange,E M, AU - Harris,K M, AU - Gordon-Larsen,P, Y1 - 2016/10/20/ PY - 2015/11/10/received PY - 2016/09/23/revised PY - 2016/09/26/accepted PY - 2016/10/25/pubmed PY - 2018/4/26/medline PY - 2016/10/25/entrez KW - Adolescence KW - African and Hispanic American KW - BMI KW - Genetics of obesity KW - Physical activity SP - 159 EP - 165 JF - Health & place JO - Health Place VL - 42 N2 - Little is known about how obesity susceptibility single nucleotide polymorphisms (SNPs) interact with moderate to vigorous physical activity (MVPA) in relation to BMI during adolescence, once obesogenic neighborhood factors are accounted for. In race stratified models, including European (EA; N=4977), African (AA; N=1726), and Hispanic Americans (HA; N=1270) from the National Longitudinal Study of Adolescent to Adult Health (1996; ages 12-21), we assessed the evidence for a SNPxMVPA interaction with BMI-for-age Z score, once accounting for obesogenic neighborhood factors including physical activity amenities, transportation and recreation infrastructure, poverty and crime. Eight SNPxMVPA interactions with suggestive significance (p<0.10; three in each EA, and AA, two in HA) were observed showing attenuation on BMI-for-age Z score in adolescents with ≥5 versus <5 bouts/week MVPA, except for rs10146997 (near NRXN3). Findings were robust to the inclusion of neighborhood-level variables as covariates. These findings suggest that any attenuation from MVPA on a genetic susceptibility to obesity during adolescence is likely not operating through obesogenic neighborhood factors. SN - 1873-2054 UR - https://www.unboundmedicine.com/medline/citation/27771443/The_interaction_between_physical_activity_and_obesity_gene_variants_in_association_with_BMI:_Does_the_obesogenic_environment_matter L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8292(16)30269-6 DB - PRIME DP - Unbound Medicine ER -