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Substitution of meat and fish with vegetables or potatoes and risk of myocardial infarction.
Br J Nutr. 2016 Nov; 116(9):1602-1610.BJ

Abstract

Red meat has been suggested to be adversely associated with risk of myocardial infarction (MI), whereas vegetable consumption has been found to be protective. The aim of this study was to investigate substitutions of red meat, poultry and fish with vegetables or potatoes for MI prevention. We followed up 29 142 women and 26 029 men in the Danish Diet, Cancer and Health study aged 50-64 years with no known history of MI at baseline. Diet was assessed by a validated 192-item FFQ at baseline. Adjusted Cox proportional hazard models were used to calculate hazard ratios (HR) and 95 % CI for MI associated with specified food substitutions of 150 g/week. During a median follow-up of 13·6 years, we identified 656 female and 1694 male cases. Among women, the HR for MI when replacing red meat with vegetables was 0·94 (95 % CI 0·90, 0·98). Replacing fatty fish with vegetables was associated with a higher risk of MI (HR 1·23; 95 % CI 1·05, 1·45), whereas an inverse, statistically non-significant association was found for lean fish (HR 0·93; 95 % CI 0·83, 1·05). Substituting poultry with vegetables was not associated with risk of MI (HR 1·00; 95 % CI 0·90, 1·11). Findings for substitution with potatoes were similar to findings for vegetables. Among men, a similar pattern was observed, but the associations were weak and mostly statistically non-significant. This study suggests that replacing red meat with vegetables or potatoes is associated with a lower risk of MI, whereas replacing fatty fish with vegetables or potatoes is associated with a higher risk of MI.

Authors+Show Affiliations

1Section for Epidemiology,Department of Public Health,Aarhus University,DK-8000 Aarhus C,Denmark.1Section for Epidemiology,Department of Public Health,Aarhus University,DK-8000 Aarhus C,Denmark.2Danish Cancer Society Research Center,DK-2100 Copenhagen Ø,Denmark.3Department of Medicine,Channing Division of Network Medicine,Brigham and Women's Hospital,Harvard Medical School,Boston,MA 02115,USA.5Department of Cardiology,Center for Cardiovascular Research,Aalborg University Hospital,DK-9000 Aalborg,Denmark.1Section for Epidemiology,Department of Public Health,Aarhus University,DK-8000 Aarhus C,Denmark.1Section for Epidemiology,Department of Public Health,Aarhus University,DK-8000 Aarhus C,Denmark.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27774916

Citation

Würtz, Anne M L., et al. "Substitution of Meat and Fish With Vegetables or Potatoes and Risk of Myocardial Infarction." The British Journal of Nutrition, vol. 116, no. 9, 2016, pp. 1602-1610.
Würtz AM, Hansen MD, Tjønneland A, et al. Substitution of meat and fish with vegetables or potatoes and risk of myocardial infarction. Br J Nutr. 2016;116(9):1602-1610.
Würtz, A. M., Hansen, M. D., Tjønneland, A., Rimm, E. B., Schmidt, E. B., Overvad, K., & Jakobsen, M. U. (2016). Substitution of meat and fish with vegetables or potatoes and risk of myocardial infarction. The British Journal of Nutrition, 116(9), 1602-1610.
Würtz AM, et al. Substitution of Meat and Fish With Vegetables or Potatoes and Risk of Myocardial Infarction. Br J Nutr. 2016;116(9):1602-1610. PubMed PMID: 27774916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Substitution of meat and fish with vegetables or potatoes and risk of myocardial infarction. AU - Würtz,Anne M L, AU - Hansen,Mette D, AU - Tjønneland,Anne, AU - Rimm,Eric B, AU - Schmidt,Erik B, AU - Overvad,Kim, AU - Jakobsen,Marianne U, Y1 - 2016/10/24/ PY - 2016/10/25/pubmed PY - 2017/5/23/medline PY - 2016/10/25/entrez KW - HR hazard ratio KW - MI myocardial infarction KW - Cohort studies KW - Fish KW - Meat KW - Myocardial infarction KW - Potatoes KW - Substitution models KW - Vegetables SP - 1602 EP - 1610 JF - The British journal of nutrition JO - Br J Nutr VL - 116 IS - 9 N2 - Red meat has been suggested to be adversely associated with risk of myocardial infarction (MI), whereas vegetable consumption has been found to be protective. The aim of this study was to investigate substitutions of red meat, poultry and fish with vegetables or potatoes for MI prevention. We followed up 29 142 women and 26 029 men in the Danish Diet, Cancer and Health study aged 50-64 years with no known history of MI at baseline. Diet was assessed by a validated 192-item FFQ at baseline. Adjusted Cox proportional hazard models were used to calculate hazard ratios (HR) and 95 % CI for MI associated with specified food substitutions of 150 g/week. During a median follow-up of 13·6 years, we identified 656 female and 1694 male cases. Among women, the HR for MI when replacing red meat with vegetables was 0·94 (95 % CI 0·90, 0·98). Replacing fatty fish with vegetables was associated with a higher risk of MI (HR 1·23; 95 % CI 1·05, 1·45), whereas an inverse, statistically non-significant association was found for lean fish (HR 0·93; 95 % CI 0·83, 1·05). Substituting poultry with vegetables was not associated with risk of MI (HR 1·00; 95 % CI 0·90, 1·11). Findings for substitution with potatoes were similar to findings for vegetables. Among men, a similar pattern was observed, but the associations were weak and mostly statistically non-significant. This study suggests that replacing red meat with vegetables or potatoes is associated with a lower risk of MI, whereas replacing fatty fish with vegetables or potatoes is associated with a higher risk of MI. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/27774916/Substitution_of_meat_and_fish_with_vegetables_or_potatoes_and_risk_of_myocardial_infarction_ L2 - https://www.cambridge.org/core/product/identifier/S0007114516003500/type/journal_article DB - PRIME DP - Unbound Medicine ER -