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The role of hydrogen sulphide in blood pressure regulation.
Physiol Res. 2016 10 24; 65(Suppl 3):S273-S289.PR

Abstract

Cardiovascular studies have confirmed that hydrogen sulphide (H(2)S) is involved in various signaling pathways in both physiological and pathological conditions, including hypertension. In contrast to nitric oxide (NO), which has a clear vasorelaxant action, H(2)S has both vasorelaxing and vasoconstricting effects on the cardiovascular system. H(2)S is an important antihypertensive agent, and the reduced production of H(2)S and the alterations in its functions are involved in the initiation of spontaneous hypertension. Moreover, cross-talk between H(2)S and NO has been reported. NO-H(2)S interactions include reactions between the molecules themselves, and each has been shown to regulate the endogenous production of the other. In addition, NO and H(2)S can interact to form a nitrosothiol/s complex, which has original properties and represents a novel nitroso-sulphide signaling pathway. Furthermore, recent results have shown that the interaction between H(2)S and NO could be involved in the endothelium-regulated compensatory mechanisms that are observed in juvenile spontaneously hypertensive rats. The present review is devoted to role of H(2)S in vascular tone regulation. We primarily focus on the mechanisms of H(2)S-NO interactions and on the role of H(2)S in blood pressure regulation in normotensive and spontaneously hypertensive rats.

Authors+Show Affiliations

Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic. sona.cacanyiova@savba.sk.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27775417

Citation

Cacanyiova, S, et al. "The Role of Hydrogen Sulphide in Blood Pressure Regulation." Physiological Research, vol. 65, no. Suppl 3, 2016, pp. S273-S289.
Cacanyiova S, Berenyiova A, Kristek F. The role of hydrogen sulphide in blood pressure regulation. Physiol Res. 2016;65(Suppl 3):S273-S289.
Cacanyiova, S., Berenyiova, A., & Kristek, F. (2016). The role of hydrogen sulphide in blood pressure regulation. Physiological Research, 65(Suppl 3), S273-S289.
Cacanyiova S, Berenyiova A, Kristek F. The Role of Hydrogen Sulphide in Blood Pressure Regulation. Physiol Res. 2016 10 24;65(Suppl 3):S273-S289. PubMed PMID: 27775417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of hydrogen sulphide in blood pressure regulation. AU - Cacanyiova,S, AU - Berenyiova,A, AU - Kristek,F, PY - 2016/10/25/pubmed PY - 2017/3/23/medline PY - 2016/10/25/entrez SP - S273 EP - S289 JF - Physiological research JO - Physiol Res VL - 65 IS - Suppl 3 N2 - Cardiovascular studies have confirmed that hydrogen sulphide (H(2)S) is involved in various signaling pathways in both physiological and pathological conditions, including hypertension. In contrast to nitric oxide (NO), which has a clear vasorelaxant action, H(2)S has both vasorelaxing and vasoconstricting effects on the cardiovascular system. H(2)S is an important antihypertensive agent, and the reduced production of H(2)S and the alterations in its functions are involved in the initiation of spontaneous hypertension. Moreover, cross-talk between H(2)S and NO has been reported. NO-H(2)S interactions include reactions between the molecules themselves, and each has been shown to regulate the endogenous production of the other. In addition, NO and H(2)S can interact to form a nitrosothiol/s complex, which has original properties and represents a novel nitroso-sulphide signaling pathway. Furthermore, recent results have shown that the interaction between H(2)S and NO could be involved in the endothelium-regulated compensatory mechanisms that are observed in juvenile spontaneously hypertensive rats. The present review is devoted to role of H(2)S in vascular tone regulation. We primarily focus on the mechanisms of H(2)S-NO interactions and on the role of H(2)S in blood pressure regulation in normotensive and spontaneously hypertensive rats. SN - 1802-9973 UR - https://www.unboundmedicine.com/medline/citation/27775417/The_role_of_hydrogen_sulphide_in_blood_pressure_regulation_ L2 - http://www.biomed.cas.cz/physiolres/pdf/65/65_S273.pdf DB - PRIME DP - Unbound Medicine ER -