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Cardiovascular effects of gasotransmitter donors.
Physiol Res. 2016 10 24; 65(Suppl 3):S291-S307.PR

Abstract

Gasotransmitters represent a subfamily of the endogenous gaseous signaling molecules that include nitric oxide (NO), carbon monoxide (CO), and hydrogen sulphide (H(2)S). These particular gases share many common features in their production and function, but they fulfill their physiological tasks in unique ways that differ from those of classical signaling molecules found in tissues and organs. These gasotransmitters may antagonize or potentiate each other's cellular effects at the level of their production, their downstream molecular targets and their direct interactions. All three gasotransmitters induce vasodilatation, inhibit apoptosis directly or by increasing the expression of anti-apoptotic genes, and activate antioxidants while inhibiting inflammatory actions. NO and CO may concomitantly participate in vasorelaxation, anti-inflammation and angiogenesis. NO and H(2)S collaborate in the regulation of vascular tone. Finally, H(2)S may upregulate the heme oxygenase/carbon monoxide (HO/CO) pathway during hypoxic conditions. All three gasotransmitters are produced by specific enzymes in different cell types that include cardiomyocytes, endothelial cells and smooth muscle cells. As translational research on gasotransmitters has exploded over the past years, drugs that alter the production/levels of the gasotransmitters themselves or modulate their signaling pathways are now being developed. This review is focused on the cardiovascular effects of NO, CO, and H(2)S. Moreover, their donors as drug targeting the cardiovascular system are briefly described.

Authors+Show Affiliations

Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic. martina.cebova@savba.sk.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27775418

Citation

Cebová, M, et al. "Cardiovascular Effects of Gasotransmitter Donors." Physiological Research, vol. 65, no. Suppl 3, 2016, pp. S291-S307.
Cebová M, Košútová M, Pecháňová O. Cardiovascular effects of gasotransmitter donors. Physiol Res. 2016;65(Suppl 3):S291-S307.
Cebová, M., Košútová, M., & Pecháňová, O. (2016). Cardiovascular effects of gasotransmitter donors. Physiological Research, 65(Suppl 3), S291-S307.
Cebová M, Košútová M, Pecháňová O. Cardiovascular Effects of Gasotransmitter Donors. Physiol Res. 2016 10 24;65(Suppl 3):S291-S307. PubMed PMID: 27775418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular effects of gasotransmitter donors. AU - Cebová,M, AU - Košútová,M, AU - Pecháňová,O, PY - 2016/10/25/pubmed PY - 2017/3/23/medline PY - 2016/10/25/entrez SP - S291 EP - S307 JF - Physiological research JO - Physiol Res VL - 65 IS - Suppl 3 N2 - Gasotransmitters represent a subfamily of the endogenous gaseous signaling molecules that include nitric oxide (NO), carbon monoxide (CO), and hydrogen sulphide (H(2)S). These particular gases share many common features in their production and function, but they fulfill their physiological tasks in unique ways that differ from those of classical signaling molecules found in tissues and organs. These gasotransmitters may antagonize or potentiate each other's cellular effects at the level of their production, their downstream molecular targets and their direct interactions. All three gasotransmitters induce vasodilatation, inhibit apoptosis directly or by increasing the expression of anti-apoptotic genes, and activate antioxidants while inhibiting inflammatory actions. NO and CO may concomitantly participate in vasorelaxation, anti-inflammation and angiogenesis. NO and H(2)S collaborate in the regulation of vascular tone. Finally, H(2)S may upregulate the heme oxygenase/carbon monoxide (HO/CO) pathway during hypoxic conditions. All three gasotransmitters are produced by specific enzymes in different cell types that include cardiomyocytes, endothelial cells and smooth muscle cells. As translational research on gasotransmitters has exploded over the past years, drugs that alter the production/levels of the gasotransmitters themselves or modulate their signaling pathways are now being developed. This review is focused on the cardiovascular effects of NO, CO, and H(2)S. Moreover, their donors as drug targeting the cardiovascular system are briefly described. SN - 1802-9973 UR - https://www.unboundmedicine.com/medline/citation/27775418/Cardiovascular_effects_of_gasotransmitter_donors_ L2 - http://www.biomed.cas.cz/physiolres/pdf/65/65_S291.pdf DB - PRIME DP - Unbound Medicine ER -