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Statin-associated muscle symptoms: position paper from the Luso-Latin American Consortium.
Curr Med Res Opin. 2017 02; 33(2):239-251.CM

Abstract

In the last two decades, statin therapy has proved to be the most potent isolated therapy for attenuation of cardiovascular risk. Its frequent use has been seen as one of the most important elements for the reduction of cardiovascular mortality in developed countries. However, the recurrent incidence of muscle symptoms in statin users raised the possibility of causal association, leading to a disease entity known as statin associated muscle symptoms (SAMS). Mechanistic studies and clinical trials, specifically designed for the study of SAMS have allowed a deeper understanding of the natural history and accurate incidence. This set of information becomes essential to avoid an unnecessary risk of severe forms of SAMS. At the same time, this concrete understanding of SAMS prevents overdiagnosis and an inadequate suspension of one of the most powerful prevention strategies of our times. In this context, the Luso-Latin American Consortium gathered all available information on the subject and presents them in detail in this document as the basis for the identification and management of SAMS.

Authors+Show Affiliations

a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.b Sociedad Argentina de Lípidos , Cordoba , Argentina.b Sociedad Argentina de Lípidos , Cordoba , Argentina.b Sociedad Argentina de Lípidos , Cordoba , Argentina.b Sociedad Argentina de Lípidos , Cordoba , Argentina.c Sociedad Mexicana de Cardiologia , Tlalpan , Federal District , Mexico.a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.d Asociación Chilena de Nutrición Clínica , Santiago , Chile.e Soceidad Colombiana de Cardiolgia Y Cirgugia Cardiovascular , Bogota , Colombia.a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.f Sociedade Portuguesa de Aterosclerose , Lisboa , Portugal.f Sociedade Portuguesa de Aterosclerose , Lisboa , Portugal.a Sociedade Brasileira de Cardiologia , Rio de Janeiro , Brazil.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27776432

Citation

Sposito, Andrei C., et al. "Statin-associated Muscle Symptoms: Position Paper From the Luso-Latin American Consortium." Current Medical Research and Opinion, vol. 33, no. 2, 2017, pp. 239-251.
Sposito AC, Faria Neto JR, Carvalho LS, et al. Statin-associated muscle symptoms: position paper from the Luso-Latin American Consortium. Curr Med Res Opin. 2017;33(2):239-251.
Sposito, A. C., Faria Neto, J. R., Carvalho, L. S., Lorenzatti, A., Cafferata, A., Elikir, G., Esteban, E., Morales Villegas, E. C., Bodanese, L. C., Alonso, R., Ruiz, A. J., Rocha, V. Z., Faludi, A. A., Xavier, H. T., Coelho, O. R., Assad, M. H., Izar, M. C., Santos, R. D., Fonseca, F. A., ... Bertolami, M. C. (2017). Statin-associated muscle symptoms: position paper from the Luso-Latin American Consortium. Current Medical Research and Opinion, 33(2), 239-251. https://doi.org/10.1080/03007995.2016.1252740
Sposito AC, et al. Statin-associated Muscle Symptoms: Position Paper From the Luso-Latin American Consortium. Curr Med Res Opin. 2017;33(2):239-251. PubMed PMID: 27776432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statin-associated muscle symptoms: position paper from the Luso-Latin American Consortium. AU - Sposito,Andrei C, AU - Faria Neto,José Rocha, AU - Carvalho,Luiz Sergio F de, AU - Lorenzatti,Alberto, AU - Cafferata,Alberto, AU - Elikir,Gerardo, AU - Esteban,Eduardo, AU - Morales Villegas,Enrique C, AU - Bodanese,Luiz Carlos, AU - Alonso,Rodrigo, AU - Ruiz,Alvaro J, AU - Rocha,Viviane Z, AU - Faludi,André A, AU - Xavier,Hermes T, AU - Coelho,Otávio Rizzi, AU - Assad,Marcelo H V, AU - Izar,Maria C, AU - Santos,Raul D, AU - Fonseca,Francisco A H, AU - Mello E Silva,Alberto, AU - Silva,Pedro Marques da, AU - Bertolami,Marcelo C, AU - ,, Y1 - 2016/12/02/ PY - 2016/10/26/pubmed PY - 2017/9/5/medline PY - 2016/10/26/entrez KW - Intolerance KW - statin KW - statin associated muscle symptoms SP - 239 EP - 251 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 33 IS - 2 N2 - In the last two decades, statin therapy has proved to be the most potent isolated therapy for attenuation of cardiovascular risk. Its frequent use has been seen as one of the most important elements for the reduction of cardiovascular mortality in developed countries. However, the recurrent incidence of muscle symptoms in statin users raised the possibility of causal association, leading to a disease entity known as statin associated muscle symptoms (SAMS). Mechanistic studies and clinical trials, specifically designed for the study of SAMS have allowed a deeper understanding of the natural history and accurate incidence. This set of information becomes essential to avoid an unnecessary risk of severe forms of SAMS. At the same time, this concrete understanding of SAMS prevents overdiagnosis and an inadequate suspension of one of the most powerful prevention strategies of our times. In this context, the Luso-Latin American Consortium gathered all available information on the subject and presents them in detail in this document as the basis for the identification and management of SAMS. SN - 1473-4877 UR - https://www.unboundmedicine.com/medline/citation/27776432/Statin_associated_muscle_symptoms:_position_paper_from_the_Luso_Latin_American_Consortium_ L2 - http://www.tandfonline.com/doi/full/10.1080/03007995.2016.1252740 DB - PRIME DP - Unbound Medicine ER -