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Chronic kidney disease and high eGFR according to body composition phenotype in adults with normal BMI.
Nutr Metab Cardiovasc Dis 2016; 26(12):1088-1095NM

Abstract

BACKGROUND AND AIMS

Body composition contributes to the risk of chronic kidney disease (CKD) and glomerular hyperfiltration. In adults with normal body mass index (BMI), the relationships of body composition with CKD and high estimated glomerular filtration rate (eGFR) are largely unknown.

METHODS AND RESULTS

We analyzed 10,734 adults from the Korean National Health and Nutrition Examination Survey (KNHANES), whose body mass index (BMI) was within the normal range (18.5-24.9 kg/m2). Body composition was categorized into four phenotypes (normal, sarcopenia alone, obesity alone, and sarcopenic obesity) based on appendicular lean mass index (ALMI) and total body fat percentage (TBF%) measured by dual-energy X-ray absorptiometry (DXA). We examined the relationship of CKD and high eGFR (eGFR ≥ 120 ml/min per 1.73 m2) with body composition phenotypes. Sarcopenia alone (14.3%), obesity alone (16.0%), and sarcopenic obesity (10.7%) were prevalent. The association between sarcopenia alone and eGFR was J-shaped, while that between sarcopenic obesity and eGFR was U-shaped. In multivariate logistic regression analysis compared with the normal phenotype, sarcopenic obesity had an elevated odds ratio (OR) for CKD (OR: 1.59, 95% CI: 1.16-2.19). Sarcopenia alone (OR: 1.87; 95% CI: 1.41-2.47) and sarcopenic obesity (OR: 2.37, 95% CI: 1.68-3.36) had elevated OR for high eGFR.

CONCLUSION

These findings suggest that decreased muscle mass and coexistence with excess adiposity show associations with CKD and high eGFR even in adults with normal BMI. Body composition measured by DXA could provide information on the relationship of body composition with CKD and high eGFR.

Authors+Show Affiliations

Division of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.Division of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address: kyubeck.lee@samsung.com.Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27776918

Citation

Hyun, Y Y., et al. "Chronic Kidney Disease and High eGFR According to Body Composition Phenotype in Adults With Normal BMI." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 26, no. 12, 2016, pp. 1088-1095.
Hyun YY, Lee KB, Rhee EJ, et al. Chronic kidney disease and high eGFR according to body composition phenotype in adults with normal BMI. Nutr Metab Cardiovasc Dis. 2016;26(12):1088-1095.
Hyun, Y. Y., Lee, K. B., Rhee, E. J., Park, C. Y., Chang, Y., & Ryu, S. (2016). Chronic kidney disease and high eGFR according to body composition phenotype in adults with normal BMI. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 26(12), pp. 1088-1095. doi:10.1016/j.numecd.2016.09.003.
Hyun YY, et al. Chronic Kidney Disease and High eGFR According to Body Composition Phenotype in Adults With Normal BMI. Nutr Metab Cardiovasc Dis. 2016;26(12):1088-1095. PubMed PMID: 27776918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic kidney disease and high eGFR according to body composition phenotype in adults with normal BMI. AU - Hyun,Y Y, AU - Lee,K B, AU - Rhee,E J, AU - Park,C Y, AU - Chang,Y, AU - Ryu,S, Y1 - 2016/09/17/ PY - 2016/03/30/received PY - 2016/07/20/revised PY - 2016/09/04/accepted PY - 2016/10/26/pubmed PY - 2017/8/2/medline PY - 2016/10/26/entrez KW - Body composition KW - Chronic kidney disease KW - Glomerular filtration rate KW - Obesity KW - Sarcopenia SP - 1088 EP - 1095 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 26 IS - 12 N2 - BACKGROUND AND AIMS: Body composition contributes to the risk of chronic kidney disease (CKD) and glomerular hyperfiltration. In adults with normal body mass index (BMI), the relationships of body composition with CKD and high estimated glomerular filtration rate (eGFR) are largely unknown. METHODS AND RESULTS: We analyzed 10,734 adults from the Korean National Health and Nutrition Examination Survey (KNHANES), whose body mass index (BMI) was within the normal range (18.5-24.9 kg/m2). Body composition was categorized into four phenotypes (normal, sarcopenia alone, obesity alone, and sarcopenic obesity) based on appendicular lean mass index (ALMI) and total body fat percentage (TBF%) measured by dual-energy X-ray absorptiometry (DXA). We examined the relationship of CKD and high eGFR (eGFR ≥ 120 ml/min per 1.73 m2) with body composition phenotypes. Sarcopenia alone (14.3%), obesity alone (16.0%), and sarcopenic obesity (10.7%) were prevalent. The association between sarcopenia alone and eGFR was J-shaped, while that between sarcopenic obesity and eGFR was U-shaped. In multivariate logistic regression analysis compared with the normal phenotype, sarcopenic obesity had an elevated odds ratio (OR) for CKD (OR: 1.59, 95% CI: 1.16-2.19). Sarcopenia alone (OR: 1.87; 95% CI: 1.41-2.47) and sarcopenic obesity (OR: 2.37, 95% CI: 1.68-3.36) had elevated OR for high eGFR. CONCLUSION: These findings suggest that decreased muscle mass and coexistence with excess adiposity show associations with CKD and high eGFR even in adults with normal BMI. Body composition measured by DXA could provide information on the relationship of body composition with CKD and high eGFR. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/27776918/Chronic_kidney_disease_and_high_eGFR_according_to_body_composition_phenotype_in_adults_with_normal_BMI_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(16)30158-2 DB - PRIME DP - Unbound Medicine ER -